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Flavipesides A–C, PKS-NRPS Hybrids as Pancreatic Lipase Inhibitors from a Marine Sponge Symbiotic Fungus Aspergillus flavipes 164013

Jiao, Wei-Hua ; Xu, Qi-Hang ; Ge, Guang-Bo ; Shang, Ru-Yi ; Zhu, Hong-Rui ; Liu, Hong-Yan ; Cui, Jie ; Sun, Fan ; Lin, Hou-Wen

Organic letters, 2020-03, Vol.22 (5), p.1825-1829 [Periódico revisado por pares]

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Flavipesides A–C, PKS-NRPS Hybrids as Pancreatic Lipase Inhibitors from a Marine Sponge Symbiotic Fungus Aspergillus flavipes 164013
Autor: Jiao, Wei-Hua ; Xu, Qi-Hang ; Ge, Guang-Bo ; Shang, Ru-Yi ; Zhu, Hong-Rui ; Liu, Hong-Yan ; Cui, Jie ; Sun, Fan ; Lin, Hou-Wen
Assuntos: 4-Butyrolactone - analogs & derivatives ; 4-Butyrolactone - chemistry ; 4-Butyrolactone - isolation & purification ; 4-Butyrolactone - pharmacology ; Animals ; Aspergillus - chemistry ; Crystallography, X-Ray ; Enzyme Inhibitors - chemistry ; Enzyme Inhibitors - isolation & purification ; Enzyme Inhibitors - pharmacology ; Fungi - chemistry ; Fungi - metabolism ; Lipase - chemistry ; Lipase - metabolism ; Molecular Structure ; Porifera - chemistry ; Spectrum Analysis
É parte de: Organic letters, 2020-03, Vol.22 (5), p.1825-1829
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Three unusual chlorinated PKS-NRPS hybrid metabolites, flavipesides A–C (1–3), were isolated from a strain of marine sponge symbiotic fungus Aspergillus flavipes 164013. Their structures were determined by spectroscopic data analysis, and absolute configurations were assigned by single-crystal X-ray diffraction with ECD spectral analysis. Flavipesides A–C showed potent pancreatic lipase (PL) inhibitory activity with IC50 values of 0.07–0.23 μM.
Editor: United States: American Chemical Society
Idioma: Inglês

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