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Synthesis and characterization of a metal complex containing naringin and Cu, and its antioxidant, antimicrobial, antiinflammatory and tumor cell cytotoxicity

Pereira, Regina M S ; Andrades, Norma E D ; Paulino, Niraldo ; Sawaya, Alexandra C H F ; Eberlin, Marcos N ; Marcucci, Maria C ; Favero, Giovani Marino ; Novak, Estela Maria ; Bydlowski, Sérgio Paulo

Molecules (Basel, Switzerland), 2007-07, Vol.12 (7), p.1352-1366 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Synthesis and characterization of a metal complex containing naringin and Cu, and its antioxidant, antimicrobial, antiinflammatory and tumor cell cytotoxicity
Autor: Pereira, Regina M S ; Andrades, Norma E D ; Paulino, Niraldo ; Sawaya, Alexandra C H F ; Eberlin, Marcos N ; Marcucci, Maria C ; Favero, Giovani Marino ; Novak, Estela Maria ; Bydlowski, Sérgio Paulo
Assuntos: Animals ; Anti-Bacterial Agents - pharmacology ; anti-inflammatory ; Anti-Inflammatory Agents - pharmacology ; antimicrobial and antioxidant activities ; Antioxidants - pharmacology ; Biphenyl Compounds - chemistry ; Cell Cycle - drug effects ; Cell Death - drug effects ; Copper - chemistry ; Drug Screening Assays, Antitumor ; Flavanones - administration & dosage ; Flavanones - chemical synthesis ; Flavanones - chemistry ; Flavanones - pharmacology ; flavonoid ; Free Radical Scavengers - chemistry ; Humans ; Hydrazines - chemistry ; Hydrogen-Ion Concentration ; K562 Cells ; Magnetic Resonance Spectroscopy ; Male ; Mice ; Microbial Sensitivity Tests ; Naringin complexes ; Picrates ; Spectrometry, Mass, Electrospray Ionization ; Spectrophotometry, Ultraviolet
É parte de: Molecules (Basel, Switzerland), 2007-07, Vol.12 (7), p.1352-1366
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: The antioxidant activity of flavonoids is believed to increase when they are coordinated with transition metal ions. However, the literature on this subject is contradictory and the outcome seems to largely depend on the experimental conditions. In order to understand the contribution of the metal coordination and the type of interaction between a flavonoid and the metal ion, in this study a new metal complex of Cu (II) with naringin was synthesized and characterized by FT-IR, UV-VIS, mass spectrometry (ESI-MS/MS), elemental analysis and 1H-NMR. The results of these analyses indicate that the complex has a Cu (II) ion coordinated via positions 4 and 5 of the flavonoid. The antioxidant, anti-inflammatory and antimicrobial activities of this complex were studied and compared with the activity of free naringin. The Naringin-Cu (II) complex 1 showed higher antioxidant, anti-inflammatory and tumor cell cytotoxicity activities than free naringin without reducing cell viability.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Synthesis and characterization of a metal complex containing naringin and Cu, and its antioxidant, antimicrobial, antiinflammatory and tumor cell cytotoxicity

Pereira, Regina M S ; Andrades, Norma E D ; Paulino, Niraldo ; Sawaya, Alexandra C H F ; Eberlin, Marcos N ; Marcucci, Maria C ; Favero, Giovani Marino ; Novak, Estela Maria ; Bydlowski, Sérgio Paulo

Switzerland: MDPI AG

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