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Difluoromethylbenzoxazole Pyrimidine Thioether Derivatives: A Novel Class of Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors
Difluoromethylbenzoxazole Pyrimidine Thioether Derivatives: A Novel Class of Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors
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Difluoromethylbenzoxazole Pyrimidine Thioether Derivatives: A Novel Class of Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors

Boyer, Jérémie ; Arnoult, Eric ; Médebielle, Maurice ; Guillemont, Jérôme ; Unge, Johan ; Jochmans, Dirk

Journal of medicinal chemistry, 2011-12, Vol.54 (23), p.7974-7985 [Periódico revisado por pares]

United States: American Chemical Society

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2
Disubstituted Bis-THF Moieties as New P2 Ligands in Nonpeptidal HIV‑1 Protease Inhibitors (II)
Disubstituted Bis-THF Moieties as New P2 Ligands in Nonpeptidal HIV‑1 Protease Inhibitors (II)
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Disubstituted Bis-THF Moieties as New P2 Ligands in Nonpeptidal HIV‑1 Protease Inhibitors (II)

Hohlfeld, Konrad ; Wegner, Jörg Kurt ; Kesteleyn, Bart ; Linclau, Bruno ; Unge, Johan

Journal of medicinal chemistry, 2015-05, Vol.58 (9), p.4029-4038 [Periódico revisado por pares]

United States: American Chemical Society

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3
Synthesis of P1′-Functionalized Macrocyclic Transition-State Mimicking HIV‑1 Protease Inhibitors Encompassing a Tertiary Alcohol
Synthesis of P1′-Functionalized Macrocyclic Transition-State Mimicking HIV‑1 Protease Inhibitors Encompassing a Tertiary Alcohol
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Synthesis of P1′-Functionalized Macrocyclic Transition-State Mimicking HIV‑1 Protease Inhibitors Encompassing a Tertiary Alcohol

De Rosa, Maria ; Unge, Johan ; Motwani, Hitesh V ; Rosenquist, Åsa ; Vrang, Lotta ; Wallberg, Hans ; Larhed, Mats

Journal of medicinal chemistry, 2014-08, Vol.57 (15), p.6444-6457 [Periódico revisado por pares]

United States: American Chemical Society

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4
Interaction Kinetic Characterization of HIV-1 Reverse Transcriptase Non-nucleoside Inhibitor Resistance
Interaction Kinetic Characterization of HIV-1 Reverse Transcriptase Non-nucleoside Inhibitor Resistance
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Interaction Kinetic Characterization of HIV-1 Reverse Transcriptase Non-nucleoside Inhibitor Resistance

Geitmann, Matthis ; Unge, Torsten ; Danielson, U. Helena

Journal of medicinal chemistry, 2006-04, Vol.49 (8), p.2375-2387 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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5
Discovery of (3-(4-(2-Oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone (AZD1979), a Melanin Concentrating Hormone Receptor 1 (MCHr1) Antagonist with Favorable Physicochemical Properties
Discovery of (3-(4-(2-Oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone (AZD1979), a Melanin Concentrating Hormone Receptor 1 (MCHr1) Antagonist with Favorable Physicochemical Properties
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Discovery of (3-(4-(2-Oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone (AZD1979), a Melanin Concentrating Hormone Receptor 1 (MCHr1) Antagonist with Favorable Physicochemical Properties

Johansson, Anders ; Löfberg, Christian ; Antonsson, Madeleine ; von Unge, Sverker ; Hayes, Martin A ; Judkins, Robert ; Ploj, Karolina ; Benthem, Lambertus ; Lindén, Daniel ; Brodin, Peter ; Wennerberg, Marie ; Fredenwall, Marléne ; Li, Lanna ; Persson, Joachim ; Bergman, Rolf ; Pettersen, Anna ; Gennemark, Peter ; Hogner, Anders

Journal of medicinal chemistry, 2016-03, Vol.59 (6), p.2497-2511 [Periódico revisado por pares]

