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Age-related alteration of expression and function of TLRs and NK activity in oral candidiasis

Oouchi, M ; Hasebe, A ; Hata, H ; Segawa, T ; Yamazaki, Y ; Yoshida, Y ; Kitagawa, Y ; Shibata, K-I

Oral diseases, 2015-07, Vol.21 (5), p.645-651 [Periódico revisado por pares]

Denmark: Blackwell Publishing Ltd

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Título:
Age-related alteration of expression and function of TLRs and NK activity in oral candidiasis
Autor: Oouchi, M ; Hasebe, A ; Hata, H ; Segawa, T ; Yamazaki, Y ; Yoshida, Y ; Kitagawa, Y ; Shibata, K-I
Assuntos: Adult ; Age ; Age Factors ; Aged ; Aged, 80 and over ; Candida albicans - isolation & purification ; Candidiasis, Oral - immunology ; Candidiasis, Oral - microbiology ; Dentistry ; Disease Progression ; Down-Regulation ; Female ; Flow Cytometry ; Fungal infections ; Humans ; Killer Cells, Natural - immunology ; Killer Cells, Natural - metabolism ; Leukocytes, Mononuclear - immunology ; Leukocytes, Mononuclear - metabolism ; Male ; Middle Aged ; natural killer cell activity ; oral candidiasis ; Oral diseases ; toll-like receptors ; Toll-Like Receptors - biosynthesis ; Toll-Like Receptors - immunology ; Toll-Like Receptors - metabolism
É parte de: Oral diseases, 2015-07, Vol.21 (5), p.645-651
Notas: ark:/67375/WNG-P2RQBHRL-5
ArticleID:ODI12329
Ministry of Education, Culture, Sports, Science and Technology - No. B23792305
istex:E9DAAE52FD42777A58858EFD8107E50C461AE757
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Objective Roles of aging or immune responses mediated by Toll‐like receptors and natural killer cell in the onset or progression of human candidiasis remain unclear. This study was designed to elucidate the roles using peripheral blood mononuclear cells from healthy donors and patients with oral candidiasis. Subjects and methods Subjects tested were healthy volunteers and patients who visited Dental Clinical Division of Hokkaido University Hospital. The patients with oral candidiasis included 39 individuals (25–89 years of age) with major complaints on pain in oral mucosa and/or dysgeusia. Healthy volunteers include students (25–35 years of age) and teaching staffs (50–65 years of age) of Hokkaido University Graduate School of Dental Medicine. Results Functions of Toll‐like receptors 2 and 4 were downregulated significantly and the natural killer activity was slightly, but not significantly downregulated in aged healthy volunteers compared with healthy young volunteers. Functions of Toll‐like receptors 2 and 4 and the natural killer activity were significantly downregulated in patients with oral candidiasis compared with healthy volunteers. Conclusion Downregulation of functions of Toll‐like receptors 2 and 4 as well as natural killer activity is suggested to be associated with the onset or progression of oral candidiasis in human.
Editor: Denmark: Blackwell Publishing Ltd
Idioma: Inglês

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Age-related alteration of expression and function of TLRs and NK activity in oral candidiasis

Oouchi, M ; Hasebe, A ; Hata, H ; Segawa, T ; Yamazaki, Y ; Yoshida, Y ; Kitagawa, Y ; Shibata, K-I

Denmark: Blackwell Publishing Ltd

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