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Euterpe oleracea Mart.-Derived Polyphenols Protect Mice from Diet-Induced Obesity and Fatty Liver by Regulating Hepatic Lipogenesis and Cholesterol Excretion

de Oliveira, Paola Raquel B ; da Costa, Cristiane A ; de Bem, Graziele F ; Cordeiro, Viviane S C ; Santos, Izabelle B ; de Carvalho, Lenize C R M ; da Conceição, Ellen Paula S ; Lisboa, Patrícia Cristina ; Ognibene, Dayane T ; Sousa, Pergentino José C ; Martins, Gabriel R ; da Silva, Antônio Jorge R ; de Moura, Roberto S ; Resende, Angela C Guillou, Hervé

PloS one, 2015-12, Vol.10 (12), p.e0143721-e0143721 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Euterpe oleracea Mart.-Derived Polyphenols Protect Mice from Diet-Induced Obesity and Fatty Liver by Regulating Hepatic Lipogenesis and Cholesterol Excretion
Autor: de Oliveira, Paola Raquel B ; da Costa, Cristiane A ; de Bem, Graziele F ; Cordeiro, Viviane S C ; Santos, Izabelle B ; de Carvalho, Lenize C R M ; da Conceição, Ellen Paula S ; Lisboa, Patrícia Cristina ; Ognibene, Dayane T ; Sousa, Pergentino José C ; Martins, Gabriel R ; da Silva, Antônio Jorge R ; de Moura, Roberto S ; Resende, Angela C
Guillou, Hervé
Assuntos: Adipokines - metabolism ; Adipose tissue ; Adipose Tissue - drug effects ; Adipose Tissue - pathology ; Animals ; Antioxidants ; Antioxidants - metabolism ; Apoptosis ; Berries ; Biology ; Body fat ; Body weight ; Body Weight - drug effects ; Body weight gain ; Carbonyls ; Care and treatment ; Cholesterol ; Cholesterol - biosynthesis ; Cholesterol - metabolism ; Complications and side effects ; Development and progression ; Diet ; Diet, High-Fat - adverse effects ; Eating - drug effects ; Enzymes ; Euterpe - chemistry ; Euterpe oleracea ; Excretion ; Fatty acids ; Fatty Acids - biosynthesis ; Fatty liver ; Food intake ; Gene expression ; Gene Expression Regulation - drug effects ; Glucose ; Hydroxymethylglutaryl-CoA reductase ; Hypertension ; Insulin resistance ; Kinases ; Lipid metabolism ; Lipids ; Lipogenesis ; Lipogenesis - drug effects ; Liver ; Liver - drug effects ; Liver - metabolism ; Liver - pathology ; Liver diseases ; Male ; Malondialdehyde ; Metabolic syndrome ; Metabolism ; Mice ; Mice, Inbred C57BL ; Non-alcoholic Fatty Liver Disease - etiology ; Non-alcoholic Fatty Liver Disease - metabolism ; Non-alcoholic Fatty Liver Disease - pathology ; Non-alcoholic Fatty Liver Disease - prevention & control ; Obesity ; Obesity - etiology ; Obesity - metabolism ; Obesity - pathology ; Obesity - prevention & control ; Organ Size - drug effects ; Oxidative metabolism ; Oxidative stress ; Oxidative Stress - drug effects ; Pathogenesis ; Patient outcomes ; Pharmacology ; Physiology ; Polyphenols ; Polyphenols - pharmacology ; Proteins ; Restoration ; Rodents ; Seeds - chemistry ; Steatosis ; Sterol regulatory element-binding protein ; Weight reduction
É parte de: PloS one, 2015-12, Vol.10 (12), p.e0143721-e0143721
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Competing Interests: The authors have the following interests: they declare that Roberto Soares de Moura is the inventor of the following patent applications: 1) Process to obtain decoctions of skins and stone of the fruit of Euterpe oleracea (Açai), process to obtain a hydro-alcoholic extract from the decoctions, process to obtain a lyophilized and/or spray dried from the hydro-alcoholic extracts; process to obtain pharmaceutical preparations containing the lyophilized and/or spay dried, and therapeutic indications of the preparations as vasodilators and on the prevention and treatment of vasospastic ischemical syndromes and arterial hypertension (PCT/BR2007/000178). The other authors have declared that no competing interests exist. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.
Conceived and designed the experiments: ACR RSM PCL DTO AJRS. Performed the experiments: PRBO CAC GFB VSCC IBS LCRMC EPSC GRM PJCS. Analyzed the data: PRBO CAC GFB EPSC GRM AJRS ACR RSM PCL DTO. Contributed reagents/materials/analysis tools: ACR RSM PCL AJRS. Wrote the paper: PRBO CAC ACR RSM AJRS PCL.
Descrição: The aim of this study was to investigate the effect of a polyphenol-rich Açaí seed extract (ASE, 300 mg/kg-1d-1) on adiposity and hepatic steatosis in mice that were fed a high-fat (HF) diet and its underlying mechanisms based on hepatic lipid metabolism and oxidative stress. Four groups were studied: C57BL/6 mice that were fed with standard diet (10% fat, Control), 10% fat + ASE (ASE), 60% fat (HF), and 60% fat + ASE (HF + ASE) for 12 weeks. We evaluated the food intake, body weight gain, serum glucose and lipid profile, hepatic cholesterol and triacyglycerol (TG), hepatic expression of pAMPK, lipogenic proteins (SREBP-1c, pACC, ACC, HMG-CoA reductase) and cholesterol excretion transporters, ABCG5 and ABCG8. We also evaluated the steatosis in liver sections and oxidative stress. ASE reduced body weight gain, food intake, glucose levels, accumulation of cholesterol and TG in the liver, which was associated with a reduction of hepatic steatosis. The increased expressions of SREBP-1c and HMG-CoA reductase and reduced expressions of pAMPK and pACC/ACC in HF group were antagonized by ASE. The ABCG5 and ABCG8 transporters expressions were increased by the extract. The antioxidant effect of ASE was demonstrated in liver of HF mice by restoration of SOD, CAT and GPx activities and reduction of the increased levels of malondialdehyde and protein carbonylation. In conclusion, ASE substantially reduced the obesity and hepatic steatosis induced by HF diet by reducing lipogenesis, increasing cholesterol excretion and improving oxidative stress in the liver, providing a nutritional resource for prevention of obesity-related adiposity and hepatic steatosis.
Editor: United States: Public Library of Science
Idioma: Inglês

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Euterpe oleracea Mart.-Derived Polyphenols Protect Mice from Diet-Induced Obesity and Fatty Liver by Regulating Hepatic Lipogenesis and Cholesterol Excretion

United States: Public Library of Science

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