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Single-Dose Pharmacokinetics of Atrasentan, an Endothelin-A Receptor Antagonist

Samara, Emil ; Dutta, Sandeep ; Cao, Guoliang ; Granneman, G. R. ; Dordal, Margaret S. ; MD, R. J. Padley

Journal of clinical pharmacology, 2001-04, Vol.41 (4), p.397-403 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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Título:
Single-Dose Pharmacokinetics of Atrasentan, an Endothelin-A Receptor Antagonist
Autor: Samara, Emil ; Dutta, Sandeep ; Cao, Guoliang ; Granneman, G. R. ; Dordal, Margaret S. ; MD, R. J. Padley
Assuntos: Administration, Oral ; Adolescent ; Adult ; Analysis of Variance ; Biological and medical sciences ; Blood Pressure - drug effects ; Cardiovascular system ; Dose-Response Relationship, Drug ; Double-Blind Method ; Endothelin Receptor Antagonists ; Endothelin-1 - drug effects ; Half-Life ; Humans ; Male ; Medical sciences ; Metabolic Clearance Rate ; Middle Aged ; Miscellaneous ; Pharmacology. Drug treatments ; Placebos
É parte de: Journal of clinical pharmacology, 2001-04, Vol.41 (4), p.397-403
Notas: istex:0457AFBDE3F461EA7F593343C3E509002739A1D0
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ArticleID:JCPH428
ObjectType-Article-2
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ObjectType-News-3
content type line 23
Descrição: The pharmacokinetics of 1, 10, 23.25, and 139.5 mg doses of atrasentan was assessed in a placebo‐controlled, double‐blind, single oral dose study in 24 healthy male subjects. Atrasentan was well tolerated. Atrasentan pharmacokinetics was linear in the 1 to 23.25 mg dose range, with some dose dependency in the highest dose group. Harmonic mean terminal half‐life was similar across all dose groups (20–25 h). Apparent oral clearance was low (12 L/h) for the highest dose group compared with the other three dose groups (21–27 L/h). The apparent volume of distribution was large (∼6 L/kg), consistent with extensive tissue distribution.
Editor: Oxford, UK: Blackwell Publishing Ltd
Idioma: Inglês

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Single-Dose Pharmacokinetics of Atrasentan, an Endothelin-A Receptor Antagonist

Samara, Emil ; Dutta, Sandeep ; Cao, Guoliang ; Granneman, G. R. ; Dordal, Margaret S. ; MD, R. J. Padley

Oxford, UK: Blackwell Publishing Ltd

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