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Refinado por: Nome da Publicação: Journal Of Medicinal Chemistry remover assunto: Mice remover
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1
Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain exposure and broad-spectrum potency against ALK-resistant mutations
Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain exposure and broad-spectrum potency against ALK-resistant mutations
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Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain exposure and broad-spectrum potency against ALK-resistant mutations

Johnson, Ted W ; Richardson, Paul F ; Bailey, Simon ; Brooun, Alexei ; Burke, Benjamin J ; Collins, Michael R ; Cui, J Jean ; Deal, Judith G ; Deng, Ya-Li ; Dinh, Dac ; Engstrom, Lars D ; He, Mingying ; Hoffman, Jacqui ; Hoffman, Robert L ; Huang, Qinhua ; Kania, Robert S ; Kath, John C ; Lam, Hieu ; Lam, Justine L ; Le, Phuong T ; Lingardo, Laura ; Liu, Wei ; McTigue, Michele ; Palmer, Cynthia L ; Sach, Neal W ; Smeal, Tod ; Smith, Graham L ; Stewart, Albert E ; Timofeevski, Sergei ; Zhu, Huichun ; Zhu, Jinjiang ; Zou, Helen Y ; Edwards, Martin P

Journal of medicinal chemistry, 2014-06, Vol.57 (11), p.4720-4744 [Periódico revisado por pares]

United States: American Chemical Society (ACS)

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2
Novel 1-(pyridylphenyl)-1-phenyl-2-imidazolylethanols with topical antiinflammatory activity
Novel 1-(pyridylphenyl)-1-phenyl-2-imidazolylethanols with topical antiinflammatory activity
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Novel 1-(pyridylphenyl)-1-phenyl-2-imidazolylethanols with topical antiinflammatory activity

Wright, Stephen W ; Harris, Richard R ; Collins, Robert J ; Corbett, Ronald L ; Green, Alicia M ; Wadman, Eric A ; Batt, Douglas G

Journal of medicinal chemistry, 1992-08, Vol.35 (17), p.3148-3155 [Periódico revisado por pares]

WASHINGTON: American Chemical Society

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3
Cholinergic activity of acetylenic imidazoles and related compounds
Cholinergic activity of acetylenic imidazoles and related compounds
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Cholinergic activity of acetylenic imidazoles and related compounds

Moon, Malcolm W ; Chidester, Connie G ; Heier, Richard F ; Morris, Jeanette K ; Collins, R. James ; Russell, Roland R ; Francis, Jonathan W ; Sage, G. Patrick ; Sethy, Vimala H

Journal of medicinal chemistry, 1991-08, Vol.34 (8), p.2314-2327 [Periódico revisado por pares]

United States: American Chemical Society

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4
Pharmacology of some metabolites of triazolam, alprazolam, and diazepam prepared by a simple, one-step oxidation of benzodiazepines
Pharmacology of some metabolites of triazolam, alprazolam, and diazepam prepared by a simple, one-step oxidation of benzodiazepines
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Pharmacology of some metabolites of triazolam, alprazolam, and diazepam prepared by a simple, one-step oxidation of benzodiazepines

Gall, Martin ; Kamdar, B. V ; Collins, R. J

Journal of medicinal chemistry, 1978-12, Vol.21 (12), p.1290-1294 [Periódico revisado por pares]

United States: American Chemical Society

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5
Validation of Diacyl Glycerolacyltransferase I as a Novel Target for the Treatment of Obesity and Dyslipidemia Using a Potent and Selective Small Molecule Inhibitor
Validation of Diacyl Glycerolacyltransferase I as a Novel Target for the Treatment of Obesity and Dyslipidemia Using a Potent and Selective Small Molecule Inhibitor
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Validation of Diacyl Glycerolacyltransferase I as a Novel Target for the Treatment of Obesity and Dyslipidemia Using a Potent and Selective Small Molecule Inhibitor

Zhao, Gang ; Souers, Andrew J ; Voorbach, Martin ; Falls, H. Doug ; Droz, Brian ; Brodjian, Sevan ; Lau, Yau Yi ; Iyengar, Rajesh R ; Gao, Ju ; Judd, Andrew S ; Wagaw, Seble H ; Ravn, Matthew M ; Engstrom, Kenneth M ; Lynch, John K ; Mulhern, Mathew M ; Freeman, Jennifer ; Dayton, Brian D ; Wang, Xiaojun ; Grihalde, Nelson ; Fry, Dennis ; Beno, David W. A ; Marsh, Kennan C ; Su, Zhi ; Diaz, Gilbert J ; Collins, Christine A ; Sham, Hing ; Reilly, Regina M ; Brune, Michael E ; Kym, Philip R

Journal of medicinal chemistry, 2008-02, Vol.51 (3), p.380-383 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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6
Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)‑ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors
Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)‑ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors
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Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)‑ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors

