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Predicting protein ligand binding sites by combining evolutionary sequence conservation and 3D structure
Predicting protein ligand binding sites by combining evolutionary sequence conservation and 3D structure
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Predicting protein ligand binding sites by combining evolutionary sequence conservation and 3D structure

Capra, John A ; Laskowski, Roman A ; Thornton, Janet M ; Singh, Mona ; Funkhouser, Thomas A Lengauer, Thomas

PLoS computational biology, 2009-12, Vol.5 (12), p.e1000585 [Periódico revisado por pares]

United States: Public Library of Science

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2
PoreWalker: a novel tool for the identification and characterization of channels in transmembrane proteins from their three-dimensional structure
PoreWalker: a novel tool for the identification and characterization of channels in transmembrane proteins from their three-dimensional structure
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PoreWalker: a novel tool for the identification and characterization of channels in transmembrane proteins from their three-dimensional structure

Pellegrini-Calace, Marialuisa ; Maiwald, Tim ; Thornton, Janet M Lengauer, Thomas

PLoS computational biology, 2009-07, Vol.5 (7), p.e1000440-e1000440 [Periódico revisado por pares]

United States: Public Library of Science

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3
Using the drug-protein interactome to identify anti-ageing compounds for humans
Using the drug-protein interactome to identify anti-ageing compounds for humans
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Using the drug-protein interactome to identify anti-ageing compounds for humans

Fuentealba, Matías ; Dönertaş, Handan Melike ; Williams, Rhianna ; Labbadia, Johnathan ; Thornton, Janet M ; Partridge, Linda Iakoucheva, Lilia M.

PLoS computational biology, 2019-01, Vol.15 (1), p.e1006639-e1006639 [Periódico revisado por pares]

United States: Public Library of Science

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4
Amino acid changes in disease-associated variants differ radically from variants observed in the 1000 genomes project dataset
Amino acid changes in disease-associated variants differ radically from variants observed in the 1000 genomes project dataset
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Amino acid changes in disease-associated variants differ radically from variants observed in the 1000 genomes project dataset

de Beer, Tjaart A P ; Laskowski, Roman A ; Parks, Sarah L ; Sipos, Botond ; Goldman, Nick ; Thornton, Janet M Bromberg, Yana

PLoS computational biology, 2013-12, Vol.9 (12), p.e1003382-e1003382 [Periódico revisado por pares]

United States: Public Library of Science

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5
DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans
DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans
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DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans

Tullet, Jennifer M A ; Araiz, Caroline ; Sanders, Matthew J ; Au, Catherine ; Benedetto, Alexandre ; Papatheodorou, Irene ; Clark, Emily ; Schmeisser, Kathrin ; Jones, Daniel ; Schuster, Eugene F ; Thornton, Janet M ; Gems, David Kim, Stuart K.

PLoS genetics, 2014-02, Vol.10 (2), p.e1004109-e1004109 [Periódico revisado por pares]

United States: Public Library of Science

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6
A computational and structural analysis of germline and somatic variants affecting the DDR mechanism, and their impact on human diseases
A computational and structural analysis of germline and somatic variants affecting the DDR mechanism, and their impact on human diseases
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A computational and structural analysis of germline and somatic variants affecting the DDR mechanism, and their impact on human diseases

Magraner-Pardo, Lorena ; Laskowski, Roman A ; Pons, Tirso ; Thornton, Janet M

Scientific reports, 2021-07, Vol.11 (1), p.14268-14268, Article 14268 [Periódico revisado por pares]

England: Nature Publishing Group

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7
Comparisons of Allergenic and Metazoan Parasite Proteins: Allergy the Price of Immunity
Comparisons of Allergenic and Metazoan Parasite Proteins: Allergy the Price of Immunity
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Comparisons of Allergenic and Metazoan Parasite Proteins: Allergy the Price of Immunity

Tyagi, Nidhi ; Farnell, Edward J ; Fitzsimmons, Colin M ; Ryan, Stephanie ; Tukahebwa, Edridah ; Maizels, Rick M ; Dunne, David W ; Thornton, Janet M ; Furnham, Nicholas Antia, Rustom

PLoS computational biology, 2015-10, Vol.11 (10), p.e1004546 [Periódico revisado por pares]

United States: Public Library of Science

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8
Exploring the evolution of novel enzyme functions within structurally defined protein superfamilies
Exploring the evolution of novel enzyme functions within structurally defined protein superfamilies
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Exploring the evolution of novel enzyme functions within structurally defined protein superfamilies

Furnham, Nicholas ; Sillitoe, Ian ; Holliday, Gemma L ; Cuff, Alison L ; Laskowski, Roman A ; Orengo, Christine A ; Thornton, Janet M Ofran, Yanay

PLoS computational biology, 2012-03, Vol.8 (3), p.e1002403-e1002403 [Periódico revisado por pares]

United States: Public Library of Science

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9
Data-driven identification of ageing-related diseases from electronic health records
Data-driven identification of ageing-related diseases from electronic health records
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Data-driven identification of ageing-related diseases from electronic health records

Kuan, Valerie ; Fraser, Helen C ; Hingorani, Melanie ; Denaxas, Spiros ; Gonzalez-Izquierdo, Arturo ; Direk, Kenan ; Nitsch, Dorothea ; Mathur, Rohini ; Parisinos, Constantinos A ; Lumbers, R Thomas ; Sofat, Reecha ; Wong, Ian C K ; Casas, Juan P ; Thornton, Janet M ; Hemingway, Harry ; Partridge, Linda ; Hingorani, Aroon D

Scientific reports, 2021-02, Vol.11 (1), p.2938-2938, Article 2938 [Periódico revisado por pares]

England: Nature Publishing Group

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10
Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity
Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity
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Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity

Bolukbasi, Ekin ; Khericha, Mobina ; Regan, Jennifer C. ; Ivanov, Dobril K. ; Adcott, Jennifer ; Dyson, Miranda C. ; Nespital, Tobias ; Thornton, Janet M. ; Alic, Nazif ; Partridge, Linda

Cell reports (Cambridge), 2017-10, Vol.21 (3), p.641-653 [Periódico revisado por pares]

United States: Elsevier Inc

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