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Minimal clinically-important differences for the “Liverpool Osteoarthritis in Dogs” (LOAD) and the “Canine Orthopedic Index” (COI) in dogs with osteoarthritis

Alves, J. C. ; Innes, John F. Cui, Wenguo

PloS one, 2023-09, Vol.18 (9), p.e0291881-e0291881 [Periódico revisado por pares]

San Francisco: Public Library of Science

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  • Título:
    Minimal clinically-important differences for the “Liverpool Osteoarthritis in Dogs” (LOAD) and the “Canine Orthopedic Index” (COI) in dogs with osteoarthritis
  • Autor: Alves, J. C. ; Innes, John F.
  • Cui, Wenguo
  • Assuntos: Animal diseases ; Arthritis ; Biology and Life Sciences ; Context ; Dogs ; Estimates ; Health services ; Hyaluronic acid ; Joint diseases ; Load distribution ; Mann-Whitney U test ; Medicine and Health Sciences ; Orthopedics ; Osteoarthritis ; Patients ; Physical Sciences ; Quality of life ; Veterinary medicine
  • É parte de: PloS one, 2023-09, Vol.18 (9), p.e0291881-e0291881
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Competing Interests: I have read the journal’s policy, and the authors of this manuscript have the following competing interests: John Innes is co-holder, with the University of Liverpool, of the licence for the LOAD client-reported outcomes measure. LOAD is licensed to Elanco Animal Health.
  • Descrição: Objective Osteoarthritis is the most common joint disease in companion animals. Several client-report outcome measures (CROMs) have been developed and validated to monitor patients and their response to treatment. However, estimates for minimal clinically-important differences for these CROMs in the context of osteoarthritis have not been published. Patients and methods Data from the Clínica Veterinária de Cães (Portuguese Gendarmerie Canine Clinic) clinical records were extracted. Baseline and 30-day post-treatment follow-up data from 296 dogs treated for hip osteoarthritis were categorized based on an anchor question, and estimates of minimal clinically-important differences (MCIDs) using distribution-based and anchor-based methods were performed. Results For the LOAD, the anchor-based methods provided a MCID estimate range of -2.5 to -9.1 and the distribution-based methods from 1.6 to 4.2. For the COI, the anchor-based methods provided a MCID estimate range of -4.5 to -16.6 and the distribution-based methods from 2.3 to 2.4. For the dimensions of COI, values varied from -0.5 to -4.9 with the anchor-based methods and from 0.6 to 2.7 with the distribution-based methods. Receiver operator characteristic curves provided areas under the curve >0.7 for the COI, indicating an acceptable cut-off point, and >0.8 for the LOAD, indicating an excellent cut-off point. Conclusion Our estimates of MCIDs for dogs with OA were consistent with previously proposed values of -4 for the LOAD and -14 for the COI in a post-surgical intervention context. ROC curve data suggest that LOAD may more reliably differentiate between anchor groups. We also presented estimates from COI of -4 for Stiffness, Function, and Gait and -3 for quality of life. These estimates can be used for research and patient monitoring.
  • Editor: San Francisco: Public Library of Science
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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