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1-Deoxymannojirimycin inhibits Golgi-mediated processing of glycoprotein in Xenopus oocytes

Fabbrini, Maria Serena ; Zoppè, Monica ; Bollini, Roberto ; Vitale, Alessandro

FEBS letters, 1988-07, Vol.234 (2), p.489-492 [Periódico revisado por pares]

Amsterdam: Elsevier B.V

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Título:
1-Deoxymannojirimycin inhibits Golgi-mediated processing of glycoprotein in Xenopus oocytes
Autor: Fabbrini, Maria Serena ; Zoppè, Monica ; Bollini, Roberto ; Vitale, Alessandro
Assuntos: 1-Deoxymannojirimycin ; 1-Deoxynojirimycin ; Animals ; Biological and medical sciences ; Female ; Fundamental and applied biological sciences. Psychology ; Glucosamine - analogs & derivatives ; Glucosamine - pharmacology ; Glycoprotein processing ; Glycoproteins - genetics ; Golgi Apparatus - drug effects ; Golgi Apparatus - metabolism ; Golgi complex ; Molecular and cellular biology ; Molecular genetics ; Oocyte ; Oocytes - drug effects ; Oocytes - metabolism ; Phytohemagglutinin ; Protein Biosynthesis ; RNA, Messenger - genetics ; Translation. Translation factors. Protein processing ; Xenopus ; Xenopus laevis
É parte de: FEBS letters, 1988-07, Vol.234 (2), p.489-492
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: We prepared in vitro an mRNA transcript coding for the erythroagglutinating subunit of the kidney bean glycoprotein phytohemagglutinin, E-PHA. The mRNA, injected into Xenopus oocytes, synthesized E-PHA carrying two Asn-linked carbohydrate chains, one of which was processed and acquired resistance to endo-β- N-acetylglucosaminidase H, as occurs in the native bean cells. When the mannose analog 1-deoxymannojirimycin, an inhibitor of mammalian Golgi mannosidase I, was included in the oocyte culture medium, the acquisition of endo-β- N-acetylglucosaminidase H resistance was abolished, indicating that also in an amphibian cell the inhibitor blocks a key reaction in Golgi-mediated processing.
Editor: Amsterdam: Elsevier B.V
Idioma: Inglês

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1-Deoxymannojirimycin inhibits Golgi-mediated processing of glycoprotein in Xenopus oocytes

Fabbrini, Maria Serena ; Zoppè, Monica ; Bollini, Roberto ; Vitale, Alessandro

Amsterdam: Elsevier B.V

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