Idioma:

Ketamine Exhibits Different Neuroanatomical Profile After Mammalian Target of Rapamycin Inhibition in the Prefrontal Cortex: the Role of Inflammation and Oxidative Stress

Abelaira, Helena M. ; Réus, Gislaine Z. ; Ignácio, Zuleide M. ; dos Santos, Maria Augusta B. ; de Moura, Airam B. ; Matos, Danyela ; Demo, Júlia P. ; da Silva, Júlia B. I. ; Danielski, Lucineia G. ; Petronilho, Fabricia ; Carvalho, André F. ; Quevedo, João

Molecular neurobiology, 2017-09, Vol.54 (7), p.5335-5346 [Periódico revisado por pares]

New York: Springer US

Texto completo disponível

Citações Citado por

Enviar para

Título:
Ketamine Exhibits Different Neuroanatomical Profile After Mammalian Target of Rapamycin Inhibition in the Prefrontal Cortex: the Role of Inflammation and Oxidative Stress
Autor: Abelaira, Helena M. ; Réus, Gislaine Z. ; Ignácio, Zuleide M. ; dos Santos, Maria Augusta B. ; de Moura, Airam B. ; Matos, Danyela ; Demo, Júlia P. ; da Silva, Júlia B. I. ; Danielski, Lucineia G. ; Petronilho, Fabricia ; Carvalho, André F. ; Quevedo, João
Assuntos: Activation ; Activation analysis ; Amygdala ; Amygdala - metabolism ; Anatomy ; Anatomy & physiology ; Animals ; Antidepressants ; Antidepressive Agents - pharmacology ; Antioxidants - pharmacology ; Bioindicators ; Biomedical and Life Sciences ; Biomedicine ; Brain ; Brain architecture ; Catalase ; Cell Biology ; Damage ; Depression ; Encephalitis - prevention & control ; Enzymes ; Glutamic acid receptors ; Glutamic acid receptors (ionotropic) ; Hippocampus ; Inflammation ; Inhibition ; Ketamine ; Ketamine - pharmacology ; Male ; Mammals ; Markers ; Mental depression ; N-Methyl-D-aspartic acid receptors ; Neurobiology ; Neurology ; Neurosciences ; Nitrates ; Nitrites ; Nuclei ; Nucleus accumbens ; Oxidative stress ; Oxidative Stress - drug effects ; Peroxidase ; Prefrontal cortex ; Prefrontal Cortex - drug effects ; Prefrontal Cortex - metabolism ; Rapamycin ; Rats ; Rats, Wistar ; Rodents ; Signal transduction ; Signal Transduction - drug effects ; Sirolimus - pharmacology ; Stress ; Superoxide ; Superoxide dismutase ; Swimming ; TOR protein
É parte de: Molecular neurobiology, 2017-09, Vol.54 (7), p.5335-5346
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Studies indicated that mammalian target of rapamycin (mTOR), oxidative stress, and inflammation are involved in the pathophysiology of major depressive disorder (MDD). Ketamine, an N -methyl- d -aspartate (NMDA) receptor antagonist, has been identified as a novel MDD therapy; however, the antidepressant mechanism is not fully understood. In addition, the effects of ketamine after mTOR inhibition have not been fully investigated. In the present study, we examined the behavioral and biochemical effects of ketamine in the prefrontal cortex (PFC), hippocampus, amygdala, and nucleus accumbens after inhibition of mTOR signaling in the PFC. Male adult Wistar rats received pharmacological mTOR inhibitor, rapamycin (0.2 nmol) or vehicle into the PFC and then a single dose of ketamine (15 mg/kg, i.p.). Immobility was assessed in forced swimming tests, and then oxidative stress parameters and inflammatory markers were evaluated in the brain and periphery. mTOR activation in the PFC was essential to ketamine’s antidepressant-like effects. Ketamine increased lipid damage in the PFC, hippocampus, and amygdala. Protein carbonyl was elevated in the PFC, amygdala, and NAc after ketamine administration. Ketamine also increased nitrite/nitrate in the PFC, hippocampus, amygdala, and NAc. Myeloperoxidase activity increased in the hippocampus and NAc after ketamine administration. The activities of superoxide dismutase and catalase were reduced after ketamine administration in all brain areas studied. Inhibition of mTOR signaling pathways by rapamycin in the PFC was required to protect against oxidative stress by reducing damage and increasing antioxidant enzymes. Finally, the TNF-α level was increased in serum by ketamine; however, the rapamycin plus treatment group was not able to block this increase. Activation of mTOR in the PFC is involved in the antidepressant-like effects of ketamine; however, the inhibition of this pathway was able to protect certain brain areas against oxidative stress, without affecting inflammation parameters.
Editor: New York: Springer US
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Ketamine Exhibits Different Neuroanatomical Profile After Mammalian Target of Rapamycin Inhibition in the Prefrontal Cortex: the Role of Inflammation and Oxidative Stress

Abelaira, Helena M. ; Réus, Gislaine Z. ; Ignácio, Zuleide M. ; dos Santos, Maria Augusta B. ; de Moura, Airam B. ; Matos, Danyela ; Demo, Júlia P. ; da Silva, Júlia B. I. ; Danielski, Lucineia G. ; Petronilho, Fabricia ; Carvalho, André F. ; Quevedo, João

New York: Springer US

Buscando em bases de dados remotas. Favor aguardar.