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11
Brain Concentrations of Methylone and Its Metabolites after Systemic Methylone Administration: Relationship to Pharmacodynamic Effects
Brain Concentrations of Methylone and Its Metabolites after Systemic Methylone Administration: Relationship to Pharmacodynamic Effects
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Brain Concentrations of Methylone and Its Metabolites after Systemic Methylone Administration: Relationship to Pharmacodynamic Effects

Centazzo, Nicole ; Chojnacki, Michael R ; Elmore, Joshua S ; Rodriguez, Raider ; Acosta, Teeshavi ; Suzuki, Masaki ; Rice, Kenner C ; Baumann, Michael H ; Concheiro, Marta

The Journal of pharmacology and experimental therapeutics, 2021-06, Vol.377 (3), p.398-406 [Periódico revisado por pares]

United States: The American Society for Pharmacology and Experimental Therapeutics

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12
SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D 2 Receptor Mechanism of Action
SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D 2 Receptor Mechanism of Action
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SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D 2 Receptor Mechanism of Action

Dedic, Nina ; Jones, Philip G ; Hopkins, Seth C ; Lew, Robert ; Shao, Liming ; Campbell, John E ; Spear, Kerry L ; Large, Thomas H ; Campbell, Una C ; Hanania, Taleen ; Leahy, Emer ; Koblan, Kenneth S

The Journal of pharmacology and experimental therapeutics, 2019-10, Vol.371 (1), p.1-14 [Periódico revisado por pares]

United States

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13
Tofogliflozin, a potent and highly specific sodium/glucose cotransporter 2 inhibitor, improves glycemic control in diabetic rats and mice
Tofogliflozin, a potent and highly specific sodium/glucose cotransporter 2 inhibitor, improves glycemic control in diabetic rats and mice
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Tofogliflozin, a potent and highly specific sodium/glucose cotransporter 2 inhibitor, improves glycemic control in diabetic rats and mice

Suzuki, Masayuki ; Honda, Kiyofumi ; Fukazawa, Masanori ; Ozawa, Kazuharu ; Hagita, Hitoshi ; Kawai, Takahiro ; Takeda, Minako ; Yata, Tatsuo ; Kawai, Mio ; Fukuzawa, Taku ; Kobayashi, Takamitsu ; Sato, Tsutomu ; Kawabe, Yoshiki ; Ikeda, Sachiya

The Journal of pharmacology and experimental therapeutics, 2012-06, Vol.341 (3), p.692-701 [Periódico revisado por pares]

United States

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14
Seletalisib: Characterization of a Novel, Potent, and Selective Inhibitor of PI3K δ
Seletalisib: Characterization of a Novel, Potent, and Selective Inhibitor of PI3K δ
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Seletalisib: Characterization of a Novel, Potent, and Selective Inhibitor of PI3K δ

Allen, Rodger A ; Brookings, Daniel C ; Powell, Mark J ; Delgado, Jean ; Shuttleworth, Lindsay K ; Merriman, Mark ; Fahy, Ian J ; Tewari, Roohi ; Silva, John P ; Healy, Louise J ; Davies, Gareth C G ; Twomey, Breda ; Cutler, Rona M ; Kotian, Apoorva ; Crosby, Andrea ; McCluskey, Gillian ; Watt, Gillian F ; Payne, Andrew

The Journal of pharmacology and experimental therapeutics, 2017-06, Vol.361 (3), p.429-440 [Periódico revisado por pares]

United States

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15
(R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a Novel Xanthine-Based Dipeptidyl Peptidase 4 Inhibitor, Has a Superior Potency and Longer Duration of Action Compared with Other Dipeptidyl Peptidase-4 Inhibitors
(R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a Novel Xanthine-Based Dipeptidyl Peptidase 4 Inhibitor, Has a Superior Potency and Longer Duration of Action Compared with Other Dipeptidyl Peptidase-4 Inhibitors
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(R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a Novel Xanthine-Based Dipeptidyl Peptidase 4 Inhibitor, Has a Superior Potency and Longer Duration of Action Compared with Other Dipeptidyl Peptidase-4 Inhibitors

Thomas, Leo ; Eckhardt, Matthias ; Langkopf, Elke ; Tadayyon, Moh ; Himmelsbach, Frank ; Mark, Michael

The Journal of pharmacology and experimental therapeutics, 2008-04, Vol.325 (1), p.175-182 [Periódico revisado por pares]

United States: American Society for Pharmacology and Experimental Therapeutics

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16
Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator
Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator
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Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator

Maeda, Kenji ; Sugino, Haruhiko ; Akazawa, Hitomi ; Amada, Naoki ; Shimada, Jun ; Futamura, Takashi ; Yamashita, Hiroshi ; Ito, Nobuaki ; McQuade, Robert D ; Mørk, Arne ; Pehrson, Alan L ; Hentzer, Morten ; Nielsen, Vibeke ; Bundgaard, Christoffer ; Arnt, Jørn ; Stensbøl, Tine Bryan ; Kikuchi, Tetsuro

