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New Insights into the Origin of the HIV Type 1 Subtype A Epidemic in Former Soviet Union's Countries Derived from Sequence Analyses of Preepidemically Transmitted Viruses

THOMSON, Michael M ; VAZQUEZ DE PARGA, Elena ; VEGA, Yolanda ; PEREZ-ALVAREZ, Lucia ; CONTRERAS, Gerardo ; MEDRANO, Leandro ; OSMANOV, Saladin ; NAJERA, Rafael ; VINOGRADOVA, Anna ; SIERRA, Maria ; YAKOVLEV, Aleksey ; RAKHMANOVA, Aza ; DELGADO, Elena ; CASADO, Gema ; MUNOZ, Mercedes ; CARMONA, Rocio

AIDS research and human retroviruses, 2007-12, Vol.23 (12), p.1599-1604 [Periódico revisado por pares]

Larchmont, NY: Liebert

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New Insights into the Origin of the HIV Type 1 Subtype A Epidemic in Former Soviet Union's Countries Derived from Sequence Analyses of Preepidemically Transmitted Viruses
Autor: THOMSON, Michael M ; VAZQUEZ DE PARGA, Elena ; VEGA, Yolanda ; PEREZ-ALVAREZ, Lucia ; CONTRERAS, Gerardo ; MEDRANO, Leandro ; OSMANOV, Saladin ; NAJERA, Rafael ; VINOGRADOVA, Anna ; SIERRA, Maria ; YAKOVLEV, Aleksey ; RAKHMANOVA, Aza ; DELGADO, Elena ; CASADO, Gema ; MUNOZ, Mercedes ; CARMONA, Rocio
Assuntos: Base Sequence ; Democratic Republic of the Congo - epidemiology ; Diagnosis ; DNA sequencing ; Genetic aspects ; Genome, Viral ; Health aspects ; HIV (Viruses) ; HIV infection ; HIV Infections - epidemiology ; HIV Infections - transmission ; HIV Infections - virology ; HIV-1 - classification ; HIV-1 - genetics ; Human immunodeficiency virus 1 ; Humans ; Molecular Epidemiology ; Molecular Sequence Data ; Nucleotide sequencing ; Phylogeny ; Risk factors ; Russia - epidemiology ; Substance Abuse, Intravenous - virology ; Ukraine - epidemiology
É parte de: AIDS research and human retroviruses, 2007-12, Vol.23 (12), p.1599-1604
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: The HIV-1 subtype A epidemic affecting injecting drug users (IDU) in former Soviet Union (FSU) countries started dramatically in Odessa, southern Ukraine, in 1995, and is caused by a variant of monophyletic origin, often designated IDU-A. We phylogenetically analyzed one near full-length genome and two partial sequences of three HIV-1 subtype A viruses collected in St. Petersburg, Russia, heterosexually transmitted in 1992-1994. The sequences branched basally to the IDU-A clade, together with eight viruses from Odessa collected in 1993, all presumably acquired heterosexually, and two viruses from the Democratic Republic of Congo. Of all other FSU sequences in databases, only those from three recently collected viruses, one from Ukraine and two from northwestern Russia, at least one of them acquired heterosexually, branched basally to the IDU-A cluster. The results indicate that the FSU IDU-A variant derives from a strain that initially propagated heterosexually in Ukraine and originated in central Africa.
Editor: Larchmont, NY: Liebert
Idioma: Russo;Inglês

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New Insights into the Origin of the HIV Type 1 Subtype A Epidemic in Former Soviet Union's Countries Derived from Sequence Analyses of Preepidemically Transmitted Viruses

Larchmont, NY: Liebert

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