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Refinado por: Nome da Publicação: Journal Of Medicinal Chemistry remover assunto: Life Sciences & Biomedicine remover
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1
FragLitesMinimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation
FragLitesMinimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation
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FragLitesMinimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation

Wood, Daniel J ; Lopez-Fernandez, J. Daniel ; Knight, Leanne E ; Al-Khawaldeh, Islam ; Gai, Conghao ; Lin, Shengying ; Martin, Mathew P ; Miller, Duncan C ; Cano, Céline ; Endicott, Jane A ; Hardcastle, Ian R ; Noble, Martin E. M ; Waring, Michael J

Journal of medicinal chemistry, 2019-04, Vol.62 (7), p.3741-3752 [Periódico revisado por pares]

United States: American Chemical Society

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2
Cyclin-Dependent Kinase (CDK) Inhibitors: Structure–Activity Relationships and Insights into the CDK‑2 Selectivity of 6‑Substituted 2‑Arylaminopurines
Cyclin-Dependent Kinase (CDK) Inhibitors: Structure–Activity Relationships and Insights into the CDK‑2 Selectivity of 6‑Substituted 2‑Arylaminopurines
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Cyclin-Dependent Kinase (CDK) Inhibitors: Structure–Activity Relationships and Insights into the CDK‑2 Selectivity of 6‑Substituted 2‑Arylaminopurines

Coxon, Christopher R ; Anscombe, Elizabeth ; Harnor, Suzannah J ; Martin, Mathew P ; Carbain, Benoit ; Golding, Bernard T ; Hardcastle, Ian R ; Harlow, Lisa K ; Korolchuk, Svitlana ; Matheson, Christopher J ; Newell, David R ; Noble, Martin E. M ; Sivaprakasam, Mangaleswaran ; Tudhope, Susan J ; Turner, David M ; Wang, Lan Z ; Wedge, Stephen R ; Wong, Christopher ; Griffin, Roger J ; Endicott, Jane A ; Cano, Céline

Journal of medicinal chemistry, 2017-03, Vol.60 (5), p.1746-1767 [Periódico revisado por pares]

United States: American Chemical Society

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3
Identification of N‑{cis-3-[Methyl(7H‑pyrrolo[2,3‑d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases
Identification of N‑{cis-3-[Methyl(7H‑pyrrolo[2,3‑d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases
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Identification of N‑{cis-3-[Methyl(7H‑pyrrolo[2,3‑d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases

Vazquez, Michael L ; Kaila, Neelu ; Strohbach, Joseph W ; Trzupek, John D ; Brown, Matthew F ; Flanagan, Mark E ; Mitton-Fry, Mark J ; Johnson, Timothy A ; TenBrink, Ruth E ; Arnold, Eric P ; Basak, Arindrajit ; Heasley, Steven E ; Kwon, Soojin ; Langille, Jonathan ; Parikh, Mihir D ; Griffin, Sarah H ; Casavant, Jeffrey M ; Duclos, Brian A ; Fenwick, Ashley E ; Harris, Thomas M ; Han, Seungil ; Caspers, Nicole ; Dowty, Martin E ; Yang, Xin ; Banker, Mary Ellen ; Hegen, Martin ; Symanowicz, Peter T ; Li, Li ; Wang, Lu ; Lin, Tsung H ; Jussif, Jason ; Clark, James D ; Telliez, Jean-Baptiste ; Robinson, Ralph P ; Unwalla, Ray

Journal of medicinal chemistry, 2018-02, Vol.61 (3), p.1130-1152 [Periódico revisado por pares]

United States: American Chemical Society

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4
Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction
Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction
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Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction

Chessari, Gianni ; Hardcastle, Ian R ; Ahn, Jong Sook ; Anil, Burcu ; Anscombe, Elizabeth ; Bawn, Ruth H ; Bevan, Luke D ; Blackburn, Timothy J ; Buck, Ildiko ; Cano, Celine ; Carbain, Benoit ; Castro, Juan ; Cons, Ben ; Cully, Sarah J ; Endicott, Jane A ; Fazal, Lynsey ; Golding, Bernard T ; Griffin, Roger J ; Haggerty, Karen ; Harnor, Suzannah J ; Hearn, Keisha ; Hobson, Stephen ; Holvey, Rhian S ; Howard, Steven ; Jennings, Claire E ; Johnson, Christopher N ; Lunec, John ; Miller, Duncan C ; Newell, David R ; Noble, Martin E. M ; Reeks, Judith ; Revill, Charlotte H ; Riedinger, Christiane ; St. Denis, Jeffrey D ; Tamanini, Emiliano ; Thomas, Huw ; Thompson, Neil T ; Vinković, Mladen ; Wedge, Stephen R ; Williams, Pamela A ; Wilsher, Nicola E ; Zhang, Bian ; Zhao, Yan

Journal of medicinal chemistry, 2021-04, Vol.64 (7), p.4071-4088 [Periódico revisado por pares]

United States: American Chemical Society

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5
An Alkynylpyrimidine-Based Covalent Inhibitor That Targets a Unique Cysteine in NF-κB-Inducing Kinase
An Alkynylpyrimidine-Based Covalent Inhibitor That Targets a Unique Cysteine in NF-κB-Inducing Kinase
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An Alkynylpyrimidine-Based Covalent Inhibitor That Targets a Unique Cysteine in NF-κB-Inducing Kinase

