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1
Synthesis and Evaluation of a Series of Novel 2-[(4-Chlorophenoxy)methyl]- benzimidazoles as Selective Neuropeptide Y Y1 Receptor Antagonists
Synthesis and Evaluation of a Series of Novel 2-[(4-Chlorophenoxy)methyl]- benzimidazoles as Selective Neuropeptide Y Y1 Receptor Antagonists
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Synthesis and Evaluation of a Series of Novel 2-[(4-Chlorophenoxy)methyl]- benzimidazoles as Selective Neuropeptide Y Y1 Receptor Antagonists

Zarrinmayeh, Hamideh ; Nunes, Anne M ; Ornstein, Paul L ; Zimmerman, Dennis M ; Arnold, M. Brian ; Schober, Douglas A ; Gackenheimer, Susan L ; Bruns, Robert F ; Hipskind, Philip A ; Britton, Thomas C ; Cantrell, Buddy E ; Gehlert, Donald R

Journal of medicinal chemistry, 1998-07, Vol.41 (15), p.2709-2719 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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2
Biarylpropylsulfonamides as Novel, Potent Potentiators of 2-Amino-3- (5-methyl-3-hydroxyisoxazol-4-yl)- propanoic Acid (AMPA) Receptors
Biarylpropylsulfonamides as Novel, Potent Potentiators of 2-Amino-3- (5-methyl-3-hydroxyisoxazol-4-yl)- propanoic Acid (AMPA) Receptors
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Biarylpropylsulfonamides as Novel, Potent Potentiators of 2-Amino-3- (5-methyl-3-hydroxyisoxazol-4-yl)- propanoic Acid (AMPA) Receptors

Ornstein, Paul L ; Zimmerman, Dennis M ; Arnold, M. Brian ; Bleisch, Thomas J ; Cantrell, Buddy ; Simon, Richard ; Zarrinmayeh, Hamideh ; Baker, S. Richard ; Gates, Mary ; Tizzano, Joseph P ; Bleakman, David ; Mandelzys, Allan ; Jarvie, Kieth R ; Ho, Ken ; Deverill, Michelle ; Kamboj, Rajender K

Journal of medicinal chemistry, 2000-11, Vol.43 (23), p.4354-4358 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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3
2-Substituted (2SR)-2-Amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 2. Effects of Aromatic Substitution, Pharmacological Characterization, and Bioavailability
2-Substituted (2SR)-2-Amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 2. Effects of Aromatic Substitution, Pharmacological Characterization, and Bioavailability
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2-Substituted (2SR)-2-Amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 2. Effects of Aromatic Substitution, Pharmacological Characterization, and Bioavailability

Ornstein, Paul L ; Bleisch, Thomas J ; Arnold, M. Brian ; Kennedy, Joseph H ; Wright, Rebecca A ; Johnson, Bryan G ; Tizzano, Joseph P ; Helton, David R ; Kallman, Mary Jeanne ; Schoepp, Darryle D ; Hérin, Marc

Journal of medicinal chemistry, 1998-01, Vol.41 (3), p.358-378 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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4
2-Substituted (2SR)-2-Amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 1. Effects of Alkyl, Arylalkyl, and Diarylalkyl Substitution
2-Substituted (2SR)-2-Amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 1. Effects of Alkyl, Arylalkyl, and Diarylalkyl Substitution
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2-Substituted (2SR)-2-Amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 1. Effects of Alkyl, Arylalkyl, and Diarylalkyl Substitution

Ornstein, Paul L ; Bleisch, Thomas J ; Arnold, M. Brian ; Wright, Rebecca A ; Johnson, Bryan G ; Schoepp, Darryle D

Journal of medicinal chemistry, 1998-01, Vol.41 (3), p.346-357 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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5
Synthesis and Structure−Activity Relationships of Novel Arylpiperazines as Potent and Selective Agonists of the Melanocortin Subtype-4 Receptor
Synthesis and Structure−Activity Relationships of Novel Arylpiperazines as Potent and Selective Agonists of the Melanocortin Subtype-4 Receptor
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Synthesis and Structure−Activity Relationships of Novel Arylpiperazines as Potent and Selective Agonists of the Melanocortin Subtype-4 Receptor

