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1
Discovery and activity of (1 R,4 S,6 R)- N-[(1 R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist
Discovery and activity of (1 R,4 S,6 R)- N-[(1 R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist
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Discovery and activity of (1 R,4 S,6 R)- N-[(1 R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist

Ye, Zhixiong ; Guo, Liangqin ; Barakat, Khaled J. ; Pollard, Patrick G. ; Palucki, Brenda L. ; Sebhat, Iyassu K. ; Bakshi, Raman K. ; Tang, Rui ; Kalyani, Rubana N. ; Vongs, Aurawan ; Chen, Airu S. ; Chen, Howard Y. ; Rosenblum, Charles I. ; MacNeil, Tanya ; Weinberg, David H. ; Peng, Qianping ; Tamvakopoulos, Constantin ; Miller, Randy R. ; Stearns, Ralph A. ; Cashen, Doreen E. ; Martin, William J. ; Metzger, Joseph M. ; Strack, Alison M. ; MacIntyre, D. Euan ; Van der Ploeg, Lex H.T. ; Patchett, Arthur A. ; Wyvratt, Matthew J. ; Nargund, Ravi P.

Bioorganic & medicinal chemistry letters, 2005-08, Vol.15 (15), p.3501-3505 [Periódico revisado por pares]

Oxford: Elsevier Ltd

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2
Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity
Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity
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Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity

Liu, Jian ; He, Shuwen ; Jian, Tianying ; Dobbelaar, Peter H. ; Sebhat, Iyassu K. ; Lin, Linus S. ; Goodman, Allan ; Guo, Cheng ; Guzzo, Peter R. ; Hadden, Mark ; Henderson, Alan J. ; Pattamana, Kevin ; Ruenz, Megan ; Sargent, Bruce J ; Swenson, Brian ; Yet, Larry ; Tamvakopoulos, Constantin ; Peng, Qianping ; Pan, Jie ; Kan, Yanqing ; Palyha, Oksana ; Kelly, Theresa M. ; Guan, Xiao-Ming ; Howard, Andrew D. ; Marsh, Donald J. ; Metzger, Joseph M. ; Reitman, Marc L. ; Wyvratt, Matthew J. ; Nargund, Ravi P.

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (7), p.2074-2077 [Periódico revisado por pares]

Amsterdam: Elsevier Ltd

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3
Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists
Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists
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Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists

He, Shuwen ; Dobbelaar, Peter H. ; Liu, Jian ; Jian, Tianying ; Sebhat, Iyassu K. ; Lin, Linus S. ; Goodman, Allan ; Guo, Cheng ; Guzzo, Peter R. ; Hadden, Mark ; Henderson, Alan J. ; Ruenz, Megan ; Sargent, Bruce J. ; Yet, Larry ; Kelly, Theresa M. ; Palyha, Oksana ; Kan, Yanqing ; Pan, Jie ; Chen, Howard ; Marsh, Donald J. ; Shearman, Lauren P. ; Strack, Alison M. ; Metzger, Joseph M. ; Feighner, Scott D. ; Tan, Carina ; Howard, Andrew D. ; Tamvakopoulos, Constantin ; Peng, Qianping ; Guan, Xiao-Ming ; Reitman, Marc L. ; Patchett, Arthur A. ; Wyvratt, Matthew J. ; Nargund, Ravi P.

Bioorganic & medicinal chemistry letters, 2010-03, Vol.20 (6), p.1913-1917 [Periódico revisado por pares]

Amsterdam: Elsevier Ltd

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4
Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands
Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands
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Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands

Hong, Qingmei ; Bakshi, Raman K. ; Dellureficio, James ; He, Shuwen ; Ye, Zhixiong ; Dobbelaar, Peter H. ; Sebhat, Iyassu K. ; Guo, Liangqin ; Liu, Jian ; Jian, Tianying ; Tang, Rui ; Kalyani, Rubana N. ; MacNeil, Tanya ; Vongs, Aurawan ; Rosenblum, Charles I. ; Weinberg, David H. ; Peng, Qingping ; Tamvakopoulos, Constantin ; Miller, Randy R. ; Stearns, Ralph A. ; Cashen, Doreen ; Martin, Willian J. ; Chen, Airu S. ; Metzger, Joseph M. ; Chen, Howard Y. ; Strack, Allison M. ; Fong, Tung M. ; Maclntyre, Euan ; Van der Ploeg, Lex H.T. ; Wyvratt, Matthew J. ; Nargund, Ravi P.

Bioorganic & medicinal chemistry letters, 2010-08, Vol.20 (15), p.4483-4486 [Periódico revisado por pares]

Amsterdam: Elsevier Ltd

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5
Synthesis and SAR of heterocyclic carboxylic acid isosteres based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity
Synthesis and SAR of heterocyclic carboxylic acid isosteres based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity
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Synthesis and SAR of heterocyclic carboxylic acid isosteres based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity

Hadden, Mark ; Goodman, Allan ; Guo, Cheng ; Guzzo, Peter R. ; Henderson, Alan J. ; Pattamana, Kevin ; Ruenz, Megan ; Sargent, Bruce J. ; Swenson, Brian ; Yet, Larry ; Liu, Jian ; He, Shuwen ; Sebhat, Iyassu K. ; Lin, Linus S. ; Tamvakopoulos, Constantin ; Peng, Qianping ; Kan, Yanqing ; Palyha, Oksana ; Kelly, Theresa M. ; Guan, Xiao-Ming ; Metzger, Joseph M. ; Reitman, Marc L. ; Nargund, Ravi P.

Bioorganic & medicinal chemistry letters, 2010-05, Vol.20 (9), p.2912-2915 [Periódico revisado por pares]

Amsterdam: Elsevier Ltd

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6
Benzyl vinylogous amide substituted aryldihydropyridazinones and aryldimethylpyrazolones as potent and selective PDE3B inhibitors
Benzyl vinylogous amide substituted aryldihydropyridazinones and aryldimethylpyrazolones as potent and selective PDE3B inhibitors
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Benzyl vinylogous amide substituted aryldihydropyridazinones and aryldimethylpyrazolones as potent and selective PDE3B inhibitors

Edmondson, Scott D. ; Mastracchio, Anthony ; He, Jiafang ; Chung, Christine C. ; Forrest, Michael J. ; Hofsess, Scott ; MacIntyre, Euan ; Metzger, Joseph ; O'Connor, Naphtali ; Patel, Kajal ; Tong, Xinchun ; Tota, Michael R. ; Van der Ploeg, Lex H.T. ; Varnerin, Jeff P. ; Fisher, Michael H. ; Wyvratt, Matthew J. ; Weber, Ann E. ; Parmee, Emma R.

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (22), p.3983-3987 [Periódico revisado por pares]

Oxford: Elsevier Ltd

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7
Aryloxazolidinediones: Identification of potent orally active PPAR dual α/γ agonists
Aryloxazolidinediones: Identification of potent orally active PPAR dual α/γ agonists
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Aryloxazolidinediones: Identification of potent orally active PPAR dual α/γ agonists

DESAI, Ranjit C ; GRATALE, Dominick F ; FRANKLIN, Ronald ; MOLLER, David E ; HECK, James V ; SAHOO, Soumya P ; WEI HAN ; KOYAMA, Hiroo ; METZGER, Edward ; LOMBARDO, Victoria K ; MACNAUL, Karen L ; DOEBBER, Thomas W ; BERGER, Joel P ; LEUNG, Kwan

Bioorganic & medicinal chemistry letters, 2003-10, Vol.13 (20), p.3541-3544 [Periódico revisado por pares]

Oxford: Elsevier

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