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Refinado por: Nome da Publicação: Journal Of Medicinal Chemistry remover assunto: Pharmacology. Drug Treatments remover Mice remover
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1
Validation of Diacyl Glycerolacyltransferase I as a Novel Target for the Treatment of Obesity and Dyslipidemia Using a Potent and Selective Small Molecule Inhibitor
Validation of Diacyl Glycerolacyltransferase I as a Novel Target for the Treatment of Obesity and Dyslipidemia Using a Potent and Selective Small Molecule Inhibitor
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Validation of Diacyl Glycerolacyltransferase I as a Novel Target for the Treatment of Obesity and Dyslipidemia Using a Potent and Selective Small Molecule Inhibitor

Zhao, Gang ; Souers, Andrew J ; Voorbach, Martin ; Falls, H. Doug ; Droz, Brian ; Brodjian, Sevan ; Lau, Yau Yi ; Iyengar, Rajesh R ; Gao, Ju ; Judd, Andrew S ; Wagaw, Seble H ; Ravn, Matthew M ; Engstrom, Kenneth M ; Lynch, John K ; Mulhern, Mathew M ; Freeman, Jennifer ; Dayton, Brian D ; Wang, Xiaojun ; Grihalde, Nelson ; Fry, Dennis ; Beno, David W. A ; Marsh, Kennan C ; Su, Zhi ; Diaz, Gilbert J ; Collins, Christine A ; Sham, Hing ; Reilly, Regina M ; Brune, Michael E ; Kym, Philip R

Journal of medicinal chemistry, 2008-02, Vol.51 (3), p.380-383 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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2
Discovery of Potent, Selective, Orally Bioavailable Stearoyl-CoA Desaturase 1 Inhibitors
Discovery of Potent, Selective, Orally Bioavailable Stearoyl-CoA Desaturase 1 Inhibitors
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Discovery of Potent, Selective, Orally Bioavailable Stearoyl-CoA Desaturase 1 Inhibitors

Liu, Gang ; Lynch, John K ; Freeman, Jennifer ; Liu, Bo ; Xin, Zhili ; Zhao, Hongyu ; Serby, Michael D ; Kym, Philip R ; Suhar, Tom S ; Smith, Harriet T ; Cao, Ning ; Yang, Ruojing ; Janis, Rich S ; Krauser, Joel A ; Cepa, Steven P ; Beno, David W. A ; Sham, Hing L ; Collins, Christine A ; Surowy, Teresa K ; Camp, Heidi S

Journal of medicinal chemistry, 2007-06, Vol.50 (13), p.3086-3100 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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3
Selective Cyclooxygenase-2 Inhibitors:  Heteroaryl Modified 1,2-Diarylimidazoles Are Potent, Orally Active Antiinflammatory Agents
Selective Cyclooxygenase-2 Inhibitors:  Heteroaryl Modified 1,2-Diarylimidazoles Are Potent, Orally Active Antiinflammatory Agents
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Selective Cyclooxygenase-2 Inhibitors:  Heteroaryl Modified 1,2-Diarylimidazoles Are Potent, Orally Active Antiinflammatory Agents

Khanna, Ish K ; Yu, Yi ; Huff, Renee M ; Weier, Richard M ; Xu, Xiangdong ; Koszyk, Francis J ; Collins, Paul W ; Cogburn, J. Nita ; Isakson, Peter C ; Koboldt, Carol M ; Masferrer, Jaime L ; Perkins, William E ; Seibert, Karen ; Veenhuizen, Amy W ; Yuan, Jinhua ; Yang, Dai-Chang ; Zhang, Yan Y