Kung, Pei-Pei ; Rui, Eugene ; Bergqvist, Simon ; Bingham, Patrick ; Braganza, John ; Collins, Michael ; Cui, Mei ; Diehl, Wade ; Dinh, Dac ; Fan, Connie ; Fantin, Valeria R ; Gukasyan, Hovhannes J ; Hu, Wenyue ; Huang, Buwen ; Kephart, Susan ; Krivacic, Cody ; Kumpf, Robert A ; Li, Gary ; Maegley, Karen A ; McAlpine, Indrawan ; Nguyen, Lisa ; Ninkovic, Sacha ; Ornelas, Martha ; Ryskin, Michael ; Scales, Stephanie ; Sutton, Scott ; Tatlock, John ; Verhelle, Dominique ; Wang, Fen ; Wells, Peter ; Wythes, Martin ; Yamazaki, Shinji ; Yip, Brian ; Yu, Xiu ; Zehnder, Luke ; Zhang, Wei-Guo ; Rollins, Robert A ; Edwards, Martin

Journal of medicinal chemistry, 2016-09, Vol.59 (18), p.8306-8325 [Periódico revisado por pares]

United States: American Chemical Society

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7
Discovery of Potent, Selective, Orally Bioavailable Stearoyl-CoA Desaturase 1 Inhibitors
Discovery of Potent, Selective, Orally Bioavailable Stearoyl-CoA Desaturase 1 Inhibitors
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Discovery of Potent, Selective, Orally Bioavailable Stearoyl-CoA Desaturase 1 Inhibitors

Liu, Gang ; Lynch, John K ; Freeman, Jennifer ; Liu, Bo ; Xin, Zhili ; Zhao, Hongyu ; Serby, Michael D ; Kym, Philip R ; Suhar, Tom S ; Smith, Harriet T ; Cao, Ning ; Yang, Ruojing ; Janis, Rich S ; Krauser, Joel A ; Cepa, Steven P ; Beno, David W. A ; Sham, Hing L ; Collins, Christine A ; Surowy, Teresa K ; Camp, Heidi S

Journal of medicinal chemistry, 2007-06, Vol.50 (13), p.3086-3100 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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8
Selective Cyclooxygenase-2 Inhibitors:  Heteroaryl Modified 1,2-Diarylimidazoles Are Potent, Orally Active Antiinflammatory Agents
Selective Cyclooxygenase-2 Inhibitors:  Heteroaryl Modified 1,2-Diarylimidazoles Are Potent, Orally Active Antiinflammatory Agents
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Selective Cyclooxygenase-2 Inhibitors:  Heteroaryl Modified 1,2-Diarylimidazoles Are Potent, Orally Active Antiinflammatory Agents

Khanna, Ish K ; Yu, Yi ; Huff, Renee M ; Weier, Richard M ; Xu, Xiangdong ; Koszyk, Francis J ; Collins, Paul W ; Cogburn, J. Nita ; Isakson, Peter C ; Koboldt, Carol M ; Masferrer, Jaime L ; Perkins, William E ; Seibert, Karen ; Veenhuizen, Amy W ; Yuan, Jinhua ; Yang, Dai-Chang ; Zhang, Yan Y

Journal of medicinal chemistry, 2000-08, Vol.43 (16), p.3168-3185 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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9
Identification of 2-(4-Benzyloxyphenyl)-N- [1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-yl]acetamide, an Orally Efficacious Melanin-Concentrating Hormone Receptor 1 Antagonist for the Treatment of Obesity
Identification of 2-(4-Benzyloxyphenyl)-N- [1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-yl]acetamide, an Orally Efficacious Melanin-Concentrating Hormone Receptor 1 Antagonist for the Treatment of Obesity
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Identification of 2-(4-Benzyloxyphenyl)-N- [1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-yl]acetamide, an Orally Efficacious Melanin-Concentrating Hormone Receptor 1 Antagonist for the Treatment of Obesity

Souers, Andrew J ; Gao, Ju ; Brune, Michael ; Bush, Eugene ; Wodka, Dariusz ; Vasudevan, Anil ; Judd, Andrew S ; Mulhern, Mathew ; Brodjian, Sevan ; Dayton, Brian ; Shapiro, Robin ; Hernandez, Lisa E ; Marsh, Kennan C ; Sham, Hing L ; Collins, Christine A ; Kym, Philip R

Journal of medicinal chemistry, 2005-03, Vol.48 (5), p.1318-1321 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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10
Creating an Antibacterial with in Vivo Efficacy: Synthesis and Characterization of Potent Inhibitors of the Bacterial Cell Division Protein FtsZ with Improved Pharmaceutical Properties
Creating an Antibacterial with in Vivo Efficacy: Synthesis and Characterization of Potent Inhibitors of the Bacterial Cell Division Protein FtsZ with Improved Pharmaceutical Properties
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Creating an Antibacterial with in Vivo Efficacy: Synthesis and Characterization of Potent Inhibitors of the Bacterial Cell Division Protein FtsZ with Improved Pharmaceutical Properties

Haydon, David J ; Bennett, James M ; Brown, David ; Collins, Ian ; Galbraith, Greta ; Lancett, Paul ; Macdonald, Rebecca ; Stokes, Neil R ; Chauhan, Pramod K ; Sutariya, Jignesh K ; Nayal, Narendra ; Srivastava, Anil ; Beanland, Joy ; Hall, Robin ; Henstock, Vincent ; Noula, Caterina ; Rockley, Chris ; Czaplewski, Lloyd

Journal of medicinal chemistry, 2010-05, Vol.53 (10), p.3927-3936 [Periódico revisado por pares]

United States: American Chemical Society

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