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1
Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial
Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial
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Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial

Bissler, John J, Prof ; Kingswood, J Christopher, FRCP ; Radzikowska, Elżbieta, MD ; Zonnenberg, Bernard A, MD ; Frost, Michael, MD ; Belousova, Elena, Prof ; Sauter, Matthias, MD ; Nonomura, Norio, Prof ; Brakemeier, Susanne, MD ; de Vries, Petrus J, Prof ; Whittemore, Vicky H, PhD ; Chen, David, PhD ; Sahmoud, Tarek, MD ; Shah, Gaurav, MD ; Lincy, Jeremie, MS ; Lebwohl, David, MD ; Budde, Klemens, Prof

The Lancet (British edition), 2013-03, Vol.381 (9869), p.817-824 [Periódico revisado por pares]

Kidlington: Elsevier

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2
Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial
Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial
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Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial

Fuchs, Charles S, Dr Prof ; Tomasek, Jiri, MD ; Yong, Cho Jae, Prof ; Dumitru, Filip, MD ; Passalacqua, Rodolfo, MD ; Goswami, Chanchal, Prof ; Safran, Howard, Prof ; dos Santos, Lucas Vieira, MD ; Aprile, Giuseppe, MD ; Ferry, David R, Prof ; Melichar, Bohuslav, Prof ; Tehfe, Mustapha, MD ; Topuzov, Eldar, Prof ; Zalcberg, John Raymond, Prof ; Chau, Ian, MD ; Campbell, William, Prof ; Sivanandan, Choondal, MD ; Pikiel, Joanna, MD ; Koshiji, Minori, MD ; Hsu, Yanzhi, PhD ; Liepa, Astra M, PharmD ; Gao, Ling, PhD ; Schwartz, Jonathan D, MD ; Tabernero, Josep, MD

The Lancet (British edition), 2014-01, Vol.383 (9911), p.31-39 [Periódico revisado por pares]

Kidlington: Elsevier Ltd

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3
Autonomic Denervation Added to Pulmonary Vein Isolation for Paroxysmal Atrial Fibrillation: A Randomized Clinical Trial
Autonomic Denervation Added to Pulmonary Vein Isolation for Paroxysmal Atrial Fibrillation: A Randomized Clinical Trial
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Autonomic Denervation Added to Pulmonary Vein Isolation for Paroxysmal Atrial Fibrillation: A Randomized Clinical Trial

KATRITSIS, Demosthenes G ; POKUSHALOV, Evgeny ; ROMANOV, Alexander ; GIAZITZOGLOU, Eleftherios ; SIONTIS, George C. M ; PO, Sunny S ; CAMM, A. John ; IOANNIDIS, John P. A

Journal of the American College of Cardiology, 2013-12, Vol.62 (24), p.2318-2325 [Periódico revisado por pares]

New York, NY: Elsevier

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4
Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-1): a phase 3, randomised, double-blind, placebo-controlled trial
Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-1): a phase 3, randomised, double-blind, placebo-controlled trial
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Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-1): a phase 3, randomised, double-blind, placebo-controlled trial

Jacobson, Ira M, Prof ; Dore, Gregory J, Prof ; Foster, Graham R, Prof ; Fried, Michael W, Prof ; Radu, Monica, MD ; Rafalsky, Vladimir V, Prof ; Moroz, Larysa, Prof ; Craxi, Antonio, Prof ; Peeters, Monika, MSc ; Lenz, Oliver, PhD ; Ouwerkerk-Mahadevan, Sivi, PhD ; De La Rosa, Guy, MD ; Kalmeijer, Ronald, MD ; Scott, Jane, PhD ; Sinha, Rekha, PhD ; Beumont-Mauviel, Maria, PhD

The Lancet (British edition), 2014-08, Vol.384 (9941), p.403-413 [Periódico revisado por pares]

Kidlington: Elsevier Ltd

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5
Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial
Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial
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Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial

Franz, David Neal, Prof ; Belousova, Elena, MD ; Sparagana, Steven, MD ; Bebin, E Martina, MD ; Frost, Michael, MD ; Kuperman, Rachel, MD ; Witt, Olaf, MD ; Kohrman, Michael H, MD ; Flamini, J Robert, MD ; Wu, Joyce Y, MD ; Curatolo, Paolo, Prof ; de Vries, Petrus J, Prof ; Whittemore, Vicky H, PhD ; Thiele, Elizabeth A, MD ; Ford, James P, MS ; Shah, Gaurav, MD ; Cauwel, Helene, MSc ; Lebwohl, David, MD ; Sahmoud, Tarek, MD ; Jozwiak, Sergiusz, MD

The Lancet (British edition), 2013-01, Vol.381 (9861), p.125-132 [Periódico revisado por pares]

Kidlington: Elsevier Ltd

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6
Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial
Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial
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Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial

