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4-Nitrobenzyloxycarbonyl Derivatives of O 6-Benzylguanine as Hypoxia-Activated Prodrug Inhibitors of O 6-Alkylguanine-DNA Alkyltransferase (AGT), Which Produces Resistance to Agents Targeting the O-6 Position of DNA Guanine
4-Nitrobenzyloxycarbonyl Derivatives of O 6-Benzylguanine as Hypoxia-Activated Prodrug Inhibitors of O 6-Alkylguanine-DNA Alkyltransferase (AGT), Which Produces Resistance to Agents Targeting the O-6 Position of DNA Guanine
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4-Nitrobenzyloxycarbonyl Derivatives of O 6-Benzylguanine as Hypoxia-Activated Prodrug Inhibitors of O 6-Alkylguanine-DNA Alkyltransferase (AGT), Which Produces Resistance to Agents Targeting the O-6 Position of DNA Guanine

Zhu, Rui ; Liu, Mao-Chin ; Luo, Mei-Zhen ; Penketh, Philip G ; Baumann, Raymond P ; Shyam, Krishnamurthy ; Sartorelli, Alan C

Journal of medicinal chemistry, 2011-11, Vol.54 (21), p.7720-7728 [Periódico revisado por pares]

American Chemical Society

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2
Hypoxia-Selective O 6‑Alkylguanine-DNA Alkyltransferase Inhibitors: Design, Synthesis, and Evaluation of 6‑(Benzyloxy)-2-(aryldiazenyl)‑9H‑purines as Prodrugs of O 6‑Benzylguanine
Hypoxia-Selective O 6‑Alkylguanine-DNA Alkyltransferase Inhibitors: Design, Synthesis, and Evaluation of 6‑(Benzyloxy)-2-(aryldiazenyl)‑9H‑purines as Prodrugs of O 6‑Benzylguanine
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Hypoxia-Selective O 6‑Alkylguanine-DNA Alkyltransferase Inhibitors: Design, Synthesis, and Evaluation of 6‑(Benzyloxy)-2-(aryldiazenyl)‑9H‑purines as Prodrugs of O 6‑Benzylguanine

Zhu, Rui ; Baumann, Raymond P ; Penketh, Philip G ; Shyam, Krishnamurthy ; Sartorelli, Alan C

Journal of medicinal chemistry, 2013-02, Vol.56 (3), p.1355-1359 [Periódico revisado por pares]

American Chemical Society

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3
4-nitrobenzyloxycarbonyl derivatives of O(6)-benzylguanine as hypoxia-activated prodrug inhibitors of O(6)-alkylguanine-DNA alkyltransferase (AGT), which produces resistance to agents targeting the O-6 position of DNA guanine
4-nitrobenzyloxycarbonyl derivatives of O(6)-benzylguanine as hypoxia-activated prodrug inhibitors of O(6)-alkylguanine-DNA alkyltransferase (AGT), which produces resistance to agents targeting the O-6 position of DNA guanine
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4-nitrobenzyloxycarbonyl derivatives of O(6)-benzylguanine as hypoxia-activated prodrug inhibitors of O(6)-alkylguanine-DNA alkyltransferase (AGT), which produces resistance to agents targeting the O-6 position of DNA guanine

Zhu, Rui ; Liu, Mao-Chin ; Luo, Mei-Zhen ; Penketh, Philip G ; Baumann, Raymond P ; Shyam, Krishnamurthy ; Sartorelli, Alan C

Journal of medicinal chemistry, 2011-11, Vol.54 (21), p.7720 [Periódico revisado por pares]

United States

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4
Antitumor Sulfonylhydrazines: Design, Structure–Activity Relationships, Resistance Mechanisms, and Strategies for Improving Therapeutic Utility
Antitumor Sulfonylhydrazines: Design, Structure–Activity Relationships, Resistance Mechanisms, and Strategies for Improving Therapeutic Utility
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Antitumor Sulfonylhydrazines: Design, Structure–Activity Relationships, Resistance Mechanisms, and Strategies for Improving Therapeutic Utility

Shyam, Krishnamurthy ; Penketh, Philip G ; Baumann, Raymond P ; Finch, Rick A ; Zhu, Rui ; Zhu, Yong-Lian ; Sartorelli, Alan C

Journal of medicinal chemistry, 2015-05, Vol.58 (9), p.3639-3671 [Periódico revisado por pares]

United States: American Chemical Society

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5
Synthesis and Biological Activity of 3- and 5-Amino Derivatives of Pyridine-2-carboxaldehyde Thiosemicarbazone
Synthesis and Biological Activity of 3- and 5-Amino Derivatives of Pyridine-2-carboxaldehyde Thiosemicarbazone
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Synthesis and Biological Activity of 3- and 5-Amino Derivatives of Pyridine-2-carboxaldehyde Thiosemicarbazone

