skip to main content
Idioma:
Primo Search
Clear Search Box
Search in: Busca Geral
Busca Avançada
Busca por Índices

Lung function trajectories and bronchial hyperresponsiveness during childhood following severe RSV bronchiolitis in infancy

Kitcharoensakkul, Maleewan ; Bacharier, Leonard B. ; Schweiger, Toni L. ; Wilson, Brad ; Goss, Charles W ; Lew, Daphne ; Schechtman, Kenneth B. ; Castro, Mario ; Kalaycı, Ömer Kalaycı, Ömer

Pediatric allergy and immunology, 2021-04, Vol.32 (3), p.457-464 [Periódico revisado por pares]

England: Wiley Subscription Services, Inc

Texto completo disponível

Citações Citado por
  • Título:
    Lung function trajectories and bronchial hyperresponsiveness during childhood following severe RSV bronchiolitis in infancy
  • Autor: Kitcharoensakkul, Maleewan ; Bacharier, Leonard B. ; Schweiger, Toni L. ; Wilson, Brad ; Goss, Charles W ; Lew, Daphne ; Schechtman, Kenneth B. ; Castro, Mario ; Kalaycı, Ömer
  • Kalaycı, Ömer
  • Assuntos: Age ; Asthma ; bronchial hyperreactivity ; Bronchial Hyperreactivity - diagnosis ; Bronchiolitis ; Bronchiolitis, Viral - diagnosis ; Bronchopneumonia ; Child ; Children ; Follow-Up Studies ; Humans ; Hyperreactivity ; Infant ; Infants ; longitudinal changes ; Lung ; lung function ; Lungs ; Male ; Methacholine ; Prospective Studies ; Respiratory function ; Respiratory syncytial virus ; Respiratory Syncytial Virus Infections - complications ; Respiratory Syncytial Virus Infections - diagnosis ; spirometry
  • É parte de: Pediatric allergy and immunology, 2021-04, Vol.32 (3), p.457-464
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    AUTHOR CONTRIBUTION
    Maleewan Kitcharoensakkul: Data curation (supporting); Formal analysis (supporting); Writing-original draft (lead); Writing-review & editing (lead). Leonard B Bacharier: Conceptualization (lead); Data curation (lead); Formal analysis (supporting); Funding acquisition (lead); Investigation (lead); Methodology (lead); Project administration (lead); Supervision (lead); Validation (lead); Writing-review & editing (supporting). Toni L Schweiger: Project administration (supporting); Writing-review & editing (supporting). Brad Wilson: Formal analysis (lead); Resources (lead); Software (lead); Validation (lead); Writing-review & editing (supporting). Charles W Goss: Formal analysis (lead); Software (lead); Validation (lead); Writing-review & editing (supporting). Daphne Lew: Formal analysis (supporting); Validation (supporting). Kenneth B Schechtman: Conceptualization (supporting); Formal analysis (supporting); Investigation (supporting); Methodology (supporting); Resources (supporting); Supervision (supporting); Validation (supporting); Writing-review & editing (supporting). Mario Castro: Conceptualization (lead); Data curation (lead); Formal analysis (lead); Funding acquisition (lead); Investigation (lead); Methodology (lead); Project administration (lead); Resources (lead); Supervision (lead); Validation (lead); Writing-review & editing (lead).
  • Descrição: Background Children with severe respiratory syncytial virus (RSV) bronchiolitis in infancy have increased risks of asthma and reduced lung function in later life. There are limited studies on the longitudinal changes of lung function and bronchial hyperreactivity from early to late childhood in infants hospitalized for RSV bronchiolitis. Methods In a prospective cohort of 206 children with their first episode of RSV‐confirmed bronchiolitis in the first year of life, 122 had spirometry performed at least twice between 5‐16 years of age. Methacholine bronchoprovocation was available in 127 and 79 children at 7 and 12 years of age, respectively. Longitudinal changes in FEV1, FVC, and FEV1/FVC z‐scores and methacholine PC20 were analyzed. Results 55% of the study cohort (N = 122) were male, and 55% were Caucasian. During follow‐up, longitudinal changes in z‐scores for pre‐ and post‐bronchodilator FEV1 (P < .0001) FVC (P < .0001) and FEV1/FVC (P < .0001 for pre‐ and 0.007 for post‐bronchodilator) from age 5 to 10‐16 years were observed. Declined lung function in late childhood was significantly associated with gender, physician diagnosis of asthma, and allergic sensitization. PC20 geometric mean increased from 0.28 mg/mL at 7 years to 0.53 mg/mL at 12 years of age, and the frequency of abnormal bronchial hyperreactivity decreased from 96% to 78% (P = .0003). Conclusions Following severe RSV bronchiolitis, there appear to be significant longitudinal changes in pre‐ and post‐bronchodilator lung function during childhood. The study has several limitations including significant dropouts and the lack of a control group and post‐bronchodilator measurements. Bronchial hyperreactivity is common in children following severe RSV bronchiolitis; however, it appears to decrease as they enter late childhood.
  • Editor: England: Wiley Subscription Services, Inc
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.