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The Role of iNOS and PHOX in Periapical Bone Resorption

Silva, M.J.B. ; Sousa, L.M.A. ; Lara, V.P.L. ; Cardoso, F.P. ; Júnior, G.M. ; Totola, A.H. ; Caliari, M.V. ; Romero, O.B. ; Silva, G.A.B. ; Ribeiro-Sobrinho, A.P. ; Vieira, L.Q.

Journal of dental research, 2011-04, Vol.90 (4), p.495-500 [Periódico revisado por pares]

Los Angeles, CA: SAGE Publications

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Título:
The Role of iNOS and PHOX in Periapical Bone Resorption
Autor: Silva, M.J.B. ; Sousa, L.M.A. ; Lara, V.P.L. ; Cardoso, F.P. ; Júnior, G.M. ; Totola, A.H. ; Caliari, M.V. ; Romero, O.B. ; Silva, G.A.B. ; Ribeiro-Sobrinho, A.P. ; Vieira, L.Q.
Assuntos: Acid phosphatase (tartrate-resistant) ; Acid Phosphatase - analysis ; Alveolar Bone Loss - enzymology ; Alveolar Bone Loss - metabolism ; Alveolar Bone Loss - pathology ; Animals ; Antimicrobial agents ; Biological and medical sciences ; Biomarkers - analysis ; Bone resorption ; Chemokine CCL2 - analysis ; Cytokines ; Cytokines - analysis ; Dentistry ; Disease Models, Animal ; Disease Progression ; Facial bones, jaws, teeth, parodontium: diseases, semeiology ; IL-1β ; Infections ; Inflammation ; Inflammation Mediators - analysis ; Interleukin-1beta - analysis ; Isoenzymes - analysis ; Lesions ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Mice, Inbred Strains ; Mice, Knockout ; Monocyte chemoattractant protein 1 ; NADPH Oxidases - physiology ; Nitric oxide ; Nitric Oxide - physiology ; Nitric Oxide Synthase Type II - physiology ; Nitric-oxide synthase ; Non tumoral diseases ; Otorhinolaryngology. Stomatology ; Periapical Periodontitis - enzymology ; Periapical Periodontitis - pathology ; Periodontal ligament ; Periodontal Ligament - enzymology ; Periodontal Ligament - pathology ; Periodontitis ; Phagocytes - enzymology ; RANK Ligand - analysis ; Reactive oxygen species ; Reactive Oxygen Species - pharmacology ; Receptor Activator of Nuclear Factor-kappa B - analysis ; Rodents ; Tartrate-Resistant Acid Phosphatase ; TRANCE protein ; Tumor Necrosis Factor-alpha - analysis ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α
É parte de: Journal of dental research, 2011-04, Vol.90 (4), p.495-500
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Descrição: Nitric oxide (NO) and reactive oxygen species (ROS) are key molecules in resistance to pathogens. Little is known about their role in pathogenesis of periapical lesions. To address this issue, we induced periapical lesions in mice lacking nitric oxide synthase (iNOS-/-) or phagocyte oxidase (PHOX-/-). iNOS-/- mice expressed higher levels of IL-1β, TNF-α, RANK, RANKL, and MCP-1 than C57BL/6 and PHOX-/-. Apical thickening of the periodontal ligament was also greater in iNOS-/- compared with other groups. Interestingly, ROS production did not interfere in periapical lesion progression, but seemed to be essential for the appearance of multinucleated TRAP-positive cells. Thus, periapical lesion progression in iNOS-/- was associated with an imbalance of pro-inflammatory cytokines (IL-1β and TNF-α), bone-resorptive modulators (RANK and RANKL), and MCP-1. We conclude that NO, but not ROS, controls progression of bone resorption in a murine experimental model of apical periodontitis.
Editor: Los Angeles, CA: SAGE Publications
Idioma: Inglês

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The Role of iNOS and PHOX in Periapical Bone Resorption

Silva, M.J.B. ; Sousa, L.M.A. ; Lara, V.P.L. ; Cardoso, F.P. ; Júnior, G.M. ; Totola, A.H. ; Caliari, M.V. ; Romero, O.B. ; Silva, G.A.B. ; Ribeiro-Sobrinho, A.P. ; Vieira, L.Q.

Los Angeles, CA: SAGE Publications

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