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1 |
Material Type: Artigo
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Automated design of ligands to polypharmacological profilesBESNARD, Jeremy ; FILIPPO RUDA, Gian ; SIMEONS, Frederick R. C ; STOJANOVSKI, Laste ; PRAT, Annik ; SEIDAH, Nabil G ; CONSTAM, Daniel B ; RICHARD BICKERTON, G ; READ, Kevin D ; WETSEL, William C ; GILBERT, Ian H ; ROTH, Bryan L ; SETOLA, Vincent ; HOPKINS, Andrew L ; ABECASSIS, Keren ; RODRIGUIZ, Ramona M ; HUANG, Xi-Ping ; NORVAL, Suzanne ; SASSANO, Maria F ; SHIN, Antony I ; WEBSTER, Lauren ANature (London), 2012-12, Vol.492 (7428), p.215-220 [Periódico revisado por pares]London: Nature Publishing GroupTexto completo disponível |
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Material Type: Artigo
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Immunity by formulation design: Induction of high CD8 + T-cell responses by poly(I:C) incorporated into the CAF01 adjuvant via a double emulsion methodNordly, Pernille ; Rose, Fabrice ; Christensen, Dennis ; Nielsen, Hanne Mørck ; Andersen, Peter ; Agger, Else Marie ; Foged, CamillaJournal of controlled release, 2011-03, Vol.150 (3), p.307-317 [Periódico revisado por pares]Kidlington: Elsevier B.VTexto completo disponível |
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Material Type: Artigo
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Potent memapsin 2 (β-secretase) inhibitors: Design, synthesis, protein-ligand X-ray structure, and in vivo evaluationGhosh, Arun K. ; Kumaragurubaran, Nagaswamy ; Hong, Lin ; Kulkarni, Sarang ; Xu, Xiaoming ; Miller, Heather B. ; Srinivasa Reddy, Dandepally ; Weerasena, Vajira ; Turner, Robert ; Chang, Wanpin ; Koelsch, Gerald ; Tang, JordanBioorganic & medicinal chemistry, 2008-02, Vol.18 (3), p.1031-1036 [Periódico revisado por pares]Oxford: Elsevier LtdTexto completo disponível |
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Material Type: Artigo
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Design and Synthesis of Aryl Diphenolic Azoles as Potent and Selective Estrogen Receptor-β LigandsMalamas, Michael S ; Manas, Eric S ; McDevitt, Robert E ; Gunawan, Iwan ; Xu, Zhang B ; Collini, Michael D ; Miller, Chris P ; Dinh, Tam ; Henderson, Ruth A ; Keith, James C ; Harris, Heather AJournal of medicinal chemistry, 2004-10, Vol.47 (21), p.5021-5040 [Periódico revisado por pares]Washington, DC: American Chemical SocietyTexto completo disponível |
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Material Type: Artigo
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Discovery of N-(2,6-Dimethylphenyl)-Substituted Semicarbazones as Anticonvulsants: Hybrid Pharmacophore-Based DesignYogeeswari, Perumal ; Sriram, Dharmarajan ; Thirumurugan, Rathinasabapathy ; Raghavendran, Jegadeesan Vaigunda ; Sudhan, Kannan ; Pavana, Roheeth Kumar ; Stables, JamesJournal of medicinal chemistry, 2005-10, Vol.48 (20), p.6202-6211 [Periódico revisado por pares]Washington, DC: American Chemical SocietyTexto completo disponível |
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Material Type: Artigo
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Design, Synthesis, and Biological Evaluation of New-Generation TaxoidsOjima, Iwao ; Chen, Jin ; Sun, Liang ; Borella, Christopher P ; Wang, Tao ; Miller, Michael L ; Lin, Songnian ; Geng, Xudong ; Kuznetsova, Larisa ; Qu, Chuanxing ; Gallager, David ; Zhao, Xianrui ; Zanardi, Ilaria ; Xia, Shujun ; Horwitz, Susan B ; Mallen-St. Clair, Jon ; Guerriero, Jennifer L ; Bar-Sagi, Dafna ; Veith, Jean M ; Pera, Paula ; Bernacki, Ralph JJournal of medicinal chemistry, 2008-06, Vol.51 (11), p.3203-3221 [Periódico revisado por pares]Washington, DC: American Chemical SocietyTexto completo disponível |
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Material Type: Artigo
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Design and Optimization of Reverse-Transcription Quantitative PCR ExperimentsTichopad, Ales ; Kitchen, Rob ; Riedmaier, Irmgard ; Becker, Christiane ; Stahlberg, Anders ; Kubista, MikaelClinical chemistry (Baltimore, Md.), 2009-10, Vol.55 (10), p.1816-1823 [Periódico revisado por pares]Washington, DC: Am Assoc Clin ChemTexto completo disponível |
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Material Type: Artigo
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Structure-Based Design, Synthesis, and A-Site rRNA Cocrystal Complexes of Functionally Novel Aminoglycoside Antibiotics: C2‘ ‘ Ether Analogues of ParomomycinHanessian, Stephen ; Szychowski, Janek ; Adhikari, Susanta Sekhar ; Vasquez, Guillermo ; Kandasamy, Pachamuthu ; Swayze, Eric E ; Migawa, Michael T ; Ranken, Ray ; François, Boris ; Wirmer-Bartoschek, Julia ; Kondo, Jiro ; Westhof, EricJournal of medicinal chemistry, 2007-05, Vol.50 (10), p.2352-2369 [Periódico revisado por pares]Washington, DC: American Chemical SocietyTexto completo disponível |
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Material Type: Artigo
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Design, synthesis and structure–activity relationship study of novel pyrazole-based heterocycles as potential antitumor agentsFarag, Ahmad M. ; Ali, Korany A.K. ; El-Debss, Taha M.A. ; Mayhoub, Abdelrahman S. ; Amr, Abdel-Galil E. ; Abdel-Hafez, Naglaa A. ; Abdulla, Mohamed M.European journal of medicinal chemistry, 2010-12, Vol.45 (12), p.5887-5898 [Periódico revisado por pares]Kidlington: Elsevier Masson SASTexto completo disponível |
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Material Type: Artigo
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A comparison of model-based (2D) and design-based (3D) stereological methods for estimating cell number in the substantia nigra pars compacta (SNpc) of the C57BL/6J mouseBaquet, Z.C ; Williams, D ; Brody, J ; Smeyne, R.JNeuroscience, 2009-07, Vol.161 (4), p.1082-1090 [Periódico revisado por pares]Amsterdam: Elsevier LtdTexto completo disponível |