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1
Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides
Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides
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Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides

Becker, Sidney ; Feldmann, Jonas ; Wiedemann, