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Refinado por: assunto: Structure-Activity Relationship remover
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1
Structure-based discovery of opioid analgesics with reduced side effects
Structure-based discovery of opioid analgesics with reduced side effects
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Structure-based discovery of opioid analgesics with reduced side effects

Manglik, Aashish ; Lin, Henry ; Aryal, Dipendra K ; McCorvy, John D ; Dengler, Daniela ; Corder, Gregory ; Levit, Anat ; Kling, Ralf C ; Bernat, Viachaslau ; Hübner, Harald ; Huang, Xi-Ping ; Sassano, Maria F ; Giguère, Patrick M ; Löber, Stefan ; Da Duan ; Scherrer, Grégory ; Kobilka, Brian K ; Gmeiner, Peter ; Roth, Bryan L ; Shoichet, Brian K

Nature (London), 2016-09, Vol.537 (7619), p.185-190 [Periódico revisado por pares]

England: Nature Publishing Group

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2
Nociceptin Opioid Receptor (NOP) as a Therapeutic Target: Progress in Translation from Preclinical Research to Clinical Utility
Nociceptin Opioid Receptor (NOP) as a Therapeutic Target: Progress in Translation from Preclinical Research to Clinical Utility
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Nociceptin Opioid Receptor (NOP) as a Therapeutic Target: Progress in Translation from Preclinical Research to Clinical Utility

Zaveri, Nurulain T

Journal of medicinal chemistry, 2016-08, Vol.59 (15), p.7011-7028 [Periódico revisado por pares]

United States

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3
The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides
The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides
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The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides

Meyrath, Max ; Szpakowska, Martyna ; Zeiner, Julian ; Massotte, Laurent ; Merz, Myriam P ; Benkel, Tobias ; Simon, Katharina ; Ohnmacht, Jochen ; Turner, Jonathan D ; Krüger, Rejko ; Seutin, Vincent ; Ollert, Markus ; Kostenis, Evi ; Chevigné, Andy

Nature communications, 2020-06, Vol.11 (1), p.3033-3033, Article 3033 [Periódico revisado por pares]

England: Nature Publishing Group

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4
A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates
A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates
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A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates

Ding, Huiping ; Kiguchi, Norikazu ; Yasuda, Dennis ; Daga, Pankaj R ; Polgar, Willma E ; Lu, James J ; Czoty, Paul W ; Kishioka, Shiroh ; Zaveri, Nurulain T ; Ko, Mei-Chuan

Science translational medicine, 2018-08, Vol.10 (456) [Periódico revisado por pares]

United States: The American Association for the Advancement of Science

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5
Molecular insights into the biased signaling mechanism of the μ-opioid receptor
Molecular insights into the biased signaling mechanism of the μ-opioid receptor
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Molecular insights into the biased signaling mechanism of the μ-opioid receptor

Cong, Xiaojing ; Maurel, Damien ; Déméné, Hélène ; Vasiliauskaité-Brooks, Ieva ; Hagelberger, Joanna ; Peysson, Fanny ; Saint-Paul, Julie ; Golebiowski, Jérôme ; Granier, Sébastien ; Sounier, Rémy

Molecular cell, 2021-10, Vol.81 (20), p.4165-4175.e6 [Periódico revisado por pares]

United States: Elsevier Inc

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6
Optimization of a Series of Mu Opioid Receptor (MOR) Agonists with High G Protein Signaling Bias
Optimization of a Series of Mu Opioid Receptor (MOR) Agonists with High G Protein Signaling Bias
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Optimization of a Series of Mu Opioid Receptor (MOR) Agonists with High G Protein Signaling Bias

Kennedy, Nicole M ; Schmid, Cullen L ; Ross, Nicolette C ; Lovell, Kimberly M ; Yue, Zhizhou ; Chen, Yen Ting ; Cameron, Michael D ; Bohn, Laura M ; Bannister, Thomas D

Journal of medicinal chemistry, 2018-10, Vol.61 (19), p.8895-8907 [Periódico revisado por pares]

United States: American Chemical Society

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7
Predicted Mode of Binding to and Allosteric Modulation of the μ‑Opioid Receptor by Kratom’s Alkaloids with Reported Antinociception In Vivo
Predicted Mode of Binding to and Allosteric Modulation of the μ‑Opioid Receptor by Kratom’s Alkaloids with Reported Antinociception In Vivo
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Predicted Mode of Binding to and Allosteric Modulation of the μ‑Opioid Receptor by Kratom’s Alkaloids with Reported Antinociception In Vivo

Zhou, Yuchen ; Ramsey, Steven ; Provasi, Davide ; El Daibani, Amal ; Appourchaux, Kevin ; Chakraborty, Soumen ; Kapoor, Abhijeet ; Che, Tao ; Majumdar, Susruta ; Filizola, Marta

Biochemistry (Easton), 2021-05, Vol.60 (18), p.1420-1429 [Periódico revisado por pares]

United States: American Chemical Society

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8
Multitarget μ‑Opioid Receptor AgonistsNeuropeptide FF Receptor Antagonists Induce Potent Antinociception with Reduced Adverse Side Effects
Multitarget μ‑Opioid Receptor AgonistsNeuropeptide FF Receptor Antagonists Induce Potent Antinociception with Reduced Adverse Side Effects
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Multitarget μ‑Opioid Receptor AgonistsNeuropeptide FF Receptor Antagonists Induce Potent Antinociception with Reduced Adverse Side Effects

De Neve, Jolien ; Elhabazi, Khadija ; Gonzalez, Simon ; Herby, Claire ; Schneider, Séverine ; Utard, Valérie ; Fellmann-Clauss, Rosine ; Petit-Demouliere, Nathalie ; Lecat, Sandra ; Kremer, Mélanie ; Ces, Aurelia ; Daubeuf, François ; Martin, Charlotte ; Ballet, Steven ; Bihel, Frédéric ; Simonin, Frédéric

Journal of medicinal chemistry, 2024-05, Vol.67 (9), p.7603-7619 [Periódico revisado por pares]

United States: American Chemical Society

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9
Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications
Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications
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Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications

Vardanyan, Ruben S ; Hruby, Victor J

Future medicinal chemistry, 2014-03, Vol.6 (4), p.385-412 [Periódico revisado por pares]

England

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10
Assessment of structure-activity relationships and biased agonism at the Mu opioid receptor of novel synthetic opioids using a novel, stable bio-assay platform
Assessment of structure-activity relationships and biased agonism at the Mu opioid receptor of novel synthetic opioids using a novel, stable bio-assay platform
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Assessment of structure-activity relationships and biased agonism at the Mu opioid receptor of novel synthetic opioids using a novel, stable bio-assay platform

Vasudevan, Lakshmi ; Vandeputte, Marthe ; Deventer, Marie ; Wouters, Elise ; Cannaert, Annelies ; Stove, Christophe P.

Biochemical pharmacology, 2020-07, Vol.177, p.113910, Article 113910 [Periódico revisado por pares]

England: Elsevier Inc

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