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TERT proteins contain telomerase conserved motifs

Figueiredo, Luisa M. ; Rocha, Eduardo P. C. ; Mancio-Silva, Liliana ; Prevost, Christine ; Hernandez-Verdun, Danièle ; Scherf, Artur

figshare 2011

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  • Título:
    TERT proteins contain telomerase conserved motifs
  • Autor: Figueiredo, Luisa M. ; Rocha, Eduardo P. C. ; Mancio-Silva, Liliana ; Prevost, Christine ; Hernandez-Verdun, Danièle ; Scherf, Artur
  • Assuntos: Uncategorized
  • Descrição: Copyright information:Taken from "The unusually large telomerase reverse-transcriptase localizes in a discrete compartment associated with the nucleolus"Nucleic Acids Research 2005;33(3):1111-1122.Published online 18 Feb 2005PMCID:PMC549419.© The Author 2005. Published by Oxford University Press. All rights reserved () In-scale diagram showing the difference in size of PfTERT and the homologue, Est2p. Grey boxes represent telomerase-specific motifs: GQ/N, CP, QFP and T. Black boxes represent RT motifs. () Multiple sequence alignment of the conserved motifs of all TERT proteins described to date and the four Plasmodium TERT proteins identified in this work: PbTERT (), PfTERT (), PkTERT () and PyTERT (). For a given position within the alignment, identical or similar amino acids to the consensus sequence are shaded in black or grey, respectively. : The putative gene was excluded because it lacks all TERT-specific motifs. Squares mark telomerase-specific amino acids that are not present in viral RTs; circles indicate amino acids essential for RT activity. The numbers accompanying each protein aligned in (B) represent the number of amino acids that exist between two motifs, or between a terminal motif and the protein end. When an N- or C-terminus is unknown, the amino acid distance is shown as ‘xxx’. Motifs CP and T have not been found in and accordingly are absent from these alignments. At, ; Ca, ; Ea, ; Gl, ; Hs, ; Mm, ; Ot, ; Sc, ; Sp, ; Tt, ; Xl, ; Pb, ; Pf, ; Pk, ; and Py, .
  • Editor: figshare
  • Data de criação/publicação: 2011
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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