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Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes

van der Meer, Dennis ; Rokicki, Jaroslav ; Kaufmann, Tobias ; Córdova-Palomera, Aldo ; Moberget, Torgeir ; Alnæs, Dag ; Bettella, Francesco ; Frei, Oleksandr ; Doan, Nhat Trung ; Sønderby, Ida E ; Smeland, Olav B ; Agartz, Ingrid ; Bertolino, Alessandro ; Bralten, Janita ; Brandt, Christine L ; Buitelaar, Jan K ; Djurovic, Srdjan ; van Donkelaar, Marjolein ; Dørum, Erlend S ; Espeseth, Thomas ; Faraone, Stephen V ; Fernández, Guillén ; Fisher, Simon E ; Franke, Barbara ; Haatveit, Beathe ; Hartman, Catharina A ; Hoekstra, Pieter J ; Håberg, Asta K ; Jönsson, Erik G ; Kolskår, Knut K ; Le Hellard, Stephanie ; Lund, Martina J ; Lundervold, Astri J ; Lundervold, Arvid ; Melle, Ingrid ; Monereo Sánchez, Jennifer ; Norbom, Linn C ; Nordvik, Jan E ; Nyberg, Lars ; Oosterlaan, Jaap ; Papalino, Marco ; Papassotiropoulos, Andreas ; Pergola, Giulio ; de Quervain, Dominique J F ; Richard, Geneviève ; Sanders, Anne-Marthe ; Selvaggi, Pierluigi ; Shumskaya, Elena ; Steen, Vidar M ; Tønnesen, Siren ; Ulrichsen, Kristine M ; Zwiers, Marcel P ; Andreassen, Ole A ; Westlye, Lars T

Molecular psychiatry, 2020-11, Vol.25 (11), p.3053-3065 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes
Autor: van der Meer, Dennis ; Rokicki, Jaroslav ; Kaufmann, Tobias ; Córdova-Palomera, Aldo ; Moberget, Torgeir ; Alnæs, Dag ; Bettella, Francesco ; Frei, Oleksandr ; Doan, Nhat Trung ; Sønderby, Ida E ; Smeland, Olav B ; Agartz, Ingrid ; Bertolino, Alessandro ; Bralten, Janita ; Brandt, Christine L ; Buitelaar, Jan K ; Djurovic, Srdjan ; van Donkelaar, Marjolein ; Dørum, Erlend S ; Espeseth, Thomas ; Faraone, Stephen V ; Fernández, Guillén ; Fisher, Simon E ; Franke, Barbara ; Haatveit, Beathe ; Hartman, Catharina A ; Hoekstra, Pieter J ; Håberg, Asta K ; Jönsson, Erik G ; Kolskår, Knut K ; Le Hellard, Stephanie ; Lund, Martina J ; Lundervold, Astri J ; Lundervold, Arvid ; Melle, Ingrid ; Monereo Sánchez, Jennifer ; Norbom, Linn C ; Nordvik, Jan E ; Nyberg, Lars ; Oosterlaan, Jaap ; Papalino, Marco ; Papassotiropoulos, Andreas ; Pergola, Giulio ; de Quervain, Dominique J F ; Richard, Geneviève ; Sanders, Anne-Marthe ; Selvaggi, Pierluigi ; Shumskaya, Elena ; Steen, Vidar M ; Tønnesen, Siren ; Ulrichsen, Kristine M ; Zwiers, Marcel P ; Andreassen, Ole A ; Westlye, Lars T
Assuntos: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Alzheimer Disease - diagnostic imaging ; Alzheimer Disease - genetics ; Alzheimer Disease - pathology ; Alzheimer's disease ; Animal behavior ; Association analysis ; Brain ; Brain architecture ; Child ; Child, Preschool ; Female ; Gene polymorphism ; Genetic aspects ; Genome-Wide Association Study ; Genomes ; Genomics ; Heritability ; Hippocampus ; Hippocampus - anatomy & histology ; Hippocampus - diagnostic imaging ; Hippocampus - metabolism ; Hippocampus - pathology ; Humans ; Male ; Medical colleges ; Medicin och hälsovetenskap ; Mental disorders ; Middle Aged ; Navigation behavior ; Nervous system ; Neurodegenerative diseases ; Neuroimaging ; Neurosciences ; Polymorphism, Single Nucleotide - genetics ; Schizophrenia ; Schizophrenia - diagnostic imaging ; Schizophrenia - genetics ; Schizophrenia - pathology ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism ; Spatial memory ; Structure-function relationships ; Young Adult
É parte de: Molecular psychiatry, 2020-11, Vol.25 (11), p.3053-3065
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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NFR/229671
Descrição: The hippocampus is a heterogeneous structure, comprising histologically distinguishable subfields. These subfields are differentially involved in memory consolidation, spatial navigation and pattern separation, complex functions often impaired in individuals with brain disorders characterized by reduced hippocampal volume, including Alzheimer's disease (AD) and schizophrenia. Given the structural and functional heterogeneity of the hippocampal formation, we sought to characterize the subfields' genetic architecture. T1-weighted brain scans (n = 21,297, 16 cohorts) were processed with the hippocampal subfields algorithm in FreeSurfer v6.0. We ran a genome-wide association analysis on each subfield, co-varying for whole hippocampal volume. We further calculated the single-nucleotide polymorphism (SNP)-based heritability of 12 subfields, as well as their genetic correlation with each other, with other structural brain features and with AD and schizophrenia. All outcome measures were corrected for age, sex and intracranial volume. We found 15 unique genome-wide significant loci across six subfields, of which eight had not been previously linked to the hippocampus. Top SNPs were mapped to genes associated with neuronal differentiation, locomotor behaviour, schizophrenia and AD. The volumes of all the subfields were estimated to be heritable (h2 from 0.14 to 0.27, all p < 1 × 10 ) and clustered together based on their genetic correlations compared with other structural brain features. There was also evidence of genetic overlap of subicular subfield volumes with schizophrenia. We conclude that hippocampal subfields have partly distinct genetic determinants associated with specific biological processes and traits. Taking into account this specificity may increase our understanding of hippocampal neurobiology and associated pathologies.
Editor: England: Nature Publishing Group
Idioma: Inglês;Norueguês

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Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes

England: Nature Publishing Group

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