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Metabolism of Proline as Microenvironmental Stress Substrate
Metabolism of Proline as Microenvironmental Stress Substrate
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Metabolism of Proline as Microenvironmental Stress Substrate

Phang, James M ; Pandhare, Jui ; Liu, Yongmin

The Journal of nutrition, 2008-10, Vol.138 (10), p.2008S-2015S [Periódico revisado por pares]

Bethesda, MD: American Society for Nutrition

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2
Discovery of (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a Selective, Potent, Orally Bioavailable Hepatitis C Virus NS3 Protease Inhibitor:  A Potential Therapeutic Agent for the Treatment of Hepatitis C Infection
Discovery of (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a Selective, Potent, Orally Bioavailable Hepatitis C Virus NS3 Protease Inhibitor:  A Potential Therapeutic Agent for the Treatment of Hepatitis C Infection
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Discovery of (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a Selective, Potent, Orally Bioavailable Hepatitis C Virus NS3 Protease Inhibitor:  A Potential Therapeutic Agent for the Treatment of Hepatitis C Infection

Venkatraman, Srikanth ; Bogen, Stéphane L ; Arasappan, Ashok ; Bennett, Frank ; Chen, Kevin ; Jao, Edwin ; Liu, Yi-Tsung ; Lovey, Raymond ; Hendrata, Siska ; Huang, Yuhua ; Pan, Weidong ; Parekh, Tejal ; Pinto, Patrick ; Popov, Veljko ; Pike, Russel ; Ruan, Sumei ; Santhanam, Bama ; Vibulbhan, Bancha ; Wu, Wanli ; Yang, Weiying ; Kong, Jianshe ; Liang, Xiang ; Wong, Jesse ; Liu, Rong ; Butkiewicz, Nancy ; Chase, Robert ; Hart, Andrea ; Agrawal, Sony ; Ingravallo, Paul ; Pichardo, John ; Kong, Rong ; Baroudy, Bahige ; Malcolm, Bruce ; Guo, Zhuyan ; Prongay, Andrew ; Madison, Vincent ; Broske, Lisa ; Cui, Xiaoming ; Cheng, Kuo-Chi ; Hsieh, Yunsheng ; Brisson, Jean-Marc ; Prelusky, Danial ; Korfmacher, Walter ; White, Ronald ; Bogdanowich-Knipp, Susan ; Pavlovsky, Anastasia ; Bradley, Prudence ; Saksena, Anil K ; Ganguly, Ashit ; Piwinski, John ; Girijavallabhan, Viyyoor ; Njoroge, F. George

Journal of medicinal chemistry, 2006-10, Vol.49 (20), p.6074-6086 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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3
Fused bicyclic heteroarylpiperazine-substituted l-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group
Fused bicyclic heteroarylpiperazine-substituted l-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group
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Fused bicyclic heteroarylpiperazine-substituted l-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group

Yoshida, Tomohiro ; Akahoshi, Fumihiko ; Sakashita, Hiroshi ; Sonda, Shuji ; Takeuchi, Masahiro ; Tanaka, Yoshihito ; Nabeno, Mika ; Kishida, Hiroyuki ; Miyaguchi, Ikuko ; Hayashi, Yoshiharu

Bioorganic & medicinal chemistry, 2012-08, Vol.20 (16), p.5033-5041 [Periódico revisado por pares]

Amsterdam: Elsevier Ltd

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4
Discovery and Preclinical Profile of Saxagliptin (BMS-477118):  A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes
Discovery and Preclinical Profile of Saxagliptin (BMS-477118):  A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes
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Discovery and Preclinical Profile of Saxagliptin (BMS-477118):  A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

Augeri, David J ; Robl, Jeffrey A ; Betebenner, David A ; Magnin, David R ; Khanna, Ashish ; Robertson, James G ; Wang, Aiying ; Simpkins, Ligaya M ; Taunk, Prakash ; Huang, Qi ; Han, Song-Ping ; Abboa-Offei, Benoni ; Cap, Michael ; Xin, Li ; Tao, Li ; Tozzo, Effie ; Welzel, Gustav E ; Egan, Donald M ; Marcinkeviciene, Jovita ; Chang, Shu Y ; Biller, Scott A ; Kirby, Mark S ; Parker, Rex A ; Hamann, Lawrence G

Journal of medicinal chemistry, 2005-07, Vol.48 (15), p.5025-5037 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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5
Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets
Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets
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Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets

Myllyharju, Johanna

Annals of medicine (Helsinki), 2008, Vol.40 (6), p.402-417 [Periódico revisado por pares]

