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Bioactive secondary metabolites from Phomopsis sp., an endophytic fungus from Senna spectabilis

Chapla, Vanessa Mara ; Zeraik, Maria Luiza ; Ximenes, Valdecir F ; Zanardi, Lisinéia Maria ; Lopes, Márcia N ; Cavalheiro, Alberto José ; Silva, Dulce Helena S ; Young, Maria Cláudia M ; Fonseca, Luiz Marcos da ; Bolzani, Vanderlan S ; Araújo, Angela Regina

Molecules (Basel, Switzerland), 2014-05, Vol.19 (5), p.6597-6608 [Periódico revisado por pares]

Switzerland: MDPI

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Título:
Bioactive secondary metabolites from Phomopsis sp., an endophytic fungus from Senna spectabilis
Autor: Chapla, Vanessa Mara ; Zeraik, Maria Luiza ; Ximenes, Valdecir F ; Zanardi, Lisinéia Maria ; Lopes, Márcia N ; Cavalheiro, Alberto José ; Silva, Dulce Helena S ; Young, Maria Cláudia M ; Fonseca, Luiz Marcos da ; Bolzani, Vanderlan S ; Araújo, Angela Regina
Assuntos: Anti-Inflammatory Agents, Non-Steroidal - chemistry ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Antifungal Agents - chemistry ; Antifungal Agents - pharmacology ; Antioxidants - chemistry ; Antioxidants - pharmacology ; Ascomycota - chemistry ; Ascomycota - metabolism ; bioactivities ; Cholinesterase Inhibitors - chemistry ; Cholinesterase Inhibitors - pharmacology ; Cytochalasins - chemistry ; Cytochalasins - pharmacology ; Drug Evaluation, Preclinical - methods ; Endophytes - metabolism ; endophytic fungi ; Humans ; Lactones ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Mycotoxins - chemistry ; Mycotoxins - metabolism ; Neutrophils - drug effects ; Neutrophils - metabolism ; Phomopsis sp ; Reactive Oxygen Species - metabolism ; Secondary Metabolism ; secondary metabolites ; Senna Plant - microbiology ; Senna spectabilis ; Sesquiterpenes - chemistry ; Sesquiterpenes - pharmacology
É parte de: Molecules (Basel, Switzerland), 2014-05, Vol.19 (5), p.6597-6608
Descrição: Chemical investigation of an acetonitrile fraction from the endophytic fungus Phomopsis sp. led to the isolation of the new natural product 2-hydroxy-alternariol (7) together with the known compounds cytochalasins J (1) and H (2), 5'-epialtenuene (3) and the mycotoxins alternariol monomethyl ether (AME, 4), alternariol (AOH, 5) and cytosporone C (6). The structure of the new compound was elucidated by using 1-D and 2-D NMR (nuclear magnetic resonance) and high resolution mass spectrometry. The cytochalasins J (1) and H (2) and AOH (5) exhibited potent inhibition of the total ROS (reactive oxygen species) produced by stimulated human neutrophils and acted as potent potential anti-inflammatory agents. Moreover, cytochalasin H (2) demonstrated antifungal and acetylcholinesterase enzyme (AChE) inhibition in vitro.
Editor: Switzerland: MDPI
Idioma: Inglês

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Bioactive secondary metabolites from Phomopsis sp., an endophytic fungus from Senna spectabilis

Chapla, Vanessa Mara ; Zeraik, Maria Luiza ; Ximenes, Valdecir F ; Zanardi, Lisinéia Maria ; Lopes, Márcia N ; Cavalheiro, Alberto José ; Silva, Dulce Helena S ; Young, Maria Cláudia M ; Fonseca, Luiz Marcos da ; Bolzani, Vanderlan S ; Araújo, Angela Regina

Switzerland: MDPI

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