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Multifunctional System Polyaniline-Decorated ZIF‑8 Nanoparticles as a New Chemo-Photothermal Platform for Cancer Therapy

Silva, Janine S. F ; Silva, José Y. R ; de Sá, Gilberto F ; Araújo, Silvany S ; Filho, Manoel A. Gomes ; Ronconi, Célia M ; Santos, Thiago C ; Júnior, Severino A

ACS omega, 2018-09, Vol.3 (9), p.12147-12157 [Periódico revisado por pares]

United States: American Chemical Society

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  • Título:
    Multifunctional System Polyaniline-Decorated ZIF‑8 Nanoparticles as a New Chemo-Photothermal Platform for Cancer Therapy
  • Autor: Silva, Janine S. F ; Silva, José Y. R ; de Sá, Gilberto F ; Araújo, Silvany S ; Filho, Manoel A. Gomes ; Ronconi, Célia M ; Santos, Thiago C ; Júnior, Severino A
  • É parte de: ACS omega, 2018-09, Vol.3 (9), p.12147-12157
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
  • Descrição: Polyaniline-decorated ZIF-8 nanoparticles (nPANI@nZIF-8) were easily synthesized and employed as a multifunctional system for the delivery of the antitumor drug 5-fluorouracil (5-FU). Because of the storage ability of the network ZIF-8, 68% of the total amount of the 5-FU drug was released at pH 5.2. The system exhibits absorption in the near-infrared (NIR) region and can be used in the photothermal therapy owing to the presence of nPANI, which has a strong NIR uptake. This absorption causes local hyperthermia by aiding in the diffusion of the drug molecules contained by the polymer into nPANI@nZIF-8/5-FU achieving a greater release of the 5-FU drug, about 80% activated by an NIR laser (λ = 980 nm). This hyperthermia reached about 70 °C (200 μL, 1 mg mL–1 nPANI@nZIF-8), which was directly proportional to the concentration of the material. Therefore, our work can aid in the construction of new chemo-photothermal platforms that may be employed in cancer therapy.
  • Editor: United States: American Chemical Society
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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