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The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsyGunthorpe, Martin J. ; Large, Charles H. ; Sankar, RamanEpilepsia (Copenhagen), 2012-03, Vol.53 (3), p.412-424 [Periódico revisado por pares]Oxford, UK: Blackwell Publishing LtdTexto completo disponível |
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Angiotensin-Converting Enzyme 2–Independent Action of Presumed Angiotensin-Converting Enzyme 2 Activators: Studies In Vivo, Ex Vivo, and In VitroHaber, Philipp K ; Ye, Minghao ; Wysocki, Jan ; Maier, Christoph ; Haque, Syed K ; Batlle, DanielHypertension (Dallas, Tex. 1979), 2014-04, Vol.63 (4), p.774-782 [Periódico revisado por pares]Hagerstown, MD: American Heart Association, IncTexto completo disponível |
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Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I : A Mechanism for the Action of Berberine to Activate AMP-Activated Protein Kinase and Improve Insulin ActionTURNER, Nigel ; LI, Jing-Ya ; HU, Li-Hong ; JIA LI ; YE, Ji-Ming ; GOSBY, Alison ; TO, Sabrina W. C ; ZHE CHENG ; MIYOSHI, Hiroyuki ; TAKETO, Makoto M ; COONEY, Gregory J ; KRAEGEN, Edward W ; JAMES, David EDiabetes (New York, N.Y.), 2008-05, Vol.57 (5), p.1414-1418 [Periódico revisado por pares]Alexandria, VA: American Diabetes AssociationTexto completo disponível |
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Material Type: Artigo
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Mechanisms of Lidocaine’s Action on Subtypes of Spinal Dorsal Horn Neurons Subject to the Diverse Roles of Na+ and K+ Channels in Action Potential GenerationWolff, Matthias ; Schnöbel-Ehehalt, Rose ; Mühling, Jörg ; Weigand, Markus A ; Olschewski, AndreaAnesthesia and analgesia, 2014-08, Vol.119 (2), p.463-470 [Periódico revisado por pares]United States: International Anesthesia Research SocietyTexto completo disponível |
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Material Type: Artigo
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TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid actionGao, Yuan ; Cao, Erhu ; Julius, David ; Cheng, YifanNature (London), 2016-06, Vol.534 (7607), p.347-351 [Periódico revisado por pares]England: Nature Publishing GroupTexto completo disponível |
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Material Type: Artigo
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Real‐time characterization of cannabinoid receptor 1 (CB1) allosteric modulators reveals novel mechanism of actionCawston, Erin E ; Redmond, William J ; Breen, Courtney M ; Grimsey, Natasha L ; Connor, Mark ; Glass, MichelleBritish journal of pharmacology, 2013-10, Vol.170 (4), p.893-907 [Periódico revisado por pares]England: Blackwell Publishing LtdTexto completo disponível |
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Material Type: Artigo
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Brivaracetam, a selective high‐affinity synaptic vesicle protein 2A (SV2A) ligand with preclinical evidence of high brain permeability and fast onset of actionNicolas, Jean‐Marie ; Hannestad, Jonas ; Holden, Daniel ; Kervyn, Sophie ; Nabulsi, Nabeel ; Tytgat, Dominique ; Huang, Yiyun ; Chanteux, Hugues ; Staelens, Ludovicus ; Matagne, Alain ; Mathy, François‐Xavier ; Mercier, Joël ; Stockis, Armel ; Carson, Richard E. ; Klitgaard, HenrikEpilepsia (Copenhagen), 2016-02, Vol.57 (2), p.201-209 [Periódico revisado por pares]United States: Wiley Subscription Services, IncTexto completo disponível |
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Material Type: Artigo
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Incretin Action in the Pancreas: Potential Promise, Possible Perils, and Pathological PitfallsDRUCKER, Daniel JDiabetes (New York, N.Y.), 2013-10, Vol.62 (10), p.3316-3323 [Periódico revisado por pares]Alexandria, VA: American Diabetes AssociationTexto completo disponível |
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Material Type: Artigo
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Action-Potential Modulation During Axonal ConductionSasaki, Takuya ; Matsuki, Norio ; Ikegaya, YujiScience (American Association for the Advancement of Science), 2011-02, Vol.331 (6017), p.599-601 [Periódico revisado por pares]Washington, DC: American Association for the Advancement of ScienceTexto completo disponível |
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Material Type: Artigo
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Editorial for “USPIO‐SWI Shows Fingolimod Enhanced Alteplase Action on Angiographic Reperfusion in eMCAO Rats”Bergen, Tatyana A. ; Shestov, Alexander A.Journal of magnetic resonance imaging, 2022-04, Vol.55 (4), p.1107-1108 [Periódico revisado por pares]Hoboken, USA: John Wiley & Sons, IncTexto completo disponível |