Navarra, Sandra V, MD ; Guzmán, Renato M, MD ; Gallacher, Alberto E, MD ; Hall, Stephen, MD ; Levy, Roger A, MD ; Jimenez, Renato E, MD ; Li, Edmund K-M, MD ; Thomas, Mathew, MD ; Kim, Ho-Youn, MD ; León, Manuel G, MD ; Tanasescu, Coman, MD ; Nasonov, Eugeny, MD ; Lan, Joung-Liang, MD ; Pineda, Lilia, MD ; Zhong, Z John, PhD ; Freimuth, William, MD ; Petri, Michelle A, MD

The Lancet (British edition), 2011, Vol.377 (9767), p.721-731 [Periódico revisado por pares]

Kidlington: Elsevier Ltd

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7
Eribulin monotherapy versus treatment of physician's choice in patients with metastatic breast cancer (EMBRACE): a phase 3 open-label randomised study
Eribulin monotherapy versus treatment of physician's choice in patients with metastatic breast cancer (EMBRACE): a phase 3 open-label randomised study
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Eribulin monotherapy versus treatment of physician's choice in patients with metastatic breast cancer (EMBRACE): a phase 3 open-label randomised study

Cortes, Javier, MD ; O'Shaughnessy, Joyce, MD ; Loesch, David, MD ; Blum, Joanne L, MD ; Vahdat, Linda T, MD ; Petrakova, Katarina, MD ; Chollet, Philippe, MD ; Manikas, Alexey, MD ; Diéras, Veronique, MD ; Delozier, Thierry, MD ; Vladimirov, Vladimir, MD ; Cardoso, Fatima, MD ; Koh, Han, MD ; Bougnoux, Philippe, MD ; Dutcus, Corina E, MD ; Seegobin, Seth, MSc ; Mir, Denis, MSc ; Meneses, Nicole, MSHS ; Wanders, Jantien, MD ; Twelves, Chris, Prof

The Lancet (British edition), 2011-03, Vol.377 (9769), p.914-923 [Periódico revisado por pares]

Kidlington: Elsevier Ltd

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8
Efficacy and safety of ipilimumab monotherapy in patients with pretreated advanced melanoma: a multicenter single-arm phase II study
Efficacy and safety of ipilimumab monotherapy in patients with pretreated advanced melanoma: a multicenter single-arm phase II study
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Efficacy and safety of ipilimumab monotherapy in patients with pretreated advanced melanoma: a multicenter single-arm phase II study

O'Day, S.J. ; Maio, M. ; Chiarion-Sileni, V. ; Gajewski, T.F. ; Pehamberger, H. ; Bondarenko, I.N. ; Queirolo, P. ; Lundgren, L. ; Mikhailov, S. ; Roman, L. ; Verschraegen, C. ; Humphrey, R. ; Ibrahim, R. ; de Pril, V. ; Hoos, A. ; Wolchok, J.D.

Annals of oncology, 2010-08, Vol.21 (8), p.1712-1717 [Periódico revisado por pares]

Oxford: Elsevier Ltd

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9
Once-daily dolutegravir versus twice-daily raltegravir in antiretroviral-naive adults with HIV-1 infection (SPRING-2 study): 96 week results from a randomised, double-blind, non-inferiority trial
Once-daily dolutegravir versus twice-daily raltegravir in antiretroviral-naive adults with HIV-1 infection (SPRING-2 study): 96 week results from a randomised, double-blind, non-inferiority trial
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Once-daily dolutegravir versus twice-daily raltegravir in antiretroviral-naive adults with HIV-1 infection (SPRING-2 study): 96 week results from a randomised, double-blind, non-inferiority trial

Raffi, François, Prof ; Jaeger, Hans, MD ; Quiros-Roldan, Eugenia, MD ; Albrecht, Helmut, Prof ; Belonosova, Elena, MD ; Gatell, Jose M, Prof ; Baril, Jean-Guy, MD ; Domingo, Pere, MD ; Brennan, Clare, DPT ; Almond, Steve, MMath ; Min, Sherene, MD

The Lancet infectious diseases, 2013-11, Vol.13 (11), p.927-935 [Periódico revisado por pares]

London: Elsevier Ltd

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10
Efficacy and safety of NEPA, an oral combination of netupitant and palonosetron, for prevention of chemotherapy-induced nausea and vomiting following highly emetogenic chemotherapy: a randomized dose-ranging pivotal study
Efficacy and safety of NEPA, an oral combination of netupitant and palonosetron, for prevention of chemotherapy-induced nausea and vomiting following highly emetogenic chemotherapy: a randomized dose-ranging pivotal study
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Efficacy and safety of NEPA, an oral combination of netupitant and palonosetron, for prevention of chemotherapy-induced nausea and vomiting following highly emetogenic chemotherapy: a randomized dose-ranging pivotal study

Hesketh, P.J. ; Rossi, G. ; Rizzi, G. ; Palmas, M. ; Alyasova, A. ; Bondarenko, I. ; Lisyanskaya, A. ; Gralla, R.J.

Annals of oncology, 2014-07, Vol.25 (7), p.1340-1346 [Periódico revisado por pares]

Oxford: Elsevier Ltd

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