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Effects of dietary Pi on the renal Na+-dependent Pi transporter NaPi-2 in thyroparathyroidectomized rats

Takahashi, F ; Morita, K ; Katai, K ; Segawa, H ; Fujioka, A ; Kouda, T ; Tatsumi, S ; Nii, T ; Taketani, Y ; Haga, H ; Hisano, S ; Fukui, Y ; Miyamoto, K I ; Takeda, E

Biochemical journal, 1998-07, Vol.333 ( Pt 1) (1), p.175-181 [Periódico revisado por pares]

England

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Título:
Effects of dietary Pi on the renal Na+-dependent Pi transporter NaPi-2 in thyroparathyroidectomized rats
Autor: Takahashi, F ; Morita, K ; Katai, K ; Segawa, H ; Fujioka, A ; Kouda, T ; Tatsumi, S ; Nii, T ; Taketani, Y ; Haga, H ; Hisano, S ; Fukui, Y ; Miyamoto, K I ; Takeda, E
Assuntos: Animals ; Biological Transport - drug effects ; Carrier Proteins - biosynthesis ; Carrier Proteins - metabolism ; Endocytosis - physiology ; Immunoblotting ; Kidney - drug effects ; Kidney - metabolism ; Kidney - ultrastructure ; Kidney Cortex - drug effects ; Kidney Cortex - metabolism ; Kidney Cortex - ultrastructure ; Male ; Microvilli - drug effects ; Microvilli - metabolism ; Nephrons - drug effects ; Nephrons - metabolism ; Parathyroid Hormone - metabolism ; Parathyroid Hormone - pharmacology ; Parathyroidectomy ; Phosphates - administration & dosage ; Phosphates - pharmacology ; Phosphorus, Dietary - administration & dosage ; Phosphorus, Dietary - pharmacology ; Rats ; Rats, Sprague-Dawley ; RNA, Messenger - biosynthesis ; Sodium-Phosphate Cotransporter Proteins ; Symporters ; Thyroidectomy
É parte de: Biochemical journal, 1998-07, Vol.333 ( Pt 1) (1), p.175-181
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Dietary Pi and parathyroid hormone (PTH) are two most important physiological and pathophysiological regulators of Pi re-absorption in the renal proximal tubule. Effects of dietary Pi on Na+/Pi co-transporter NaPi-2 were investigated in thyroparathyroidectomized (TPTX) rats. NaPi-2 protein and mRNA in the kidney cortex of TPTX rats were increased approximately 3.8- and 2.4-fold in amount respectively compared with those in the sham-operated animals. Administration of PTH to the TPTX rats resulted in a decrease in the amount of NaPi-2 protein, but not in the abundance of NaPi-2 mRNA. Deprivation of dietary Pi in the TPTX rats did not affect the amount of NaPi-2 mRNA and protein. In the Pi-deprived TPTX rats, feeding of a high-Pi diet resulted in marked decreases in Pi transport activity and the amount of NaPi-2 protein in the superficial nephrons. Immunohistochemical analysis demonstrated that administration of PTH to TPTX rats resulted in a decrease in NaPi-2 immunoreactivity from both superficial and juxtamedullary nephrons within 4 h. Switching TPTX animals from a low-Pi diet to the high-Pi diet decreased NaPi-2 immunoreactivity from superficial nephrons, but not from juxtamedullary nephrons, within 4 h. These results suggest that dietary Pi could regulate the amount of NaPi-2 protein in the superficial nephrons in a PTH-independent manner.
Editor: England
Idioma: Inglês

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Effects of dietary Pi on the renal Na+-dependent Pi transporter NaPi-2 in thyroparathyroidectomized rats

Takahashi, F ; Morita, K ; Katai, K ; Segawa, H ; Fujioka, A ; Kouda, T ; Tatsumi, S ; Nii, T ; Taketani, Y ; Haga, H ; Hisano, S ; Fukui, Y ; Miyamoto, K I ; Takeda, E

England

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