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Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma
Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma
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Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma

Jin, Nan ; Keam, Bhumsuk ; Cho, Janice ; Lee, Michelle J ; Kim, Hye Ryun ; Torosyan, Hayarpi ; Jura, Natalia ; Ng, Patrick Ks ; Mills, Gordon B ; Li, Hua ; Zeng, Yan ; Barbash, Zohar ; Tarcic, Gabi ; Kang, Hyunseok ; Bauman, Julie E ; Kim, Mi-Ok ; VanLandingham, Nathan K ; Swaney, Danielle L ; Krogan, Nevan J ; Johnson, Daniel E ; Grandis, Jennifer R

The Journal of clinical investigation, 2021-11, Vol.131 (22), p.1-15 [Periódico revisado por pares]

United States: American Society for Clinical Investigation

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2
Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue
Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue
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Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue

Araiz, Caroline ; Yan, Anqi ; Bettedi, Lucia ; Samuelson, Isabella ; Virtue, Sam ; McGavigan, Anne K ; Dani, Christian ; Vidal-Puig, Antonio ; Foukas, Lazaros C

Nature communications, 2019-04, Vol.10 (1), p.1546-14, Article 1546 [Periódico revisado por pares]

England: Nature Publishing Group

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3
Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors
Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors
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Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors

Vasan, Neil ; Razavi, Pedram ; Johnson, Jared L ; Shao, Hong ; Shah, Hardik ; Antoine, Alesia ; Ladewig, Erik ; Gorelick, Alexander ; Lin, Ting-Yu ; Toska, Eneda ; Xu, Guotai ; Kazmi, Abiha ; Chang, Matthew T ; Taylor, Barry S ; Dickler, Maura N ; Jhaveri, Komal ; Chandarlapaty, Sarat ; Rabadan, Raul ; Reznik, Ed ; Smith, Melissa L ; Sebra, Robert ; Schimmoller, Frauke ; Wilson, Timothy R ; Friedman, Lori S ; Cantley, Lewis C ; Scaltriti, Maurizio ; Baselga, José

Science (American Association for the Advancement of Science), 2019-11, Vol.366 (6466), p.714-723 [Periódico revisado por pares]

United States: The American Association for the Advancement of Science

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4
PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis
PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis
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PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis

Yu, Kwanha ; Lin, Chia-Ching John ; Hatcher, Asante ; Lozzi, Brittney ; Kong, Kathleen ; Huang-Hobbs, Emmet ; Cheng, Yi-Ting ; Beechar, Vivek B ; Zhu, Wenyi ; Zhang, Yiqun ; Chen, Fengju ; Mills, Gordon B ; Mohila, Carrie A ; Creighton, Chad J ; Noebels, Jeffrey L ; Scott, Kenneth L ; Deneen, Benjamin

Nature (London), 2020-02, Vol.578 (7793), p.166-171 [Periódico revisado por pares]

England: Nature Publishing Group

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5
Targeting the PI3-kinase pathway in triple-negative breast cancer
Targeting the PI3-kinase pathway in triple-negative breast cancer
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Targeting the PI3-kinase pathway in triple-negative breast cancer

Pascual, J. ; Turner, N.C.

Annals of oncology, 2019-07, Vol.30 (7), p.1051-1060 [Periódico revisado por pares]

England: Elsevier Ltd

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6
Herpesviruses in the Activated Phosphatidylinositol-3-Kinase-δ Syndrome
Herpesviruses in the Activated Phosphatidylinositol-3-Kinase-δ Syndrome
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Herpesviruses in the Activated Phosphatidylinositol-3-Kinase-δ Syndrome

Cohen, Jeffrey I

Frontiers in immunology, 2018-02, Vol.9, p.237-237 [Periódico revisado por pares]

Switzerland: Frontiers Media S.A

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7
PIK3CA in cancer: The past 30 years
PIK3CA in cancer: The past 30 years
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PIK3CA in cancer: The past 30 years

Arafeh, Rand ; Samuels, Yardena

Seminars in cancer biology, 2019-12, Vol.59, p.36-49 [Periódico revisado por pares]

England: Elsevier Ltd

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8
Inhibition of Human Class I vs Class III Phosphatidylinositol 3′-Kinases
Inhibition of Human Class I vs Class III Phosphatidylinositol 3′-Kinases
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Inhibition of Human Class I vs Class III Phosphatidylinositol 3′-Kinases

Hassett, Matthew R ; Sternberg, Anna R ; Roepe, Paul D

Biochemistry (Easton), 2017-08, Vol.56 (33), p.4326-4334 [Periódico revisado por pares]

United States: American Chemical Society

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9
Biomarkers of response and resistance to PI3K inhibitors in estrogen receptor-positive breast cancer patients and combination therapies involving PI3K inhibitors
Biomarkers of response and resistance to PI3K inhibitors in estrogen receptor-positive breast cancer patients and combination therapies involving PI3K inhibitors
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Biomarkers of response and resistance to PI3K inhibitors in estrogen receptor-positive breast cancer patients and combination therapies involving PI3K inhibitors

Brandão, M ; Caparica, R ; Eiger, D ; de Azambuja, E

Annals of oncology, 2019-12, Vol.30 (Suppl_10), p.x27-x42 [Periódico revisado por pares]

England: Oxford University Press

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10
Structural Features that Distinguish Inactive and Active PI3K Lipid Kinases
Structural Features that Distinguish Inactive and Active PI3K Lipid Kinases
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Structural Features that Distinguish Inactive and Active PI3K Lipid Kinases

Zhang, Mingzhen ; Jang, Hyunbum ; Nussinov, Ruth

Journal of molecular biology, 2020-11, Vol.432 (22), p.5849-5859 [Periódico revisado por pares]

England: Elsevier Ltd

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