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Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies

Del Gobbo, Liana C ; Imamura, Fumiaki ; Wu, Jason HY ; de Oliveira Otto, Marcia C ; Chiuve, Stephanie E ; Mozaffarian, Dariush

The American journal of clinical nutrition, 2013-07, Vol.98 (1), p.160-173 [Periódico revisado por pares]

Bethesda, MD: American Society for Clinical Nutrition

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Título:
Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies
Autor: Del Gobbo, Liana C ; Imamura, Fumiaki ; Wu, Jason HY ; de Oliveira Otto, Marcia C ; Chiuve, Stephanie E ; Mozaffarian, Dariush
Assuntos: Biological and medical sciences ; Cardiac arrhythmia ; Cardiovascular disease ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - prevention & control ; clinical nutrition ; clinical trials ; Databases, Factual ; Diet ; dietary restriction ; Dietary Supplements ; dose response ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; Humans ; hypomagnesemia ; Magnesium ; Magnesium - blood ; Meta-analysis ; myocardial ischemia ; prospective studies ; Randomized Controlled Trials as Topic ; risk ; Risk assessment ; Risk Factors ; systematic review ; Vertebrates: anatomy and physiology, studies on body, several organs or systems
É parte de: The American journal of clinical nutrition, 2013-07, Vol.98 (1), p.160-173
Notas: http://dx.doi.org/10.3945/ajcn.112.053132
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-3
ObjectType-Review-2
ObjectType-Undefined-4
Descrição: Background: Clinical hypomagnesemia and experimental restriction of dietary magnesium increase cardiac arrhythmias. However, whether or not circulating or dietary magnesium at usual concentrations or intakes influences the risk of cardiovascular disease (CVD), including fatal ischemic heart disease (IHD), is unclear.Objective: We performed a systematic review and meta-analysis to investigate prospective associations of circulating and dietary magnesium with incidence of CVD, IHD, and fatal IHD.Design: Multiple literature databases were systematically searched without language restriction through May 2012. Inclusion decisions and data extraction were performed in duplicate. Linear dose-response associations were assessed by using random-effects meta-regression. Potential nonlinear associations were evaluated by using restricted cubic splines.Results: Of 2303 articles, 16 studies met the eligibility criteria; these studies comprised 313,041 individuals and 11,995 CVD, 7534 IHD, and 2686 fatal IHD events. Circulating magnesium (per 0.2 mmol/L increment) was associated with a 30% lower risk of CVD (RR: 0.70; 95% CI: 0.56, 0.88 per 0.2 mmol/L) and trends toward lower risks of IHD (RR: 0.83; 95% CI: 0.75, 1.05) and fatal IHD (RR: 0.61; 95% CI: 0.37, 1.00). Dietary magnesium (per 200-mg/d increment) was not significantly associated with CVD (RR: 0.89; 95% CI: 0.75, 1.05) but was associated with a 22% lower risk of IHD (RR: 0.78; 95% CI: 0.67, 0.92). The association of dietary magnesium with fatal IHD was nonlinear (P < 0.001), with an inverse association observed up to a threshold of ∼250 mg/d (RR: 0.73; 95% CI: 0.62, 0.86), compared with lower intakes.Conclusion: Circulating and dietary magnesium are inversely associated with CVD risk, which supports the need for clinical trials to evaluate the potential role of magnesium in the prevention of CVD and IHD.
Editor: Bethesda, MD: American Society for Clinical Nutrition
Idioma: Inglês

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Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies

Del Gobbo, Liana C ; Imamura, Fumiaki ; Wu, Jason HY ; de Oliveira Otto, Marcia C ; Chiuve, Stephanie E ; Mozaffarian, Dariush

Bethesda, MD: American Society for Clinical Nutrition

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