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Early graft patency after off-pump and on-pump coronary bypass surgery: a prospective randomized study

Sousa Uva, Miguel ; Cavaco, Sara ; Oliveira, António G. ; Matias, Fernando ; Silva, Catarina ; Mesquita, Armindo ; Aguiar, Pedro ; Bau, José ; Pedro, Albino ; Magalhães, Manuel Pedro

European heart journal, 2010-10, Vol.31 (20), p.2492-2499 [Periódico revisado por pares]

Oxford: Oxford University Press

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Título:
Early graft patency after off-pump and on-pump coronary bypass surgery: a prospective randomized study
Autor: Sousa Uva, Miguel ; Cavaco, Sara ; Oliveira, António G. ; Matias, Fernando ; Silva, Catarina ; Mesquita, Armindo ; Aguiar, Pedro ; Bau, José ; Pedro, Albino ; Magalhães, Manuel Pedro
Assuntos: Adult ; Aged ; Aged, 80 and over ; Anticoagulants - administration & dosage ; Biological and medical sciences ; Cardiology. Vascular system ; Cardiopulmonary bypass ; Coronary Artery Bypass - methods ; Coronary artery bypass grafting ; Coronary Artery Bypass, Off-Pump - methods ; Coronary Artery Disease - surgery ; Coronary heart disease ; Female ; Graft Survival ; Heart ; Heparin - administration & dosage ; Humans ; Male ; Medical sciences ; Mental Disorders - etiology ; Middle Aged ; Myocardial revascularization ; Nervous System Diseases - etiology ; Neuropsychological Tests ; Off-pump ; Postoperative Complications - etiology ; Prospective Studies ; Quality of Life ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the heart ; Treatment Outcome ; Vascular Patency
É parte de: European heart journal, 2010-10, Vol.31 (20), p.2492-2499
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Descrição: Aims Uncertainty persists regarding the impact of the off-pump technique on coronary bypass graft patency. The primary objective of this study was to assess coronary artery bypass graft patency in patients randomized to off-pump and on-pump multivessel coronary artery bypass grafting (CABG). Secondary objectives were clinical outcomes and neuropsychological functioning. Methods and results One hundred and fifty patients were randomized to off-pump (n = 75) or on-pump CABG (n = 75). Graft patency was assessed by multidetector computed tomography 5 weeks after surgery. The two groups were similar regarding patients' characteristics and logistic Euroscore (3.6 vs. 3.7%). Mean number of grafts performed was 3.5 ± 0.6 and 3.5 ± 0.6 in off-pump and on-pump, respectively (P = 0.7). Raw graft patency rate was 89.9% in off-pump and 95.0% in on-pump (OR 2.2, 95% CI 1.07–4.44; P = 0.03). Nineteen (27%) off-pump and 9 (13%) on-pump patients had at least one occluded graft (P = 0.04) and the proportion of patent grafts per patient was 0.91 ± 0.2 in off-pump vs. 0.96 ± 0.1 in on-pump (P = 0.06). However, after adjusting by heparin dose, graft patency was not statistically different between groups (OR 0.87, 95% CI 0.25–2.98, P = 0.83). At 30 days, there was no statistically significant difference in major adverse events and neuropsychological functioning between off-pump and on-pump groups. One-year follow-up showed similar functional class and positive treadmill exercise tests. Conclusions Under the conditions this trial was conducted, CABG performed off-pump had lower overall graft patency rate than on-pump, which was not statistically different after controlling for total heparin dose. Thirty-day complications, neuropsychological functioning, and one-year clinical and functional outcomes were not statistically different between the two techniques.
Editor: Oxford: Oxford University Press
Idioma: Inglês

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Early graft patency after off-pump and on-pump coronary bypass surgery: a prospective randomized study

Sousa Uva, Miguel ; Cavaco, Sara ; Oliveira, António G. ; Matias, Fernando ; Silva, Catarina ; Mesquita, Armindo ; Aguiar, Pedro ; Bau, José ; Pedro, Albino ; Magalhães, Manuel Pedro

Oxford: Oxford University Press

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