Basingstoke: Informa UK Ltd

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6
A Novel Class of Prolyl Hydroxylase Inhibitors Induces Angiogenesis and Exerts Organ Protection Against Ischemia
A Novel Class of Prolyl Hydroxylase Inhibitors Induces Angiogenesis and Exerts Organ Protection Against Ischemia
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A Novel Class of Prolyl Hydroxylase Inhibitors Induces Angiogenesis and Exerts Organ Protection Against Ischemia

Nangaku, Masaomi ; Izuhara, Yuko ; Takizawa, Shunya ; Yamashita, Toshiharu ; Fujii-Kuriyama, Yoshiaki ; Ohneda, Osamu ; Yamamoto, Masayuki ; van Ypersele de Strihou, Charles ; Hirayama, Noriaki ; Miyata, Toshio

Arteriosclerosis, thrombosis, and vascular biology, 2007-12, Vol.27 (12), p.2548-2554 [Periódico revisado por pares]

Philadelphia, PA: American Heart Association, Inc

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7
SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors
SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors
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SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors

Forsyth, Timothy ; Kearney, Patrick C. ; Kim, Byung Gyu ; Johnson, Henry W.B. ; Aay, Naing ; Arcalas, Arlyn ; Brown, David S. ; Chan, Vicky ; Chen, Jeff ; Du, Hongwang ; Epshteyn, Sergey ; Galan, Adam A. ; Huynh, Tai P. ; Ibrahim, Mohamed A. ; Kane, Brian ; Koltun, Elena S. ; Mann, Grace ; Meyr, Lisa E. ; Lee, Matthew S. ; Lewis, Gary L. ; Noguchi, Robin T. ; Pack, Michael ; Ridgway, Brian H. ; Shi, Xian ; Takeuchi, Craig S. ; Zu, Peiwen ; Leahy, James W. ; Nuss, John M. ; Aoyama, Ron ; Engst, Stefan ; Gendreau, Steven B. ; Kassees, Robert ; Li, Jia ; Lin, Shwu-Hwa ; Martini, Jean-Francois ; Stout, Thomas ; Tong, Philip ; Woolfrey, John ; Zhang, Wentao ; Yu, Peiwen

Bioorganic & medicinal chemistry letters, 2012-12, Vol.22 (24), p.7653-7658 [Periódico revisado por pares]

Amsterdam: Elsevier Ltd

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8
Discovery of BI 99179, a potent and selective inhibitor of type I fatty acid synthase with central exposure
Discovery of BI 99179, a potent and selective inhibitor of type I fatty acid synthase with central exposure
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Discovery of BI 99179, a potent and selective inhibitor of type I fatty acid synthase with central exposure

Kley, Jörg T. ; Mack, Jürgen ; Hamilton, Bradford ; Scheuerer, Stefan ; Redemann, Norbert

Bioorganic & medicinal chemistry letters, 2011-10, Vol.21 (19), p.5924-5927 [Periódico revisado por pares]

Amsterdam: Elsevier Ltd

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9
Proline bis-amides as potent dual orexin receptor antagonists
Proline bis-amides as potent dual orexin receptor antagonists
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Proline bis-amides as potent dual orexin receptor antagonists

Bergman, Jeffrey M. ; Roecker, Anthony J. ; Mercer, Swati P. ; Bednar, Rodney A. ; Reiss, Duane R. ; Ransom, Richard W. ; Meacham Harrell, C. ; Pettibone, Douglas J. ; Lemaire, Wei ; Murphy, Kathy L. ; Li, Chunze ; Prueksaritanont, Thomayant ; Winrow, Christopher J. ; Renger, John J. ; Koblan, Kenneth S. ; Hartman, George D. ; Coleman, Paul J.

Bioorganic & medicinal chemistry, 2008-02, Vol.18 (4), p.1425-1430 [Periódico revisado por pares]

Oxford: Elsevier Ltd

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10
HIF-Prolyl Hydroxylases in the Rat Kidney: Physiologic Expression Patterns and Regulation in Acute Kidney Injury
HIF-Prolyl Hydroxylases in the Rat Kidney: Physiologic Expression Patterns and Regulation in Acute Kidney Injury
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HIF-Prolyl Hydroxylases in the Rat Kidney: Physiologic Expression Patterns and Regulation in Acute Kidney Injury

Schodel, Johannes ; Klanke, Bernd ; Weidemann, Alexander ; Buchholz, Bjorn ; Bernhardt, Wanja ; Bertog, Marko ; Amann, Kerstin ; Korbmacher, Christoph ; Wiesener, Michael ; Warnecke, Christina ; Kurtz, Armin ; Eckardt, Kai-Uwe ; Willam, Carsten

The American journal of pathology, 2009-05, Vol.174 (5), p.1663-1674 [Periódico revisado por pares]

Bethesda, MD: ASIP

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