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1
Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry
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Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry

Feng, Minghao ; Tang, Bingqing ; H. Liang, Steven ; Jiang, Xuefeng

Current topics in medicinal chemistry, 2016-01, Vol.16 (11), p.1200-1216 [Periódico revisado por pares]

Bentham Science Publishers Ltd

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2
Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy
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Artigo
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Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy

Huang, Ying ; Zhang, Jeff ; Yu, Zhengtian ; Zhang, Hailong ; Wang, Youzhen ; Lingel, Andreas ; Qi, Wei ; Gu, Justin ; Zhao, Kehao ; Shultz, Michael D ; Wang, Long ; Fu, Xingnian ; Sun, Yongfeng ; Zhang, Qiong ; Jiang, Xiangqing ; Zhang, Jiangwei ; Zhang, Chunye ; Li, Ling ; Zeng, Jue ; Feng, Lijian ; Zhang, Chao ; Liu, Yueqin ; Zhang, Man ; Zhang, Lijun ; Zhao, Mengxi ; Gao, Zhenting ; Liu, Xianghui ; Fang, Douglas ; Guo, Haibing ; Mi, Yuan ; Gabriel, Tobias ; Dillon, Michael P ; Atadja, Peter ; Oyang, Counde

Journal of medicinal chemistry, 2017-03, Vol.60 (6), p.2215-2226 [Periódico revisado por pares]

United States: American Chemical Society

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3
Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5‑Chloro‑N2‑(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)‑N4‑(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials
Material Type:
Artigo
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Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5‑Chloro‑N2‑(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)‑N4‑(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials

Marsilje, Thomas H ; Pei, Wei ; Chen, Bei ; Lu, Wenshuo ; Uno, Tetsuo ; Jin, Yunho ; Jiang, Tao ; Kim, Sungjoon ; Li, Nanxin ; Warmuth, Markus ; Sarkisova, Yelena ; Sun, Frank ; Steffy, Auzon ; Pferdekamper, AnneMarie C ; Li, Allen G ; Joseph, Sean B ; Kim, Young ; Liu, Bo ; Tuntland, Tove ; Cui, Xiaoming ; Gray, Nathanael S ; Steensma, Ruo ; Wan, Yongqin ; Jiang, Jiqing ; Chopiuk, Greg ; Li, Jie ; Gordon, W. Perry ; Richmond, Wendy ; Johnson, Kevin ; Chang, Jonathan ; Groessl, Todd ; He, You-Qun ; Phimister, Andrew ; Aycinena, Alex ; Lee, Christian C ; Bursulaya, Badry ; Karanewsky, Donald S ; Seidel, H. Martin ; Harris, Jennifer L ; Michellys, Pierre-Yves

Journal of medicinal chemistry, 2013-07, Vol.56 (14), p.5675-5690 [Periódico revisado por pares]

United States: American Chemical Society

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4
Development and optimization of halogenated vinyl sulfones as Nrf2 activators for the treatment of Parkinson’s disease
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Artigo
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Development and optimization of halogenated vinyl sulfones as Nrf2 activators for the treatment of Parkinson’s disease

Choi, Ji Won ; Kim, Siwon ; Yoo, Jong Seok ; Kim, Hyeon Jeong ; Kim, Hyeon Ji ; Kim, Byung Eun ; Lee, Elijah Hwejin ; Lee, Yong Sup ; Park, Jong-Hyun ; Park, Ki Duk

European journal of medicinal chemistry, 2021-02, Vol.212, p.113103, Article 113103 [Periódico revisado por pares]

France: Elsevier Masson SAS

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5
Synthesis and antibacterial and antifungal evaluation of some chalcone based sulfones and bisulfones
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Artigo
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Synthesis and antibacterial and antifungal evaluation of some chalcone based sulfones and bisulfones

Konduru, Naveen Kumar ; Dey, Sunita ; Sajid, Mohammad ; Owais, Mohammad ; Ahmed, Naseem

European journal of medicinal chemistry, 2013-01, Vol.59, p.23-30 [Periódico revisado por pares]

France: Elsevier Masson SAS

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6
Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B
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Artigo
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Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B

Chen, Peiling ; Chaikuad, Apirat ; Bamborough, Paul ; Bantscheff, Marcus ; Bountra, Chas ; Chung, Chun-wa ; Fedorov, Oleg ; Grandi, Paola ; Jung, David ; Lesniak, Robert ; Lindon, Matthew ; Müller, Susanne ; Philpott, Martin ; Prinjha, Rab ; Rogers, Catherine ; Selenski, Carolyn ; Tallant, Cynthia ; Werner, Thilo ; Willson, Timothy M ; Knapp, Stefan ; Drewry, David H

Journal of medicinal chemistry, 2016-02, Vol.59 (4), p.1410-1424 [Periódico revisado por pares]

United States: American Chemical Society

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7
Design, synthesis, and antibacterial activity against rice bacterial leaf blight and leaf streak of 2,5-substituted-1,3,4-oxadiazole/thiadiazole sulfone derivative
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Artigo
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Design, synthesis, and antibacterial activity against rice bacterial leaf blight and leaf streak of 2,5-substituted-1,3,4-oxadiazole/thiadiazole sulfone derivative

Li, Pei ; Shi, Li ; Yang, Xia ; Yang, Lei ; Chen, Xue-Wen ; Wu, Fang ; Shi, Qing-Cai ; Xu, Wei-Ming ; He, Ming ; Hu, De-Yu ; Song, Bao-An

Bioorganic & medicinal chemistry letters, 2014-04, Vol.24 (7), p.1677-1680 [Periódico revisado por pares]

England: Elsevier Ltd

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8
Recent applications of vinyl sulfone motif in drug design and discovery
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Artigo
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Recent applications of vinyl sulfone motif in drug design and discovery

Ahmadi, Reza ; Emami, Saeed

European journal of medicinal chemistry, 2022-04, Vol.234, p.114255-114255, Article 114255 [Periódico revisado por pares]

France: Elsevier Masson SAS

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9
AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2
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Artigo
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AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2

Narjes, Frank ; Llinas, Antonio ; von Berg, Stefan ; Jirholt, Johan ; Lever, Sarah ; Pehrson, Rikard ; Collins, Mia ; Malmberg, Anna ; Svanberg, Petter ; Xue, Yafeng ; Olsson, Roine I ; Malmberg, Jesper ; Hughes, Glyn ; Hossain, Nafizal ; Grindebacke, Hanna ; Leffler, Agnes ; Krutrök, Nina ; Bäck, Elisabeth ; Ramnegård, Marie ; Lepistö, Matti ; Thunberg, Linda ; Aagaard, Anna ; McPheat, Jane ; Hansson, Eva L ; Chen, Rongfeng ; Xiong, Yao ; Hansson, Thomas G

Journal of medicinal chemistry, 2021-09, Vol.64 (18), p.13807-13829 [Periódico revisado por pares]

United States: American Chemical Society

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10
Comparative toxicokinetics of bisphenol S in rats and mice following gavage administration
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Artigo
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Comparative toxicokinetics of bisphenol S in rats and mice following gavage administration

Waidyanatha, Suramya ; Black, Sherry R. ; Silinski, Melanie ; Sutherland, Vicki ; Fletcher, Brenda L. ; Fernando, Reshan A. ; Fennell, Timothy R.

Toxicology and applied pharmacology, 2020-11, Vol.406, p.115207-115207, Article 115207 [Periódico revisado por pares]

United States: Elsevier Inc

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