Richardson, Timothy I ; Ornstein, Paul L ; Briner, Karin ; Fisher, Matthew J ; Backer, Ryan T ; Biggers, C. Kelly ; Clay, Michael P ; Emmerson, Paul J ; Hertel, Larry W ; Hsiung, Hansen M ; Husain, Saba ; Kahl, Steven D ; Lee, Jonathan A ; Lindstrom, Terry D ; Martinelli, Michael J ; Mayer, John P ; Mullaney, Jeffery T ; O'Brien, Thomas P ; Pawlak, Joseph M ; Revell, Kevin D ; Shah, Jikesh ; Zgombick, John M ; Herr, R. Jason ; Melekhov, Alex ; Sampson, Peter B ; King, Chi-Hsin R

Journal of medicinal chemistry, 2004-01, Vol.47 (3), p.744-755 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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6
Structure−Activity Studies of 6-(Tetrazolylalkyl)-Substituted Decahydroisoquinoline-3-carboxylic Acid AMPA Receptor Antagonists. 1. Effects of Stereochemistry, Chain Length, and Chain Substitution
Structure−Activity Studies of 6-(Tetrazolylalkyl)-Substituted Decahydroisoquinoline-3-carboxylic Acid AMPA Receptor Antagonists. 1. Effects of Stereochemistry, Chain Length, and Chain Substitution
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Structure−Activity Studies of 6-(Tetrazolylalkyl)-Substituted Decahydroisoquinoline-3-carboxylic Acid AMPA Receptor Antagonists. 1. Effects of Stereochemistry, Chain Length, and Chain Substitution

Ornstein, Paul L ; Arnold, M. Brian ; Allen, Nancy K ; Bleisch, Thomas ; Borromeo, Peter S ; Lugar, Charles W ; Leander, J. David ; Lodge, David ; Schoepp, Darryle D

Journal of medicinal chemistry, 1996-05, Vol.39 (11), p.2219-2231 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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7
Structure−Activity Studies of 6-Substituted Decahydroisoquinoline-3-carboxylic Acid AMPA Receptor Antagonists. 2. Effects of Distal Acid Bioisosteric Substitution, Absolute Stereochemical Preferences, and in Vivo Activity
Structure−Activity Studies of 6-Substituted Decahydroisoquinoline-3-carboxylic Acid AMPA Receptor Antagonists. 2. Effects of Distal Acid Bioisosteric Substitution, Absolute Stereochemical Preferences, and in Vivo Activity
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Structure−Activity Studies of 6-Substituted Decahydroisoquinoline-3-carboxylic Acid AMPA Receptor Antagonists. 2. Effects of Distal Acid Bioisosteric Substitution, Absolute Stereochemical Preferences, and in Vivo Activity

Ornstein, Paul L ; Arnold, M. Brian ; Allen, Nancy K ; Bleisch, Thomas ; Borromeo, Peter S ; Lugar, Charles W ; Leander, J. David ; Lodge, David ; Schoepp, Darryle D

Journal of medicinal chemistry, 1996-05, Vol.39 (11), p.2232-2244 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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8
(3SR,4aRS,6SR,8aRS)-6-(1H-Tetrazol-5-yl)decahydroisoquinoline-3-carboxylic Acid, a Novel, Competitive, Systemically Active NMDA and AMPA Receptor Antagonist
(3SR,4aRS,6SR,8aRS)-6-(1H-Tetrazol-5-yl)decahydroisoquinoline-3-carboxylic Acid, a Novel, Competitive, Systemically Active NMDA and AMPA Receptor Antagonist
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(3SR,4aRS,6SR,8aRS)-6-(1H-Tetrazol-5-yl)decahydroisoquinoline-3-carboxylic Acid, a Novel, Competitive, Systemically Active NMDA and AMPA Receptor Antagonist

Ornstein, Paul L ; Arnold, M. Brian ; Allen, Nancy K ; Leander, J. David ; Tizzano, Joseph P ; Lodge, David ; Schoepp, Darryle D

Journal of medicinal chemistry, 1995-12, Vol.38 (25), p.4885-4890 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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