Journal of medicinal chemistry, 2000-08, Vol.43 (16), p.3168-3185 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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4
Identification of 2-(4-Benzyloxyphenyl)-N- [1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-yl]acetamide, an Orally Efficacious Melanin-Concentrating Hormone Receptor 1 Antagonist for the Treatment of Obesity
Identification of 2-(4-Benzyloxyphenyl)-N- [1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-yl]acetamide, an Orally Efficacious Melanin-Concentrating Hormone Receptor 1 Antagonist for the Treatment of Obesity
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Identification of 2-(4-Benzyloxyphenyl)-N- [1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-yl]acetamide, an Orally Efficacious Melanin-Concentrating Hormone Receptor 1 Antagonist for the Treatment of Obesity

Souers, Andrew J ; Gao, Ju ; Brune, Michael ; Bush, Eugene ; Wodka, Dariusz ; Vasudevan, Anil ; Judd, Andrew S ; Mulhern, Mathew ; Brodjian, Sevan ; Dayton, Brian ; Shapiro, Robin ; Hernandez, Lisa E ; Marsh, Kennan C ; Sham, Hing L ; Collins, Christine A ; Kym, Philip R

Journal of medicinal chemistry, 2005-03, Vol.48 (5), p.1318-1321 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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5
1,2-Diarylimidazoles as Potent, Cyclooxygenase-2 Selective, and Orally Active Antiinflammatory Agents
1,2-Diarylimidazoles as Potent, Cyclooxygenase-2 Selective, and Orally Active Antiinflammatory Agents
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1,2-Diarylimidazoles as Potent, Cyclooxygenase-2 Selective, and Orally Active Antiinflammatory Agents

Khanna, Ish K ; Weier, Richard M ; Yu, Yi ; Xu, Xiang D ; Koszyk, Francis J ; Collins, Paul W ; Koboldt, Carol M ; Veenhuizen, Amy W ; Perkins, William E ; Casler, Jacquelen J ; Masferrer, Jaime L ; Zhang, Yan Y ; Gregory, Susan A ; Seibert, Karen ; Isakson, Peter C

Journal of medicinal chemistry, 1997-05, Vol.40 (11), p.1634-1647 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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6
(1S,2S)-1-(4-Hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: A Potent New Neuroprotectant Which Blocks N-Methyl-D-Aspartate Responses
(1S,2S)-1-(4-Hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: A Potent New Neuroprotectant Which Blocks N-Methyl-D-Aspartate Responses
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(1S,2S)-1-(4-Hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: A Potent New Neuroprotectant Which Blocks N-Methyl-D-Aspartate Responses

Chenard, B. L ; Bordner, J ; Butler, T. W ; Chambers, L. K ; Collins, M. A ; De Costa, D. L ; Ducat, M. F ; Dumont, M. L ; Fox, C. B

Journal of medicinal chemistry, 1995-08, Vol.38 (16), p.3138-3145 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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7
Identification of 4-(4-Aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as Selective Inhibitors of Protein Kinase B through Fragment Elaboration
Identification of 4-(4-Aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as Selective Inhibitors of Protein Kinase B through Fragment Elaboration
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Identification of 4-(4-Aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as Selective Inhibitors of Protein Kinase B through Fragment Elaboration

Caldwell, John J ; Davies, Thomas G ; Donald, Alastair ; McHardy, Tatiana ; Rowlands, Martin G ; Aherne, G. Wynne ; Hunter, Lisa K ; Taylor, Kevin ; Ruddle, Ruth ; Raynaud, Florence I ; Verdonk, Marcel ; Workman, Paul ; Garrett, Michelle D ; Collins, Ian

Journal of medicinal chemistry, 2008-04, Vol.51 (7), p.2147-2157 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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8
Screening for Cardiovascular Safety:  A Structure−Activity Approach for Guiding Lead Selection of Melanin Concentrating Hormone Receptor 1 Antagonists
Screening for Cardiovascular Safety:  A Structure−Activity Approach for Guiding Lead Selection of Melanin Concentrating Hormone Receptor 1 Antagonists
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Screening for Cardiovascular Safety:  A Structure−Activity Approach for Guiding Lead Selection of Melanin Concentrating Hormone Receptor 1 Antagonists

