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1 |
Material Type: Artigo
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COT drives resistance to RAF inhibition through MAP kinase pathway reactivationEmery, Caroline M ; Hieronymus, Haley ; Zhao, Jean J ; Boehm, Jesse S ; Golub, Todd ; Yang, Xiaoping ; Root, David E ; Roberts, Thomas M ; Hahn, William C ; Hill, David E ; Wilson, Christopher J ; Weber, Barbara L ; Garraway, Levi A ; Johnson, Laura A ; Kim, Sungjoon ; Harris, Jennifer L ; Kim, So Young ; Vidal, Marc ; Finan, Peter M ; Myer, Vic E ; Sellers, William R ; Barretina, Jordi ; Alkan, Ozan ; Thomas, Sapana R ; Wardwell, Leslie ; Cogdill, Alexandria P ; Dummer, Reinhard ; Schlegel, Robert ; Stransky, Nicolas ; Flaherty, Keith T ; Wargo, Jennifer A ; Murray, Ryan R ; Johannessen, Cory M ; Salehi-Ashtiani, Kourosh ; Caponigro, GiordanoNature (London), 2010-12, Vol.468 (7326), p.968-972 [Periódico revisado por pares]London: Nature Publishing GroupTexto completo disponível |
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Material Type: Artigo
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Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitorsWILSON, Timothy R ; FRIDLYAND, Jane ; RIBAS, Antoni ; JIANG LI ; MOFFAT, John ; SUTHERLIN, Daniel P ; KOEPPEN, Hartmut ; MERCHANT, Mark ; NEVE, Richard ; SETTLEMAN, Jeff ; YIBING YAN ; PENUEL, Elicia ; BURTON, Luciana ; CHAN, Emily ; JING PENG ; EVA LIN ; YULEI WANG ; SOSMAN, JeffNature (London), 2012-07, Vol.487 (7408), p.505-509 [Periódico revisado por pares]London: Nature Publishing GroupTexto completo disponível |
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Material Type: Artigo
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Systematic identification of genomic markers of drug sensitivity in cancer cellsGARNETT, Mathew J ; EDELMAN, Elena J ; QINGSONG LIU ; IORIO, Francesco ; SURDEZ, Didier ; LI CHEN ; MILANO, Randy J ; BIGNELL, Graham R ; TAM, Ah T ; DAVIES, Helen ; STEVENSON, Jesse A ; BARTHORPE, Syd ; HEIDORN, Sonja J ; LUTZ, Stephen R ; KOGERA, Fiona ; LAWRENCE, Karl ; MCLAREN-DOUGLAS, Anne ; MITROPOULOS, Xeni ; MIRONENKO, Tatiana ; THI, Helen ; RICHARDSON, Laura ; WENJUN ZHOU ; JEWITT, Frances ; GREENMAN, Chris D ; TINGHU ZHANG ; O'BRIEN, Patrick ; BOISVERT, Jessica L ; PRICE, Stacey ; HUR, Wooyoung ; WANJUAN YANG ; XIANMING DENG ; BUTLER, Adam ; HWAN GEUN CHOI ; JAE WON CHANG ; DASTUR, Anahita ; BASELGA, Jose ; STAMENKOVIC, Ivan ; ENGELMAN, Jeffrey A ; SHARMA, Sreenath V ; DELATTRE, Olivier ; SAEZ-RODRIGUEZ, Julio ; GRAY, Nathanael S ; SETTLEMAN, Jeffrey ; ANDREW FUTREAL, P ; HABER, Daniel A ; KING WAI LAU ; STRATTON, Michael R ; RAMASWAMY, Sridhar ; MCDERMOTT, Ultan ; BENES, Cyril H ; GRENINGER, Patricia ; RICHARD THOMPSON, I ; XI LUO ; SOARES, JorgeNature (London), 2012-03, Vol.483 (7391), p.570-575 [Periódico revisado por pares]London: Nature Publishing GroupTexto completo disponível |
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Material Type: Artigo
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Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFRPRAHALLAD, Anirudh ; CHONG SUN ; SIDONG HUANG ; DI NICOLANTONIO, Federica ; SALAZAR, Ramon ; ZECCHIN, Davide ; BEIJERSBERGEN, Roderick L ; BARDELLI, Alberto ; BERNARDS, RenéNature (London), 2012-01, Vol.483 (7387), p.100-103 [Periódico revisado por pares]London: Nature Publishing GroupTexto completo disponível |
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Material Type: Artigo
