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High concentrations of serum interleukin-6 and interleukin-8 in patients with bipolar disorder

Lu, Yun-Rong ; Rao, Ying-Bo ; Mou, Yu-Jian ; Chen, Yan ; Lou, Han-Fen ; Zhang, Yu ; Zhang, Dan-Xuan ; Xie, Hai-Yan ; Hu, Li-Wei ; Fang, Ping

Medicine (Baltimore), 2019-02, Vol.98 (7), p.e14419-e14419 [Periódico revisado por pares]

United States: Wolters Kluwer Health

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  • Título:
    High concentrations of serum interleukin-6 and interleukin-8 in patients with bipolar disorder
  • Autor: Lu, Yun-Rong ; Rao, Ying-Bo ; Mou, Yu-Jian ; Chen, Yan ; Lou, Han-Fen ; Zhang, Yu ; Zhang, Dan-Xuan ; Xie, Hai-Yan ; Hu, Li-Wei ; Fang, Ping
  • Assuntos: Adult ; Biomarkers - blood ; Bipolar Disorder - blood ; C-Reactive Protein - analysis ; Case-Control Studies ; Depressive Disorder, Major - blood ; Female ; Humans ; Interleukin-6 - blood ; Interleukin-8 - blood ; Longitudinal Studies ; Male ; Observational Study ; Retrospective Studies ; Sex Factors
  • É parte de: Medicine (Baltimore), 2019-02, Vol.98 (7), p.e14419-e14419
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Undefined-1
    ObjectType-Feature-3
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  • Descrição: Immune system dysregulation plays a key role in the physiopathology of bipolar disorder (BD) and major depressive disorder (MDD). However, whether interleukins might be biomarkers to distinguish these 2 affective disorders is unclear. Here, we assessed the differences in serum levels of interleukin 6 (IL-6) and interleukin 8 (IL-8) as well as C-reactive protein (CRP) in patients with MDD and BD. In total, we enrolled 21 MDD patients, 26 BD patients, and 20 healthy controls. We collected a total of 35 samples from BD patients in 3 different phases, depression phase, manic phase, and remission stage, and 27 samples from MDD patients in acute and remission phases. Serum IL-6 and IL-8 levels were assessed with solid phase sandwich ELISA-based quantitative arrays, and CRP levels were determined with an automatic analyzer. Both serum IL-6 and IL-8 levels were elevated in BD patients but not MDD patients. Subgroup analysis indicated elevated serum IL-6 in both the depression and manic phases in BD patients. The serum CRP levels did not change in either BD or MDD patients. However, sex differences in CRP concentrations were observed in healthy controls. Furthermore, there were linear correlations between the CRP levels and Bech-Rafaelsen Mania Rating Scale (BRMS) scores in BD patients. IL-6 and IL-8 levels may serve as biomarkers to differentiate between MDD and BD patients, even when the clinical manifestations are atypical. IL-6 may be used for the differential diagnosis of MDD and depressive episodes in BD.
  • Editor: United States: Wolters Kluwer Health
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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