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Refinado por: Nome da Publicação: Journal Of Medicinal Chemistry remover assunto: Science & Technology remover
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11
Structure−Activity Studies of 6-Substituted Decahydroisoquinoline-3-carboxylic Acid AMPA Receptor Antagonists. 2. Effects of Distal Acid Bioisosteric Substitution, Absolute Stereochemical Preferences, and in Vivo Activity
Structure−Activity Studies of 6-Substituted Decahydroisoquinoline-3-carboxylic Acid AMPA Receptor Antagonists. 2. Effects of Distal Acid Bioisosteric Substitution, Absolute Stereochemical Preferences, and in Vivo Activity
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Structure−Activity Studies of 6-Substituted Decahydroisoquinoline-3-carboxylic Acid AMPA Receptor Antagonists. 2. Effects of Distal Acid Bioisosteric Substitution, Absolute Stereochemical Preferences, and in Vivo Activity

Ornstein, Paul L ; Arnold, M. Brian ; Allen, Nancy K ; Bleisch, Thomas ; Borromeo, Peter S ; Lugar, Charles W ; Leander, J. David ; Lodge, David ; Schoepp, Darryle D

Journal of medicinal chemistry, 1996-05, Vol.39 (11), p.2232-2244 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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12
Ethyl (3S,4aR,6S,8aR)-6-(4-Ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso- quinoline-3-carboxylic Ester:  A Prodrug of a GluR5 Kainate Receptor Antagonist Active in Two Animal Models of Acute Migraine
Ethyl (3S,4aR,6S,8aR)-6-(4-Ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso- quinoline-3-carboxylic Ester:  A Prodrug of a GluR5 Kainate Receptor Antagonist Active in Two Animal Models of Acute Migraine
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Ethyl (3S,4aR,6S,8aR)-6-(4-Ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso- quinoline-3-carboxylic Ester:  A Prodrug of a GluR5 Kainate Receptor Antagonist Active in Two Animal Models of Acute Migraine

Filla, Sandra A ; Winter, Mark A ; Johnson, Kirk W ; Bleakman, David ; Bell, Michael G ; Bleisch, Thomas J ; Castaño, Ana M ; Clemens-Smith, Amy ; del Prado, Miriam ; Dieckman, Donna K ; Dominguez, Esteban ; Escribano, Ana ; Ho, Ken H ; Hudziak, Kevin J ; Katofiasc, Mary A ; Martinez-Perez, Jose A ; Mateo, Ana ; Mathes, Brian M ; Mattiuz, Edward L ; Ogden, Ann Marie L ; Phebus, Lee A ; Stack, Douglas R ; Stratford, Robert E ; Ornstein, Paul L

Journal of medicinal chemistry, 2002-09, Vol.45 (20), p.4383-4386 [Periódico revisado por pares]

United States: American Chemical Society

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13
6-Substituted decahydroisoquinoline-3-carboxylic acids as potent and selective conformationally constrained NMDA receptor antagonists
6-Substituted decahydroisoquinoline-3-carboxylic acids as potent and selective conformationally constrained NMDA receptor antagonists
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6-Substituted decahydroisoquinoline-3-carboxylic acids as potent and selective conformationally constrained NMDA receptor antagonists

Ornstein, Paul L ; Schoepp, Darryle D ; Arnold, M. Brian ; Augenstein, Nancy K ; Lodge, David ; Millar, John D ; Chambers, John ; Campbell, Jack ; Paschal, Jonathan W

Journal of medicinal chemistry, 1992-09, Vol.35 (19), p.3547-3560 [Periódico revisado por pares]

WASHINGTON: American Chemical Society

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14
4-(Tetrazolylalkyl)piperidine-2-carboxylic acids. Potent and selective N-methyl-D-aspartic acid receptor antagonists with a short duration of action
4-(Tetrazolylalkyl)piperidine-2-carboxylic acids. Potent and selective N-methyl-D-aspartic acid receptor antagonists with a short duration of action
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4-(Tetrazolylalkyl)piperidine-2-carboxylic acids. Potent and selective N-methyl-D-aspartic acid receptor antagonists with a short duration of action

