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Androgen deprivation of prostate cancer: Leading to a therapeutic dead end

Katzenwadel, Arndt ; Wolf, Philipp

Cancer letters, 2015-10, Vol.367 (1), p.12-17 [Periódico revisado por pares]

Ireland: Elsevier Ireland Ltd

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Título:
Androgen deprivation of prostate cancer: Leading to a therapeutic dead end
Autor: Katzenwadel, Arndt ; Wolf, Philipp
Assuntos: Androgen Antagonists - adverse effects ; Androgen Antagonists - therapeutic use ; Androgen deprivation therapy ; Androgens ; Animals ; Antineoplastic Agents, Hormonal - adverse effects ; Antineoplastic Agents, Hormonal - therapeutic use ; Cancer therapies ; Castration resistance ; Chemotherapy ; Diabetes ; Disease Progression ; Drug Design ; Drug Resistance, Neoplasm ; Drugs ; Gene expression ; Hematology, Oncology and Palliative Medicine ; Humans ; Ligands ; Male ; Metastasis ; Molecular alterations ; Molecular Targeted Therapy ; Mortality ; Neoplasm Recurrence, Local ; Patients ; Prostate cancer ; Prostatic Neoplasms, Castration-Resistant - drug therapy ; Prostatic Neoplasms, Castration-Resistant - metabolism ; Prostatic Neoplasms, Castration-Resistant - mortality ; Prostatic Neoplasms, Castration-Resistant - pathology ; Proteins ; Regulatory approval ; Signal Transduction - drug effects ; Studies ; Testosterone ; Treatment Outcome ; Tumors
É parte de: Cancer letters, 2015-10, Vol.367 (1), p.12-17
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Highlights • Androgen deprivation therapy (ADT) leads to numerous molecular alterations in prostate cancer. • ADT promotes more aggressive behavior and metastasis of tumor cells. • ADT ends in incurable castration resistant disease. • ADT of advanced prostate cancer leads to a reduced efficacy of anticancer agents. • Therapeutic intervention seems to be indicated before castration resistance occurs.
Editor: Ireland: Elsevier Ireland Ltd
Idioma: Inglês

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Androgen deprivation of prostate cancer: Leading to a therapeutic dead end

Katzenwadel, Arndt ; Wolf, Philipp

Ireland: Elsevier Ireland Ltd

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