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Single-cell transcriptional landscapes of bovine peri-implantation development

Scatolin, Giovanna Nascimento ; Ming, Hao ; Wang, Yinjuan ; Iyyappan, Rajan ; Gutierrez-Castillo, Emilio ; Zhu, Linkai ; Sagheer, Masroor ; Song, Chao ; Bondioli, Kenneth ; Jiang, Zongliang

iScience, 2024-04, Vol.27 (4), p.109605-109605, Article 109605 [Periódico revisado por pares]

United States: Elsevier Inc

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  • Título:
    Single-cell transcriptional landscapes of bovine peri-implantation development
  • Autor: Scatolin, Giovanna Nascimento ; Ming, Hao ; Wang, Yinjuan ; Iyyappan, Rajan ; Gutierrez-Castillo, Emilio ; Zhu, Linkai ; Sagheer, Masroor ; Song, Chao ; Bondioli, Kenneth ; Jiang, Zongliang
  • Assuntos: Dairy cattle embryology ; Embryology ; Expression study ; Transcriptomics
  • É parte de: iScience, 2024-04, Vol.27 (4), p.109605-109605, Article 109605
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Present address: Breeding and Reproduction of the Ministry of Agriculture and Rural Affairs, National Engineering Laboratory for Animal Science and Technology, China Agricultural University, Beijing, 100193, P.R. China
    These authors contributed equally
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  • Descrição: Supporting healthy pregnancy outcomes requires a comprehensive understanding of the molecular and cellular programs of peri-implantation development, when most pregnancy failure occurs. Here, we present single-cell transcriptomes of bovine peri-implantation embryo development at day 12, 14, 16, and 18 post-fertilization. We defined the cellular composition and gene expression of embryonic disc, hypoblast, and trophoblast lineages in bovine peri-implantation embryos, and identified markers and pathway signaling that represent distinct stages of bovine peri-implantation lineages; the expression of selected markers was validated in peri-implantation embryos. Using detailed time-course transcriptomic analyses, we revealed a previously unrecognized primitive trophoblast cell lineage. We also characterized conserved and divergence peri-implantation lineage programs between bovine and other mammalian species. Finally, we established cell-cell communication signaling underlies embryonic and extraembryonic cell interaction to ensure proper early development. These data provide foundational information to discover essential biological signaling underpinning bovine peri-implantation development. [Display omitted] •ScRNAseq analysis of peri-implantation reveals an unrecognized primitive trophoblast•Peri-implantation cell programs between bovine and other mammalian species are compared•Novel lineage markers are identified and validated•Cell-cell communication underlies embryonic and extraembryonic cell interaction Dairy cattle embryology; Embryology; Expression study; Transcriptomics
  • Editor: United States: Elsevier Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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