Ornstein, Paul L ; Schoepp, Darryle D ; Arnold, M. Brian ; Leander, J. David ; Lodge, David ; Paschal, Jonathan W ; Elzey, Tom

Journal of medicinal chemistry, 1991-01, Vol.34 (1), p.90-97 [Periódico revisado por pares]

United States: American Chemical Society

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15
Synthesis and excitatory amino acid pharmacology of a series of heterocyclic-fused quinoxalinones and quinazolinones
Synthesis and excitatory amino acid pharmacology of a series of heterocyclic-fused quinoxalinones and quinazolinones
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Synthesis and excitatory amino acid pharmacology of a series of heterocyclic-fused quinoxalinones and quinazolinones

McQuaid, Loretta A ; Smith, Edward C. R ; South, Kimberly K ; Mitch, Charles H ; Schoepp, Darryle D ; True, Rebecca A ; Calligaro, David O ; O'Malley, Patrick J ; Lodge, David ; Ornstein, Paul L

Journal of medicinal chemistry, 1992-09, Vol.35 (18), p.3319-3324 [Periódico revisado por pares]

WASHINGTON: American Chemical Society

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16
(3SR,4aRS,6SR,8aRS)-6-(1H-Tetrazol-5-yl)decahydroisoquinoline-3-carboxylic Acid, a Novel, Competitive, Systemically Active NMDA and AMPA Receptor Antagonist
(3SR,4aRS,6SR,8aRS)-6-(1H-Tetrazol-5-yl)decahydroisoquinoline-3-carboxylic Acid, a Novel, Competitive, Systemically Active NMDA and AMPA Receptor Antagonist
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(3SR,4aRS,6SR,8aRS)-6-(1H-Tetrazol-5-yl)decahydroisoquinoline-3-carboxylic Acid, a Novel, Competitive, Systemically Active NMDA and AMPA Receptor Antagonist

Ornstein, Paul L ; Arnold, M. Brian ; Allen, Nancy K ; Leander, J. David ; Tizzano, Joseph P ; Lodge, David ; Schoepp, Darryle D

Journal of medicinal chemistry, 1995-12, Vol.38 (25), p.4885-4890 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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17
Analogs of the dioxolanes dexoxadrol and etoxadrol as potential phencyclidine-like agents. Synthesis and structure activity relationships
Analogs of the dioxolanes dexoxadrol and etoxadrol as potential phencyclidine-like agents. Synthesis and structure activity relationships
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Analogs of the dioxolanes dexoxadrol and etoxadrol as potential phencyclidine-like agents. Synthesis and structure activity relationships

Thurkauf, Andrew ; Mattson, Mariena V ; Richardson, Scott ; Mirsadeghi, Seid ; Ornstein, Paul L ; Harrison, Ernest A ; Rice, Kenner C ; Jacobson, Arthur E ; Monn, James A

Journal of medicinal chemistry, 1992-04, Vol.35 (8), p.1323-1329 [Periódico revisado por pares]

WASHINGTON: American Chemical Society

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18
NMDA ANTAGONIST ACTIVITY OF (+/-)-(2SR,4RS)-4-(1H-TETRAZOL-5-YLMETHYL)PIPERIDINE-2-CARBOXYLIC ACID RESIDES WITH THE (-)-2R,4S-ISOMER
NMDA ANTAGONIST ACTIVITY OF (+/-)-(2SR,4RS)-4-(1H-TETRAZOL-5-YLMETHYL)PIPERIDINE-2-CARBOXYLIC ACID RESIDES WITH THE (-)-2R,4S-ISOMER
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NMDA ANTAGONIST ACTIVITY OF (+/-)-(2SR,4RS)-4-(1H-TETRAZOL-5-YLMETHYL)PIPERIDINE-2-CARBOXYLIC ACID RESIDES WITH THE (-)-2R,4S-ISOMER

ORNSTEIN, PL ; SCHOEPP, DD ; ARNOLD, MB ; JONES, ND ; DEETER, JB ; LODGE, D ; LEANDER, JD

Journal of medicinal chemistry, 1992-08, Vol.35 (17), p.3111-3115 [Periódico revisado por pares]

WASHINGTON: Amer Chemical Soc

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