Al-Khawaldeh, Islam ; Al Yasiri, Mohammed J ; Aldred, Gregory G ; Basmadjian, Christine ; Bordoni, Cinzia ; Harnor, Suzannah J ; Heptinstall, Amy B ; Hobson, Stephen J ; Jennings, Claire E ; Khalifa, Shaimaa ; Lebraud, Honorine ; Martin, Mathew P ; Miller, Duncan C ; Shrives, Harry J ; de Souza, João V ; Stewart, Hannah L ; Temple, Max ; Thomas, Huw D ; Totobenazara, Jane ; Tucker, Julie A ; Tudhope, Susan J ; Wang, Lan Z ; Bronowska, Agnieszka K ; Cano, Céline ; Endicott, Jane A ; Golding, Bernard T ; Hardcastle, Ian R ; Hickson, Ian ; Wedge, Stephen R ; Willmore, Elaine ; Noble, Martin E. M ; Waring, Michael J

Journal of medicinal chemistry, 2021-07, Vol.64 (14), p.10001-10018 [Periódico revisado por pares]

United States: American Chemical Society

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6
Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein−Protein Interaction: Structure−Activity Studies Leading to Improved Potency
Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein−Protein Interaction: Structure−Activity Studies Leading to Improved Potency
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Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein−Protein Interaction: Structure−Activity Studies Leading to Improved Potency

Hardcastle, Ian R ; Liu, Junfeng ; Valeur, Eric ; Watson, Anna ; Ahmed, Shafiq U ; Blackburn, Timothy J ; Bennaceur, Karim ; Clegg, William ; Drummond, Catherine ; Endicott, Jane A ; Golding, Bernard T ; Griffin, Roger J ; Gruber, Jan ; Haggerty, Karen ; Harrington, Ross W ; Hutton, Claire ; Kemp, Stuart ; Lu, Xiaohong ; McDonnell, James M ; Newell, David R ; Noble, Martin E. M ; Payne, Sara L ; Revill, Charlotte H ; Riedinger, Christiane ; Xu, Qing ; Lunec, John

Journal of medicinal chemistry, 2011-03, Vol.54 (5), p.1233-1243 [Periódico revisado por pares]

United States: American Chemical Society

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7
Build–Couple–Transform: A Paradigm for Lead-like Library Synthesis with Scaffold Diversity
Build–Couple–Transform: A Paradigm for Lead-like Library Synthesis with Scaffold Diversity
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Build–Couple–Transform: A Paradigm for Lead-like Library Synthesis with Scaffold Diversity

Uguen, Mélanie ; Davison, Gemma ; Sprenger, Lukas J. ; Hunter, James H. ; Martin, Mathew P. ; Turberville, Shannon ; Watt, Jessica E. ; Golding, Bernard T. ; Noble, Martin E. M. ; Stewart, Hannah L. ; Waring, Michael J.

Journal of medicinal chemistry, 2022-08, Vol.65 (16), p.11322-11339 [Periódico revisado por pares]

American Chemical Society

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8
Targeting Cytotoxic Agents through EGFR-Mediated Covalent Binding and Release
Targeting Cytotoxic Agents through EGFR-Mediated Covalent Binding and Release
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Targeting Cytotoxic Agents through EGFR-Mediated Covalent Binding and Release

Morese, Pasquale A. ; Anthony, Nahoum ; Bodnarchuk, Michael ; Jennings, Claire ; Martin, Mathew P. ; Noble, Richard A. ; Phillips, Nicole ; Thomas, Huw D. ; Wang, Lan Z. ; Lister, Andrew ; Noble, Martin E. M. ; Ward, Richard A. ; Wedge, Stephen R. ; Stewart, Hannah L. ; Waring, Michael J.

Journal of medicinal chemistry, 2023-09, Vol.66 (17), p.12324-12341 [Periódico revisado por pares]

United States: American Chemical Society

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9
Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases
Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases
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Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases

Gerstenberger, Brian S ; Ambler, Catherine ; Arnold, Eric P ; Banker, Mary-Ellen ; Brown, Matthew F ; Clark, James D ; Dermenci, Alpay ; Dowty, Martin E ; Fensome, Andrew ; Fish, Susan ; Hayward, Matthew M ; Hegen, Martin ; Hollingshead, Brett D ; Knafels, John D ; Lin, David W ; Lin, Tsung H ; Owen, Dafydd R ; Saiah, Eddine ; Sharma, Raman ; Vajdos, Felix F ; Xing, Li ; Yang, Xiaojing ; Yang, Xin ; Wright, Stephen W

Journal of medicinal chemistry, 2020-11, Vol.63 (22), p.13561-13577 [Periódico revisado por pares]

United States: American Chemical Society

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10
Birinapant, a Smac-Mimetic with Improved Tolerability for the Treatment of Solid Tumors and Hematological Malignancies
Birinapant, a Smac-Mimetic with Improved Tolerability for the Treatment of Solid Tumors and Hematological Malignancies
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Birinapant, a Smac-Mimetic with Improved Tolerability for the Treatment of Solid Tumors and Hematological Malignancies

Condon, Stephen M ; Mitsuuchi, Yasuhiro ; Deng, Yijun ; LaPorte, Matthew G ; Rippin, Susan R ; Haimowitz, Thomas ; Alexander, Matthew D ; Kumar, Pavan Tirunahari ; Hendi, Mukta S ; Lee, Yu-Hua ; Benetatos, Christopher A ; Yu, Guangyao ; Kapoor, Gurpreet Singh ; Neiman, Eric ; Seipel, Martin E ; Burns, Jennifer M ; Graham, Martin A ; McKinlay, Mark A ; Li, Xiaochun ; Wang, Jiawei ; Shi, Yigong ; Feltham, Rebecca ; Bettjeman, Bodhi ; Cumming, Mathew H ; Vince, James E ; Khan, Nufail ; Silke, John ; Day, Catherine L ; Chunduru, Srinivas K

Journal of medicinal chemistry, 2014-05, Vol.57 (9), p.3666-3677 [Periódico revisado por pares]

United States: American Chemical Society

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