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Material Type: Artigo
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Metabolism and pathways for denitration of organic nitrates in the human liverGovoni, Mirco ; Tocchetti, Paola ; Lundberg, Jon OThe Journal of pharmacology and experimental therapeutics, 2013-07, Vol.346 (1), p.96-104 [Periódico revisado por pares]United StatesTexto completo disponível |
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Material Type: Artigo
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Protein Kinase N Family Negatively Regulates Constitutive Androstane Receptor-Mediated Transcriptional Induction of Cytochrome P450 2b10 in the Livers of MiceKawase, Atsushi ; Mukai, Hideyuki ; Tateishi, Shunsuke ; Kuroda, Shintaro ; Kazaoka, Akira ; Satoh, Ryosuke ; Shimada, Hiroaki ; Sugiura, Reiko ; Iwaki, MasahiroThe Journal of pharmacology and experimental therapeutics, 2021-10, Vol.379 (1), p.53-63 [Periódico revisado por pares]United StatesTexto completo disponível |
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Material Type: Artigo
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The UDP-glucuronosyltransferase (UGT) 1A polymorphism c.2042C>G (rs8330) is associated with increased human liver acetaminophen glucuronidation, increased UGT1A exon 5a/5b splice variant mRNA ratio, and decreased risk of unintentional acetaminophen-induced acute liver failureCourt, Michael H ; Freytsis, Marina ; Wang, Xueding ; Peter, Inga ; Guillemette, Chantal ; Hazarika, Suwagmani ; Duan, Su X ; Greenblatt, David J ; Lee, William MThe Journal of pharmacology and experimental therapeutics, 2013-05, Vol.345 (2), p.297-307 [Periódico revisado por pares]United StatesTexto completo disponível |
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Material Type: Artigo
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Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interactionNishimura, Toshihiko ; Nishimura, Toshiko ; Hu, Yajing ; Wu, Manhong ; Pham, Edward ; Suemizu, Hiroshi ; Elazar, Menashe ; Liu, Michael ; Idilman, Ramazan ; Yurdaydin, Cihan ; Angus, Peter ; Stedman, Catherine ; Murphy, Brian ; Glenn, Jeffrey ; Nakamura, Masato ; Nomura, Tatsuji ; Chen, Yuan ; Zheng, Ming ; Fitch, William L ; Peltz, GaryThe Journal of pharmacology and experimental therapeutics, 2013-02, Vol.344 (2), p.388-396 [Periódico revisado por pares]United States: The American Society for Pharmacology and Experimental TherapeuticsTexto completo disponível |
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Material Type: Artigo
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Inhibition of Transporter-Mediated Hepatic Uptake as a Mechanism for Drug-Drug Interaction between Cerivastatin and Cyclosporin AShitara, Yoshihisa ; Itoh, Tomoo ; Sato, Hitoshi ; Li, Albert P ; Sugiyama, YuichiThe Journal of pharmacology and experimental therapeutics, 2003-02, Vol.304 (2), p.610-616 [Periódico revisado por pares]United States: American Society for Pharmacology and Experimental TherapeuticsTexto completo disponível |
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Material Type: Artigo
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A silybin-phospholipid complex prevents mitochondrial dysfunction in a rodent model of nonalcoholic steatohepatitisServiddio, Gaetano ; Bellanti, Francesco ; Giudetti, Anna Maria ; Gnoni, Gabriele Vincenzo ; Petrella, Antonio ; Tamborra, Rosanna ; Romano, Antonino Davide ; Rollo, Tiziana ; Vendemiale, Gianluigi ; Altomare, EmanueleThe Journal of pharmacology and experimental therapeutics, 2010-03, Vol.332 (3), p.922-932 [Periódico revisado por pares]United StatesTexto completo disponível |
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Material Type: Artigo
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Administration of Ampicillin Elevates Hepatic Primary Bile Acid Synthesis through Suppression of Ileal Fibroblast Growth Factor 15 ExpressionMiyata, Masaaki ; Takamatsu, Yuki ; Kuribayashi, Hideaki ; Yamazoe, YasushiThe Journal of pharmacology and experimental therapeutics, 2009-12, Vol.331 (3), p.1079-1085 [Periódico revisado por pares]United States: American Society for Pharmacology and Experimental TherapeuticsTexto completo disponível |
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Material Type: Artigo
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Hepatoprotective Activity of Liposomal Flavonoid against Arsenite-Induced Liver FibrosisMandal, Ardhendu K ; Das, Subhankar ; Basu, Mukul K ; Chakrabarti, Rohini N ; Das, NirmalenduThe Journal of pharmacology and experimental therapeutics, 2007-03, Vol.320 (3), p.994-1001 [Periódico revisado por pares]United States: American Society for Pharmacology and Experimental TherapeuticsTexto completo disponível |
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Material Type: Artigo
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Multiple Transporters Affect the Disposition of Atorvastatin and Its Two Active Hydroxy Metabolites: Application of in Vitro and ex Situ SystemsLau, Yvonne Y ; Okochi, Hideaki ; Huang, Yong ; Benet, Leslie ZThe Journal of pharmacology and experimental therapeutics, 2006-02, Vol.316 (2), p.762-771 [Periódico revisado por pares]United States: American Society for Pharmacology and Experimental TherapeuticsTexto completo disponível |
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Material Type: Artigo
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Differential effects of nicotine treatment and ethanol self-administration on CYP2A6, CYP2B6 and nicotine pharmacokinetics in African green monkeysFerguson, C S ; Miksys, S ; Palmour, R M ; Tyndale, R FThe Journal of pharmacology and experimental therapeutics, 2012-12, Vol.343 (3), p.628-637 [Periódico revisado por pares]United StatesTexto completo disponível |