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Human commensal gut Proteobacteria withstand type VI secretion attacks through immunity protein-independent mechanisms

Flaugnatti, Nicolas ; Isaac, Sandrine ; Lemos Rocha, Leonardo F. ; Stutzmann, Sandrine ; Rendueles, Olaya ; Stoudmann, Candice ; Vesel, Nina ; Garcia-Garcera, Marc ; Buffet, Amandine ; Sana, Thibault G. ; Rocha, Eduardo P. C. ; Blokesch, Melanie

Nature communications, 2021-10, Vol.12 (1), p.5751-5751, Article 5751 [Periódico revisado por pares]

London: Nature Publishing Group

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Título:
Human commensal gut Proteobacteria withstand type VI secretion attacks through immunity protein-independent mechanisms
Autor: Flaugnatti, Nicolas ; Isaac, Sandrine ; Lemos Rocha, Leonardo F. ; Stutzmann, Sandrine ; Rendueles, Olaya ; Stoudmann, Candice ; Vesel, Nina ; Garcia-Garcera, Marc ; Buffet, Amandine ; Sana, Thibault G. ; Rocha, Eduardo P. C. ; Blokesch, Melanie
Assuntos: Bacteria ; Bacteriology ; Biochemistry, Molecular Biology ; Capsular polysaccharides ; Cholera ; Colonization ; Diarrhea ; Digestive system ; Digestive tract ; Enterobacter cloacae ; Genomics ; Human health and pathology ; Immunity ; Infections ; Intestinal microflora ; Klebsiella ; Life Sciences ; Microbiology and Parasitology ; Microbiota ; Polysaccharides ; Proteins ; Proteobacteria ; Saccharides ; Tissues and Organs ; Vibrio cholerae ; Virulence ; Virulence factors ; Waterborne diseases
É parte de: Nature communications, 2021-10, Vol.12 (1), p.5751-5751, Article 5751
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SourceType-Scholarly Journals-1
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Descrição: Abstract While the major virulence factors for Vibrio cholerae , the cause of the devastating diarrheal disease cholera, have been extensively studied, the initial intestinal colonization of the bacterium is not well understood because non-human adult animals are refractory to its colonization. Recent studies suggest the involvement of an interbacterial killing device known as the type VI secretion system (T6SS). Here, we tested the T6SS-dependent interaction of V. cholerae with a selection of human gut commensal isolates. We show that the pathogen efficiently depleted representative genera of the Proteobacteria in vitro, while members of the Enterobacter cloacae complex and several Klebsiella species remained unaffected. We demonstrate that this resistance against T6SS assaults was mediated by the production of superior T6SS machinery or a barrier exerted by group I capsules. Collectively, our data provide new insights into immunity protein-independent T6SS resistance employed by the human microbiota and colonization resistance in general.
Editor: London: Nature Publishing Group
Idioma: Inglês

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Human commensal gut Proteobacteria withstand type VI secretion attacks through immunity protein-independent mechanisms

Flaugnatti, Nicolas ; Isaac, Sandrine ; Lemos Rocha, Leonardo F. ; Stutzmann, Sandrine ; Rendueles, Olaya ; Stoudmann, Candice ; Vesel, Nina ; Garcia-Garcera, Marc ; Buffet, Amandine ; Sana, Thibault G. ; Rocha, Eduardo P. C. ; Blokesch, Melanie

London: Nature Publishing Group

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