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Hepatic steatosis in hepatitis B virus infected patients: Meta-analysis of risk factors and comparison with hepatitis C infected patients

Machado, Mariana V ; Oliveira, António G ; Cortez-Pinto, Helena

Journal of gastroenterology and hepatology, 2011-09, Vol.26 (9), p.1361-1367 [Periódico revisado por pares]

Melbourne, Australia: Blackwell Publishing Asia

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Título:
Hepatic steatosis in hepatitis B virus infected patients: Meta-analysis of risk factors and comparison with hepatitis C infected patients
Autor: Machado, Mariana V ; Oliveira, António G ; Cortez-Pinto, Helena
Assuntos: Adult ; Biological and medical sciences ; Body mass index ; Cholesterol ; Diabetes mellitus ; Ethanol ; Fatty liver ; Fatty Liver - epidemiology ; Fatty Liver - virology ; Female ; Fibrosis ; Gastroenterology. Liver. Pancreas. Abdomen ; Genotypes ; hepatitis B ; hepatitis B e antigen ; Hepatitis B virus ; Hepatitis B, Chronic - complications ; Hepatitis B, Chronic - diagnosis ; Hepatitis B, Chronic - epidemiology ; Hepatitis C ; Hepatitis C virus ; Hepatitis C, Chronic - complications ; Hepatitis C, Chronic - diagnosis ; Hepatitis C, Chronic - epidemiology ; Human viral diseases ; Humans ; Infection ; Infectious diseases ; Liver ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; Obesity ; Odds Ratio ; Other diseases. Semiology ; Prevalence ; Reviews ; Risk Assessment ; Risk Factors ; steatosis ; Triglycerides ; Viral diseases ; Viral hepatitis ; Viral Load ; Young Adult
É parte de: Journal of gastroenterology and hepatology, 2011-09, Vol.26 (9), p.1361-1367
Notas: ArticleID:JGH6801
istex:11872BAF814FDA96B87A5C11C29E2E2FAD81BAF4
ark:/67375/WNG-WKBHGJS7-7
We have no conflict of interest to declare.
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
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Descrição: Background and Aims: Although hepatic steatosis (HS) has an association with hepatitis C virus (HCV) infection, an association with hepatitis B virus (HBV) is controversial. We performed a meta‐analysis to evaluate HS prevalence and risk factors, in HBV infection. Methods: Standard guidelines for performance of meta‐analyses were followed. Studies with HS assessed by histology were included. Pooled odd ratios (OR) and standardized mean differences (SMD) were obtained with the random‐effects model and DerSimonian‐Laid method. Results: Seventeen out of 21 studies were included, comprising 4100 HBV infected patients. Overall HS prevalence was 29.6%. Eight studies also included 945 HCV infected patients, showing decreased risk of HS in HBV versus HCV patients (OR 0.55, 95%CI [0.45–0.67], P < 0.001). In HBV, HS positively associated with male gender (OR 1.74, 95%CI [1.28–2.38], P < 0.001), body mass index (SMD 2.17, 95%CI [1.23, 3.11], P < 0.001), obesity (OR 6.59, 95%CI [3.51–12.257], P = 0.003), diabetes (OR 2.62, 95%CI [1.37–4.00], P = 0.004), glycemia (SMD 0.84, 95%CI [0.00, 1.67], P = 0.049), triglycerides (SMD 1.18, 95%CI [0.48, 1.89], P = 0.001), cholesterol (SMD 0.88, 95%CI [0.31, 1.45], P = 0.003), moderate alcohol consumption (OR 1.54, 95%CI [1.10–2.15], P = 0.011) and negatively with HBV DNA (SMD −74.12, 95%CI [−82.93, −65.31], P < 0.001). HS had no association with aminotransferases, HBeAg, genotype or hepatic histology, necroinflammation or fibrosis. Conclusion: HS in HBV seems to be as frequent as in the general population, and lower than in HCV infected patients, relating to metabolic factors but not with hepatic histology severity. A puzzling strong negative association between viral load and HS, may even suggest a protective effect of the virus on HS.
Editor: Melbourne, Australia: Blackwell Publishing Asia
Idioma: Inglês

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Hepatic steatosis in hepatitis B virus infected patients: Meta-analysis of risk factors and comparison with hepatitis C infected patients

Machado, Mariana V ; Oliveira, António G ; Cortez-Pinto, Helena

Melbourne, Australia: Blackwell Publishing Asia

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