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Spread of Artemisinin Resistance in Plasmodium falciparum MalariaAshley, Elizabeth A ; Dhorda, Mehul ; Fairhurst, Rick M ; Amaratunga, Chanaki ; Lim, Parath ; Suon, Seila ; Sreng, Sokunthea ; Anderson, Jennifer M ; Mao, Sivanna ; Sam, Baramey ; Sopha, Chantha ; Chuor, Char Meng ; Nguon, Chea ; Sovannaroth, Siv ; Pukrittayakamee, Sasithon ; Jittamala, Podjanee ; Chotivanich, Kesinee ; Chutasmit, Kitipumi ; Suchatsoonthorn, Chaiyaporn ; Runcharoen, Ratchadaporn ; Hien, Tran Tinh ; Thuy-Nhien, Nguyen Thanh ; Thanh, Ngo Viet ; Phu, Nguyen Hoan ; Htut, Ye ; Han, Kay-Thwe ; Aye, Kyin Hla ; Mokuolu, Olugbenga A ; Olaosebikan, Rasaq R ; Folaranmi, Olaleke O ; Mayxay, Mayfong ; Khanthavong, Maniphone ; Hongvanthong, Bouasy ; Newton, Paul N ; Onyamboko, Marie A ; Fanello, Caterina I ; Tshefu, Antoinette K ; Mishra, Neelima ; Valecha, Neena ; Phyo, Aung Pyae ; Nosten, Francois ; Yi, Poravuth ; Tripura, Rupam ; Borrmann, Steffen ; Bashraheil, Mahfudh ; Peshu, Judy ; Faiz, M. Abul ; Ghose, Aniruddha ; Hossain, M. Amir ; Samad, Rasheda ; Rahman, M. Ridwanur ; Hasan, M. Mahtabuddin ; Islam, Akhterul ; Miotto, Olivo ; Amato, Roberto ; MacInnis, Bronwyn ; Stalker, Jim ; Kwiatkowski, Dominic P ; Bozdech, Zbynek ; Jeeyapant, Atthanee ; Cheah, Phaik Yeong ; Sakulthaew, Tharisara ; Chalk, Jeremy ; Intharabut, Benjamas ; Silamut, Kamolrat ; Lee, Sue J ; Vihokhern, Benchawan ; Kunasol, Chanon ; Imwong, Mallika ; Tarning, Joel ; Taylor, Walter J ; Yeung, Shunmay ; Woodrow, Charles J ; Flegg, Jennifer A ; Das, Debashish ; Smith, Jeffery ; Venkatesan, Meera ; Plowe, Christopher V ; Stepniewska, Kasia ; Guerin, Philippe J ; Dondorp, Arjen M ; Day, Nicholas P ; White, Nicholas JThe New England journal of medicine, 2014-07, Vol.371 (5), p.411-423 [Periódico revisado por pares]Waltham, MA: Massachusetts Medical SocietyTexto completo disponível |
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Material Type: Artigo
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Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretionSTRAUSSMAN, Ravid ; MORIKAWA, Teppei ; COOPER, Zachary A ; CHAPMAN, Paul B ; SOLIT, David B ; RIBAS, Antoni ; LO, Roger S ; FLAHERTY, Keith T ; OGINO, Shuji ; WARGO, Jennifer A ; GOLUB, Todd R ; SHEE, Kevin ; BARZILY-ROKNI, Michal ; RONG QIAN, Zhi ; JINYAN DU ; DAVIS, Ashli ; MONGARE, Margaret M ; GOULD, Joshua ; FREDERICK, Dennie TNature (London), 2012-07, Vol.487 (7408), p.500-504 [Periódico revisado por pares]London: Nature Publishing GroupTexto completo disponível |
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Material Type: Artigo
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Trapping of PARP1 and PARP2 by Clinical PARP InhibitorsMURAI, Junko ; HUANG, Shar-Yin N ; BRATA DAS, Benu ; RENAUD, Amelie ; YIPING ZHANG ; DOROSHOW, James H ; JIUPING JI ; TAKEDA, Shunichi ; POMMIER, YvesCancer research (Chicago, Ill.), 2012-11, Vol.72 (21), p.5588-5599 [Periódico revisado por pares]Philadelphia, PA: American Association for Cancer ResearchTexto completo disponível |
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Material Type: Artigo
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mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA AntagonistsLi, Nanxin ; Lee, Boyoung ; Liu, Rong-Jian ; Banasr, Mounira ; Dwyer, Jason M. ; Iwata, Masaaki ; Li, Xiao-Yuan ; Aghajanian, George ; Duman, Ronald S.Science (American Association for the Advancement of Science), 2010-08, Vol.329 (5994), p.959-964 [Periódico revisado por pares]Washington, DC: American Association for the Advancement of ScienceTexto completo disponível |
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Material Type: Artigo
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Antibiotics in early life alter the murine colonic microbiome and adiposityCHO, Ilseung ; YAMANISHI, Shingo ; HUILIN LI ; ALEKSEYENKO, Alexander V ; BLASER, Martin J ; COX, Laura ; METHE, Barbara A ; ZAVADIL, Jiri ; LI, Kelvin ; ZHAN GAO ; MAHANA, Douglas ; RAJU, Kartik ; TEITLER, IsabelNature (London), 2012-08, Vol.488 (7413), p.621-626 [Periódico revisado por pares]London: Nature Publishing GroupTexto completo disponível |
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Material Type: Artigo
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A restricted cell population propagates glioblastoma growth after chemotherapyJIAN CHEN ; YANJIAO LI ; YU, Tzong-Shiue ; MCKAY, Renee M ; BURNS, Dennis K ; KERNIE, Steven G ; PARADA, Luis FNature (London), 2012-08, Vol.488 (7412), p.522-526 [Periódico revisado por pares]London: Nature Publishing GroupTexto completo disponível |