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Distinct Features and Functions of Systemic and Mucosal Humoral Immunity Among SARS-CoV-2 Convalescent Individuals

Butler, Savannah E ; Crowley, Andrew R ; Natarajan, Harini ; Xu, Shiwei ; Weiner, Joshua A ; Bobak, Carly A ; Mattox, Daniel E ; Lee, Jiwon ; Wieland-Alter, Wendy ; Connor, Ruth I ; Wright, Peter F ; Ackerman, Margaret E

Frontiers in immunology, 2021-01, Vol.11, p.618685-618685 [Periódico revisado por pares]

Switzerland: Frontiers Media S.A

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Título:
Distinct Features and Functions of Systemic and Mucosal Humoral Immunity Among SARS-CoV-2 Convalescent Individuals
Autor: Butler, Savannah E ; Crowley, Andrew R ; Natarajan, Harini ; Xu, Shiwei ; Weiner, Joshua A ; Bobak, Carly A ; Mattox, Daniel E ; Lee, Jiwon ; Wieland-Alter, Wendy ; Connor, Ruth I ; Wright, Peter F ; Ackerman, Margaret E
Assuntos: Adolescent ; Adult ; Aged ; Antibodies, Neutralizing - immunology ; Antibodies, Viral - immunology ; antibody ; Antibody-Dependent Cell Cytotoxicity - immunology ; Convalescence ; COVID-19 - immunology ; Female ; Humans ; IgA ; IgG ; Immunity, Humoral - immunology ; Immunity, Mucosal - immunology ; Immunoglobulin A - immunology ; Immunoglobulin G - immunology ; Immunology ; Male ; Middle Aged ; mucosal immunity ; Nasal Mucosa - immunology ; neutralization ; SARS-CoV-2 ; SARS-CoV-2 - immunology ; Young Adult
É parte de: Frontiers in immunology, 2021-01, Vol.11, p.618685-618685
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
Edited by: Francesca Chiodi, Karolinska Institutet (KI), Sweden
These authors have contributed equally to this work
Reviewed by: Marianne Jansson, Lund University, Sweden; Lucia Lopalco, San Raffaele Hospital (IRCCS), Italy
This article was submitted to Viral Immunology, a section of the journal Frontiers in Immunology
Descrição: Understanding humoral immune responses to SARS-CoV-2 infection will play a critical role in the development of vaccines and antibody-based interventions. We report systemic and mucosal antibody responses in convalescent individuals who experienced varying severity of disease. Whereas assessment of neutralization and antibody-mediated effector functions revealed polyfunctional antibody responses in serum, only robust neutralization and phagocytosis were apparent in nasal wash samples. Serum neutralization and effector functions correlated with systemic SARS-CoV-2-specific IgG response magnitude, while mucosal neutralization was associated with nasal SARS-CoV-2-specific IgA. Antibody depletion experiments support the mechanistic relevance of these correlations. Associations between nasal IgA responses, virus neutralization at the mucosa, and less severe disease suggest the importance of assessing mucosal immunity in larger natural infection cohorts. Further characterization of antibody responses at the portal of entry may define their ability to contribute to protection from infection or reduced risk of hospitalization, informing public health assessment strategies and vaccine development efforts.
Editor: Switzerland: Frontiers Media S.A
Idioma: Inglês

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Distinct Features and Functions of Systemic and Mucosal Humoral Immunity Among SARS-CoV-2 Convalescent Individuals

Butler, Savannah E ; Crowley, Andrew R ; Natarajan, Harini ; Xu, Shiwei ; Weiner, Joshua A ; Bobak, Carly A ; Mattox, Daniel E ; Lee, Jiwon ; Wieland-Alter, Wendy ; Connor, Ruth I ; Wright, Peter F ; Ackerman, Margaret E

Switzerland: Frontiers Media S.A

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