Kym, Philip R ; Souers, Andrew J ; Campbell, Thomas J ; Lynch, John K ; Judd, Andrew S ; Iyengar, Rajesh ; Vasudevan, Anil ; Gao, Ju ; Freeman, Jennifer C ; Wodka, Dariusz ; Mulhern, Mathew ; Zhao, Gang ; Wagaw, Seble H ; Napier, James J ; Brodjian, Sevan ; Dayton, Brian D ; Reilly, Regina M ; Segreti, Jason A ; Fryer, Ryan M ; Preusser, Lee C ; Reinhart, Glenn A ; Hernandez, Lisa ; Marsh, Kennan C ; Sham, Hing L ; Collins, Christine A ; Polakowski, James S

Journal of medicinal chemistry, 2006-04, Vol.49 (7), p.2339-2352 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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9
Optimization of Chromone-2-carboxamide Melanin Concentrating Hormone Receptor 1 Antagonists:  Assessment of Potency, Efficacy, and Cardiovascular Safety
Optimization of Chromone-2-carboxamide Melanin Concentrating Hormone Receptor 1 Antagonists:  Assessment of Potency, Efficacy, and Cardiovascular Safety
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Optimization of Chromone-2-carboxamide Melanin Concentrating Hormone Receptor 1 Antagonists:  Assessment of Potency, Efficacy, and Cardiovascular Safety

Lynch, John K ; Freeman, Jennifer C ; Judd, Andrew S ; Iyengar, Rajesh ; Mulhern, Mathew ; Zhao, Gang ; Napier, James J ; Wodka, Dariusz ; Brodjian, Sevan ; Dayton, Brian D ; Falls, Doug ; Ogiela, Christopher ; Reilly, Regina M ; Campbell, Thomas J ; Polakowski, James S ; Hernandez, Lisa ; Marsh, Kennan C ; Shapiro, Robin ; Knourek-Segel, Victoria ; Droz, Brian ; Bush, Eugene ; Brune, Michael ; Preusser, Lee C ; Fryer, Ryan M ; Reinhart, Glenn A ; Houseman, Kathryn ; Diaz, Gilbert ; Mikhail, Ann ; Limberis, James T ; Sham, Hing L ; Collins, Christine A ; Kym, Philip R

Journal of medicinal chemistry, 2006-11, Vol.49 (22), p.6569-6584 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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10
Discovery and Characterization of Aminopiperidinecoumarin Melanin Concentrating Hormone Receptor 1 Antagonists
Discovery and Characterization of Aminopiperidinecoumarin Melanin Concentrating Hormone Receptor 1 Antagonists
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Discovery and Characterization of Aminopiperidinecoumarin Melanin Concentrating Hormone Receptor 1 Antagonists

Kym, Philip R ; Iyengar, Rajesh ; Souers, Andrew J ; Lynch, John K ; Judd, Andrew S ; Gao, Ju ; Freeman, Jennifer ; Mulhern, Mathew ; Zhao, Gang ; Vasudevan, Anil ; Wodka, Dariusz ; Blackburn, Christopher ; Brown, Jim ; Che, Jennifer Lee ; Cullis, Courtney ; Lai, Su Jen ; LaMarche, Matthew J ; Marsilje, Tom ; Roses, Jon ; Sells, Todd ; Geddes, Brad ; Govek, Elizabeth ; Patane, Michael ; Fry, Dennis ; Dayton, Brian D ; Brodjian, Sevan ; Falls, Doug ; Brune, Michael ; Bush, Eugene ; Shapiro, Robin ; Knourek-Segel, Victoria ; Fey, Thomas ; McDowell, Cathleen ; Reinhart, Glenn A ; Preusser, Lee C ; Marsh, Kennan ; Hernandez, Lisa ; Sham, Hing L ; Collins, Christine A

Journal of medicinal chemistry, 2005-09, Vol.48 (19), p.5888-5891 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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