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The architecture of respiratory supercomplexes

Letts, James A ; Fiedorczuk, Karol ; Sazanov, Leonid A

Nature (London), 2016-09, Vol.537 (7622), p.644-648 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
The architecture of respiratory supercomplexes
Autor: Letts, James A ; Fiedorczuk, Karol ; Sazanov, Leonid A
Assuntos: Animals ; Binding Sites ; Catalytic Domain ; Cell research ; Cell Respiration ; Cellular biology ; Cryoelectron Microscopy ; Cytochrome ; Cytological research ; Electron Transport ; Electron Transport Complex I - chemistry ; Electron Transport Complex I - ultrastructure ; Electron Transport Complex III - chemistry ; Electron Transport Complex III - ultrastructure ; Electron Transport Complex IV - chemistry ; Electron Transport Complex IV - ultrastructure ; Heart ; Membranes ; Microscopy ; Mitochondria ; Mitochondria - enzymology ; Mitochondria - metabolism ; Models, Molecular ; Oxidation ; Protein Binding ; Protein Conformation ; Protein Stability ; Protein Structure, Secondary ; Protein Subunits - chemistry ; Protein Subunits - metabolism ; Proteins ; Reactive Oxygen Species - metabolism ; Sheep
É parte de: Nature (London), 2016-09, Vol.537 (7622), p.644-648
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Mitochondrial electron transport chain complexes are organized into supercomplexes responsible for carrying out cellular respiration. Here we present three architectures of mammalian (ovine) supercomplexes determined by cryo-electron microscopy. We identify two distinct arrangements of supercomplex CICIII CIV (the respirasome)-a major 'tight' form and a minor 'loose' form (resolved at the resolution of 5.8 Å and 6.7 Å, respectively), which may represent different stages in supercomplex assembly or disassembly. We have also determined an architecture of supercomplex CICIII at 7.8 Å resolution. All observed density can be attributed to the known 80 subunits of the individual complexes, including 132 transmembrane helices. The individual complexes form tight interactions that vary between the architectures, with complex IV subunit COX7a switching contact from complex III to complex I. The arrangement of active sites within the supercomplex may help control reactive oxygen species production. To our knowledge, these are the first complete architectures of the dominant, physiologically relevant state of the electron transport chain.
Editor: England: Nature Publishing Group
Idioma: Inglês

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The architecture of respiratory supercomplexes

Letts, James A ; Fiedorczuk, Karol ; Sazanov, Leonid A

England: Nature Publishing Group

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