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Sensing Lipids with Mincle: Structure and Function

Williams, Spencer J

Frontiers in immunology, 2017-11, Vol.8, p.1662-1662 [Periódico revisado por pares]

Switzerland: Frontiers Research Foundation

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  • Título:
    Sensing Lipids with Mincle: Structure and Function
  • Autor: Williams, Spencer J
  • Assuntos: adjuvant ; C-type lectin receptor ; Cell receptors ; cell-mediated immunity ; glycolipids ; Immunology ; Ligands (Biochemistry) ; Lipids ; Mincle ; Properties ; structure–activity relationship
  • É parte de: Frontiers in immunology, 2017-11, Vol.8, p.1662-1662
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
    Reviewed by: Jérôme Nigou, Centre national de la recherche scientifique (CNRS), France; Robert Adam Harris, Karolinska Institute (KI), Sweden
    Specialty section: This article was submitted to Molecular Innate Immunity, a section of the journal Frontiers in Immunology
    Edited by: Roland Lang, Universitätsklinikum Erlangen, Germany
  • Descrição: Mincle is a C-type lectin receptor that has emerged as an important player in innate immunity through its capacity to recognize a wide range of lipidic species derived from damaged/altered self and foreign microorganisms. Self-ligands include sterols (e.g., cholesterol), and β-glucosylceramides, and the protein SAP130, which is released upon cell death. Foreign lipids comprise those from both microbial pathogens and commensals and include glycerol, glucose and trehalose mycolates, and glycosyl diglycerides. A large effort has focused on structural variation of these ligands to illuminate the structure-activity relationships required for the agonism of signaling though Mincle and has helped identify key differences in ligand recognition between human and rodent Mincle. These studies in turn have helped identify new Mincle ligands, further broadening our understanding of the diversity of organisms and lipidic species recognized by Mincle. Finally, progress toward the development of Mincle agonists as vaccine adjuvants providing humoral and cell-mediated immunity with reduced toxicity is discussed.
  • Editor: Switzerland: Frontiers Research Foundation
  • Idioma: Inglês
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