The Journal of pharmacology and experimental therapeutics, 2014-09, Vol.350 (3), p.589-604 [Periódico revisado por pares]

United States

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17
CHF6001 I: a novel highly potent and selective phosphodiesterase 4 inhibitor with robust anti-inflammatory activity and suitable for topical pulmonary administration
CHF6001 I: a novel highly potent and selective phosphodiesterase 4 inhibitor with robust anti-inflammatory activity and suitable for topical pulmonary administration
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CHF6001 I: a novel highly potent and selective phosphodiesterase 4 inhibitor with robust anti-inflammatory activity and suitable for topical pulmonary administration

Moretto, Nadia ; Caruso, Paola ; Bosco, Raffaella ; Marchini, Gessica ; Pastore, Fiorella ; Armani, Elisabetta ; Amari, Gabriele ; Rizzi, Andrea ; Ghidini, Eleonora ; De Fanti, Renato ; Capaldi, Carmelida ; Carzaniga, Laura ; Hirsch, Emilio ; Buccellati, Carola ; Sala, Angelo ; Carnini, Chiara ; Patacchini, Riccardo ; Delcanale, Maurizio ; Civelli, Maurizio ; Villetti, Gino ; Facchinetti, Fabrizio

The Journal of pharmacology and experimental therapeutics, 2015-03, Vol.352 (3), p.559-567 [Periódico revisado por pares]

United States

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18
RN486, a selective Bruton's tyrosine kinase inhibitor, abrogates immune hypersensitivity responses and arthritis in rodents
RN486, a selective Bruton's tyrosine kinase inhibitor, abrogates immune hypersensitivity responses and arthritis in rodents
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RN486, a selective Bruton's tyrosine kinase inhibitor, abrogates immune hypersensitivity responses and arthritis in rodents

Xu, Daigen ; Kim, Yong ; Postelnek, Jennifer ; Vu, Minh Diem ; Hu, Dong-Qing ; Liao, Cheng ; Bradshaw, Mike ; Hsu, Jonathan ; Zhang, Jun ; Pashine, Achal ; Srinivasan, Dinesh ; Woods, John ; Levin, Anita ; O'Mahony, Alison ; Owens, Timothy D ; Lou, Yan ; Hill, Ronald J ; Narula, Satwant ; DeMartino, Julie ; Fine, Jay S

The Journal of pharmacology and experimental therapeutics, 2012-04, Vol.341 (1), p.90-103 [Periódico revisado por pares]

United States

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19
(-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol hydrochloride (tapentadol HCl): a novel mu-opioid receptor agonist/norepinephrine reuptake inhibitor with broad-spectrum analgesic properties
(-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol hydrochloride (tapentadol HCl): a novel mu-opioid receptor agonist/norepinephrine reuptake inhibitor with broad-spectrum analgesic properties
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(-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol hydrochloride (tapentadol HCl): a novel mu-opioid receptor agonist/norepinephrine reuptake inhibitor with broad-spectrum analgesic properties

Tzschentke, Thomas M ; Christoph, Thomas ; Kögel, Babette ; Schiene, Klaus ; Hennies, Hagen-Heinrich ; Englberger, Werner ; Haurand, Michael ; Jahnel, Ulrich ; Cremers, Thomas I F H ; Friderichs, Elmar ; De Vry, Jean

The Journal of pharmacology and experimental therapeutics, 2007-10, Vol.323 (1), p.265-276 [Periódico revisado por pares]

United States

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20
Specific Lowering of Asymmetric Dimethylarginine by Pharmacological Dimethylarginine Dimethylaminohydrolase Improves Endothelial Function, Reduces Blood Pressure and Ischemia-Reperfusion Injury
Specific Lowering of Asymmetric Dimethylarginine by Pharmacological Dimethylarginine Dimethylaminohydrolase Improves Endothelial Function, Reduces Blood Pressure and Ischemia-Reperfusion Injury
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Specific Lowering of Asymmetric Dimethylarginine by Pharmacological Dimethylarginine Dimethylaminohydrolase Improves Endothelial Function, Reduces Blood Pressure and Ischemia-Reperfusion Injury

Lee, Young ; Mehrotra, Purvi ; Basile, David ; Ullah, Mahbub ; Singh, Arshnoor ; Skill, Nicholas ; Younes, Subhi Talal ; Sasser, Jennifer ; Shekhar, Anantha ; Singh, Jaipal

The Journal of pharmacology and experimental therapeutics, 2021-02, Vol.376 (2), p.181-189 [Periódico revisado por pares]

United States: The American Society for Pharmacology and Experimental Therapeutics

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