skip to main content
Idioma:
Primo Search
Clear Search Box
Search in: Busca Geral
Busca Avançada
Busca por Índices

Association between the Fatty Liver Index and Risk of Type 2 Diabetes in the EPIC-Potsdam Study

Jäger, Susanne ; Jacobs, Simone ; Kröger, Janine ; Stefan, Norbert ; Fritsche, Andreas ; Weikert, Cornelia ; Boeing, Heiner ; Schulze, Matthias B

PloS one, 2015-04, Vol.10 (4), p.e0124749-e0124749 [Periódico revisado por pares]

United States: Public Library of Science

Texto completo disponível

Citações Citado por
  • Título:
    Association between the Fatty Liver Index and Risk of Type 2 Diabetes in the EPIC-Potsdam Study
  • Autor: Jäger, Susanne ; Jacobs, Simone ; Kröger, Janine ; Stefan, Norbert ; Fritsche, Andreas ; Weikert, Cornelia ; Boeing, Heiner ; Schulze, Matthias B
  • Assuntos: Alcohol use ; Attenuation ; Body mass ; Body mass index ; Cancer ; Confidence Intervals ; Decomposition ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - etiology ; Epidemiology ; Fatty liver ; Fatty Liver - complications ; Female ; Germany ; Health risks ; Humans ; Liver ; Male ; Middle Aged ; Nutrition ; Prospective Studies ; Risk analysis ; Risk Factors ; Statistical analysis ; Triglycerides ; Type 2 diabetes
  • É parte de: PloS one, 2015-04, Vol.10 (4), p.e0124749-e0124749
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Competing Interests: The authors have declared that no competing interests exist.
    Conceived and designed the experiments: HB MBS. Analyzed the data: S. Jäger. Wrote the paper: S. Jäger. Acquisition of the data: AF HB. Interpretation of the data: S. Jäger S. Jacobs JK NS CW MBS. Critical revision of the manuscript: S. Jacobs JK NS AF CW HB MBS. Supervision of the study: HB MBS. Obtained funding: HB MBS. Approval of the final version of the manuscript: S. Jäger S. Jacobs JK NS AF CW HB MBS.
  • Descrição: The fatty liver index (FLI) predicts fatty liver by using BMI, waist circumference, γ-glutamyltransferase and triglycerides. We investigated the association between the FLI and the risk of type 2 diabetes and evaluated to what extent single FLI components contribute to the diabetes risk. We analysed a case-cohort study (random sub-cohort: 1922; incident cases: 563) nested within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study. The proportion of exposure effect (PEE) explained by single FLI components was evaluated and effect decomposition using inverse probability weighting (IPW) was applied. Women and men with a FLI ≥ 60 compared to those with a FLI < 30 had a multivariable-adjusted Hazard Ratio (HR) of 17.6; 95% confidence interval (CI) 11.1-28.0 and HR: 10.9; 95% CI 6.22-19.2, respectively. Adjustment for BMI or waist circumference attenuated this association in men [PEE BMI (95% CI) = 53.8% (43.9%-65.8%); PEE waist (95% CI) = 54.8% (44.2%-68.8%)]. In women, adjustment for waist circumference attenuated the association to a lesser degree than in men [PEE waist (95% CI) = 31.1%; (21.9%-43.1%)] while BMI had no appreciable effect [PEE BMI (95% CI) = 11.0% (2.68%-21.0%)]. γ-glutamyltransferase and triglycerides showed only a small attenuation in women [PEE GGT(95% CI) = 3.11% (-0.72%-4.48%); PEE TG (95% CI) = 6.36% (3.81%-9.92%)] and in men [PEE GGT = 0%; PEE TG (95% CI) = 6.23% (2.03%-11.8%)]. In women, the total effect was decomposed into a direct effect and 4 indirect effects (HR BMI = 1.10; HR waist = 1.28; HR GGT = 0.97 and HR TG = 1.03). In men, the 4 indirect effects were HR BMI = 1.25; HR waist = 1.29; HR GGT = 0.97 and HR TG = 0.99. These data suggest that the FLI, as a proxy for fatty liver, is associated with risk of type 2 diabetes. This association is only partly explained by standard estimates of overall and abdominal body fatness, particularly among women.
  • Editor: United States: Public Library of Science
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.

  • Buscando por
  • emscope:(ASSIN_USP),scope:(USP),scope:(PRUSP),scope:(EBOOKS),scope:(PRODUCAO),scope:(EREVISTAS),scope:(DEDALUS),scope:(CR-USP),scope:(PRODINTEL),scope:(BDPI),primo_central_multiple_fe
  • Mostrar o que foi encontrado até o momento