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Troponin T cardiac analysis: clinical cases of the limits of its cardiospecificity

Coirier, Valentin ; Pelletier, Romain ; Sébillot, Martine ; Lefèvre, Charles R ; Peltier, Lucas ; Collet, Nicolas ; Bendavid, Claude ; Jégo, Patrick ; Moreau, Caroline

Annales de biologie clinique (Paris), 2021-04, Vol.79 (2), p.176-180 [Periódico revisado por pares]

France

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  • Título:
    Troponin T cardiac analysis: clinical cases of the limits of its cardiospecificity
  • Autor: Coirier, Valentin ; Pelletier, Romain ; Sébillot, Martine ; Lefèvre, Charles R ; Peltier, Lucas ; Collet, Nicolas ; Bendavid, Claude ; Jégo, Patrick ; Moreau, Caroline
  • Assuntos: Biomarkers ; Creatine Kinase ; Humans ; Myocardium ; Troponin I ; Troponin T
  • É parte de: Annales de biologie clinique (Paris), 2021-04, Vol.79 (2), p.176-180
  • Notas: ObjectType-Case Study-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-4
    content type line 23
    ObjectType-Report-1
    ObjectType-Article-3
  • Descrição: Myositis are systemic diseases, in which heart damage is possible. Cardiac troponin T is often found to be defective to detect cardiac involvement. We report cases of two patients with a myositis. Diagnosis was retained based on muscle pain, increase in serum creatinine kinase, and inflammatory muscle damage on MRI. Histology confirmed the diagnosis for one of the two patients. Cardiac troponin T was measured in both patients, to detect myocardial involvement. Despite a serum elevation of this marker, cardiological assessment remained negative (electrocardiogram, cardiac ultrasound, cardiac MRI). Cardiac troponin I was normal in serum because of the absence of correlation with peripheral muscle involvement. Cardiac troponin T is correlated with muscle involvement in patients with myositis. Cardiac troponin I should be preferred because of a better specificity.
  • Editor: France
  • Idioma: Francês;Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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