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Delayed voluntary physical exercise restores “when” and “where” object recognition memory after traumatic brain injury

Martínez-Drudis, Laura ; Amorós-Aguilar, Laura ; Torras-Garcia, Meritxell ; Serra-Elias, Bruna ; Costa-Miserachs, David ; Portell-Cortés, Isabel ; Coll-Andreu, Margalida

Behavioural brain research, 2021-02, Vol.400, p.113048-113048, Article 113048 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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Título:
Delayed voluntary physical exercise restores “when” and “where” object recognition memory after traumatic brain injury
Autor: Martínez-Drudis, Laura ; Amorós-Aguilar, Laura ; Torras-Garcia, Meritxell ; Serra-Elias, Bruna ; Costa-Miserachs, David ; Portell-Cortés, Isabel ; Coll-Andreu, Margalida
Assuntos: Animals ; Brain Injuries, Traumatic - complications ; Brain Injuries, Traumatic - physiopathology ; Brain Injuries, Traumatic - rehabilitation ; Brain-Derived Neurotrophic Factor - metabolism ; Cytokines ; Cytokines - metabolism ; Disease Models, Animal ; Exercise Therapy ; Hippocampus - immunology ; Hippocampus - metabolism ; Male ; Memory Disorders - etiology ; Memory Disorders - physiopathology ; Memory Disorders - rehabilitation ; Memory, Episodic ; Neurotrophins ; Object location memory ; Physical Conditioning, Animal - physiology ; Physical exercise ; Rats ; Rats, Sprague-Dawley ; Recognition, Psychology - physiology ; Spatial Memory - physiology ; Temporal order memory ; Traumatic brain injury
É parte de: Behavioural brain research, 2021-02, Vol.400, p.113048-113048, Article 113048
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: •Traumatic brain injury impaired the “when” (temporal order) and “where” (object location) components of episodic-like memory.•Voluntary physical exercise initiated 11 days after injury reversed “when” and “where” memory deficits after TBI.•Enhanced hippocampal BDNF, related to physical exercise treatment, was involved in memory recovery. Physical exercise has been associated with improved cognition and may even reduce memory deficits after brain injuries. The aims of this work were to: 1) assess whether voluntary physical exercise can reduce the deficits associated with traumatic brain injury (TBI) in two different components of episodic-like memory based on object recognition, temporal order memory (“when”), and object location memory (“where”); and 2) determine whether changes in levels of brain-derived neurotrophic factor (BDNF) in the hippocampus and prefrontal cortex, as well as alterations in hippocampal cytokines, insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF), may influence the effects exercise has on either or both tasks. The rats were distributed into a sham group, a TBI group that remained sedentary (TBI-sed), and a TBI group that had access to a running wheel for a 25-day period from post-injury day 11 (TBI-exe). The rats were sacrificed after the “where” memory task, at post-injury day 37. Physical exercise restored the “when” and “where” memories, which had been impaired by the TBI, and increased the concentration of BDNF in the hippocampus, but not the prefrontal cortex. Neither TBI nor exercise were found to significantly affect hippocampal cytokines, IGF-1 or VEGF at this time post-injury. BDNF levels showed significant positive correlations with exercise, and with “when” (but not “where”) memory. These results indicate that post-injury physical exercise restores “when” and “where” object recognition memory tasks after TBI, and that increased BDNF seems to be involved in this effect, particularly with regard to “when” memory.
Editor: Netherlands: Elsevier B.V
Idioma: Inglês

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Delayed voluntary physical exercise restores “when” and “where” object recognition memory after traumatic brain injury

Martínez-Drudis, Laura ; Amorós-Aguilar, Laura ; Torras-Garcia, Meritxell ; Serra-Elias, Bruna ; Costa-Miserachs, David ; Portell-Cortés, Isabel ; Coll-Andreu, Margalida

Netherlands: Elsevier B.V

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