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Alpha-Actinin-3 R577X Polymorphism Influences Muscle Damage and Hormonal Responses After a Soccer Game

Coelho, Daniel B ; Pimenta, Eduardo M ; Rosse, Izinara C ; Veneroso, Christiano ; Pussieldi, Guilherme De Azambuja ; Becker, Lenice K ; Oliveira, Emerson C ; Carvalho, Maria R.S ; Silami-Garcia, Emerson

Journal of strength and conditioning research, 2019-10, Vol.33 (10), p.2655-2664 [Periódico revisado por pares]

United States: Copyright by the National Strength & Conditioning Association

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Alpha-Actinin-3 R577X Polymorphism Influences Muscle Damage and Hormonal Responses After a Soccer Game
Autor: Coelho, Daniel B ; Pimenta, Eduardo M ; Rosse, Izinara C ; Veneroso, Christiano ; Pussieldi, Guilherme De Azambuja ; Becker, Lenice K ; Oliveira, Emerson C ; Carvalho, Maria R.S ; Silami-Garcia, Emerson
Assuntos: Actin ; Actinin ; Actinin - blood ; Actinin - genetics ; Adolescent ; Alleles ; Cortisol ; Creatine ; Creatine kinase ; Creatine Kinase - blood ; Gene Expression ; Gene polymorphism ; Genotype ; Humans ; Hydrocortisone - blood ; Interleukin 6 ; Interleukin-6 - blood ; Menopause ; Muscle strength ; Muscle, Skeletal - pathology ; Polymorphism, Genetic ; Soccer ; Soccer - physiology ; Testosterone ; Testosterone - blood
É parte de: Journal of strength and conditioning research, 2019-10, Vol.33 (10), p.2655-2664
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: ABSTRACTCoelho, DB, Pimenta, EM, Rosse, IC, Veneroso, C, Pussieldi, GDA, Becker, LK, De Oliveira, EC, Carvalho, MRS, and Silami-Garcia, E. Alpha-actinin-3 R577X polymorphism influences muscle damage and hormonal responses after a soccer game. J Strength Cond Res 33(10)2655–2664, 2019—The purpose of this study was to evaluate indicators of muscle damage and hormonal responses after soccer matches and its relation to alpha-actinin-3 (ACTN3) gene expression (XX vs. RR/RX), considering that the R allele produces alpha-actinin-3 and provides greater muscle strength and power. Thirty players (10 XX and 20 RR/RX) younger than 16 years were evaluated in this study. Blood samples were collected immediately before, after, 2, and 4 hours after the games to assess muscle damage (creatine kinase [CK] and alpha-actin) and hormonal responses (interleukin-6 [IL-6], cortisol, and testosterone). Postgame CK was higher as compared to the pregame values in both groups and it was also higher in the RR/RX (p < 0.05) than in the XX. The concentrations of alpha-actin and IL-6 were similar for both groups and did not change over time. Testosterone was increased after the game only in the RR/RX group (p < 0.05). Cortisol concentrations in group RR/RX were higher immediately after the game than before the game, and 2 and 4 hours after the game the concentration decreased (p < 0.05). The RR and RX individuals presented higher markers of muscle microtrauma and hormonal stress, probably because they performed more speed and power actions during the game, which is a self-regulated activity. From the different responses presented by RR/RX and XX genotypes, we conclude that the genotypic profile should be taken into account when planning training workloads and recovery of athletes.
Editor: United States: Copyright by the National Strength & Conditioning Association
Idioma: Inglês

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Alpha-Actinin-3 R577X Polymorphism Influences Muscle Damage and Hormonal Responses After a Soccer Game

Coelho, Daniel B ; Pimenta, Eduardo M ; Rosse, Izinara C ; Veneroso, Christiano ; Pussieldi, Guilherme De Azambuja ; Becker, Lenice K ; Oliveira, Emerson C ; Carvalho, Maria R.S ; Silami-Garcia, Emerson

United States: Copyright by the National Strength & Conditioning Association

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