United States: American Chemical Society

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6
Design and Synthesis of P1–P3 Macrocyclic Tertiary-Alcohol-Comprising HIV‑1 Protease Inhibitors
Design and Synthesis of P1–P3 Macrocyclic Tertiary-Alcohol-Comprising HIV‑1 Protease Inhibitors
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Design and Synthesis of P1–P3 Macrocyclic Tertiary-Alcohol-Comprising HIV‑1 Protease Inhibitors

Joshi, Advait ; Véron, Jean-Baptiste ; Unge, Johan ; Rosenquist, Åsa ; Wallberg, Hans ; Samuelsson, Bertil ; Hallberg, Anders ; Larhed, Mats

Journal of medicinal chemistry, 2013-11, Vol.56 (22), p.8999-9007 [Periódico revisado por pares]

United States: American Chemical Society

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7
Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Stereopure Lactam-Based HIV-1 Protease Inhibitors
Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Stereopure Lactam-Based HIV-1 Protease Inhibitors
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Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Stereopure Lactam-Based HIV-1 Protease Inhibitors

Wu, Xiongyu ; Öhrngren, Per ; Joshi, Advait A ; Trejos, Alejandro ; Persson, Magnus ; Arvela, Riina K ; Wallberg, Hans ; Vrang, Lotta ; Rosenquist, Åsa ; Samuelsson, Bertil B ; Unge, Johan ; Larhed, Mats

Journal of medicinal chemistry, 2012-03, Vol.55 (6), p.2724-2736 [Periódico revisado por pares]

United States: American Chemical Society

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8
Two-Carbon-Elongated HIV-1 Protease Inhibitors with a Tertiary-Alcohol-Containing Transition-State Mimic
Two-Carbon-Elongated HIV-1 Protease Inhibitors with a Tertiary-Alcohol-Containing Transition-State Mimic
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Two-Carbon-Elongated HIV-1 Protease Inhibitors with a Tertiary-Alcohol-Containing Transition-State Mimic

Wu, Xiongyu ; Öhrngren, Per ; Ekegren, Jenny K ; Unge, Johan ; Unge, Torsten ; Wallberg, Hans ; Samuelsson, Bertil ; Hallberg, Anders ; Larhed, Mats

Journal of medicinal chemistry, 2008-02, Vol.51 (4), p.1053-1057 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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9
Microwave-Accelerated Synthesis of P1‘-Extended HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol in the Transition-State Mimicking Scaffold
Microwave-Accelerated Synthesis of P1‘-Extended HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol in the Transition-State Mimicking Scaffold
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Microwave-Accelerated Synthesis of P1‘-Extended HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol in the Transition-State Mimicking Scaffold

Ekegren, Jenny K ; Ginman, Nina ; Johansson, Åsa ; Wallberg, Hans ; Larhed, Mats ; Samuelsson, Bertil ; Unge, Torsten ; Hallberg, Anders

Journal of medicinal chemistry, 2006-03, Vol.49 (5), p.1828-1832 [Periódico revisado por pares]

United States: American Chemical Society

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10
Design, Synthesis, and X-ray Crystallographic Studies of α-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase
Design, Synthesis, and X-ray Crystallographic Studies of α-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase
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Design, Synthesis, and X-ray Crystallographic Studies of α-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase

Andaloussi, Mounir ; Henriksson, Lena M ; Wiȩckowska, Anna ; Lindh, Martin ; Björkelid, Christofer ; Larsson, Anna M ; Suresh, Surisetti ; Iyer, Harini ; Srinivasa, Bachally R ; Bergfors, Terese ; Unge, Torsten ; Mowbray, Sherry L ; Larhed, Mats ; Jones, T. Alwyn ; Karlén, Anders

Journal of medicinal chemistry, 2011-07, Vol.54 (14), p.4964-4976 [Periódico revisado por pares]

United States: American Chemical Society

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