Liu, Mao-Chin ; Lin, Tai-Shun ; Cory, Joseph G ; Cory, Ann H ; Sartorelli, Alan C

Journal of medicinal chemistry, 1996-06, Vol.39 (13), p.2586-2593 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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6
4-Nitrobenzyloxycarbonyl Derivatives of O6-Benzylguanine as Hypoxia-Activated Prodrug Inhibitors of O6-Alkylguanine-DNA Alkyltransferase (AGT) which Produces Resistance to Agents Targeting the O-6 Position of DNA Guanine
4-Nitrobenzyloxycarbonyl Derivatives of O6-Benzylguanine as Hypoxia-Activated Prodrug Inhibitors of O6-Alkylguanine-DNA Alkyltransferase (AGT) which Produces Resistance to Agents Targeting the O-6 Position of DNA Guanine
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4-Nitrobenzyloxycarbonyl Derivatives of O6-Benzylguanine as Hypoxia-Activated Prodrug Inhibitors of O6-Alkylguanine-DNA Alkyltransferase (AGT) which Produces Resistance to Agents Targeting the O-6 Position of DNA Guanine

Zhu, Rui ; Liu, Mao-Chin ; Luo, Mei-Zhen ; Penketh, Philip G. ; Baumann, Raymond P. ; Shyam, Krishnamurthy ; Sartorelli, Alan C.

Journal of medicinal chemistry, 2011-10, Vol.54 (21), p.7720-7728 [Periódico revisado por pares]

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7
SYNTHESIS AND ANTITUMOR-ACTIVITY OF AMINO DERIVATIVES OF PYRIDINE-2-CARBOXALDEHYDE THIOSEMICARBAZONE
SYNTHESIS AND ANTITUMOR-ACTIVITY OF AMINO DERIVATIVES OF PYRIDINE-2-CARBOXALDEHYDE THIOSEMICARBAZONE
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SYNTHESIS AND ANTITUMOR-ACTIVITY OF AMINO DERIVATIVES OF PYRIDINE-2-CARBOXALDEHYDE THIOSEMICARBAZONE

LIU, MC ; LIN, TS ; SARTORELLI, AC

Journal of medicinal chemistry, 1992-10, Vol.35 (20), p.3672-3677 [Periódico revisado por pares]

WASHINGTON: Amer Chemical Soc

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8
Antitumor 2-(Aminocarbonyl)-1,2-bis(methylsulfonyl)-1-(2-chloroethyl)- hydrazines
Antitumor 2-(Aminocarbonyl)-1,2-bis(methylsulfonyl)-1-(2-chloroethyl)- hydrazines
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Antitumor 2-(Aminocarbonyl)-1,2-bis(methylsulfonyl)-1-(2-chloroethyl)- hydrazines

Shyam, Krishnamurthy ; Penketh, Philip G ; Loomis, Regina H ; Rose, William C ; Sartorelli, Alan C

Journal of medicinal chemistry, 1996-02, Vol.39 (3), p.796-801 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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9
Hypoxia-selective O6-alkylguanine-DNA alkyltransferase inhibitors: design, synthesis, and evaluation of 6-(benzyloxy)-2-(aryldiazenyl)-9H-purines as prodrugs of O6-benzylguanine
Hypoxia-selective O6-alkylguanine-DNA alkyltransferase inhibitors: design, synthesis, and evaluation of 6-(benzyloxy)-2-(aryldiazenyl)-9H-purines as prodrugs of O6-benzylguanine
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Hypoxia-selective O6-alkylguanine-DNA alkyltransferase inhibitors: design, synthesis, and evaluation of 6-(benzyloxy)-2-(aryldiazenyl)-9H-purines as prodrugs of O6-benzylguanine

Zhu, Rui ; Baumann, Raymond P ; Penketh, Philip G ; Shyam, Krishnamurthy ; Sartorelli, Alan C

Journal of medicinal chemistry, 2013-02, Vol.56 (3), p.1355-1359 [Periódico revisado por pares]

United States

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10
Hypoxia-Selective Nitrobenzyloxycarbonyl Derivatives of 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)hydrazines
Hypoxia-Selective Nitrobenzyloxycarbonyl Derivatives of 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)hydrazines
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Hypoxia-Selective Nitrobenzyloxycarbonyl Derivatives of 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)hydrazines

Shyam, Krishnamurthy ; Penketh, Philip G ; Shapiro, Maxim ; Belcourt, Michael F ; Loomis, Regina H ; Rockwell, Sara ; Sartorelli, Alan C

Journal of medicinal chemistry, 1999-03, Vol.42 (5), p.941-946 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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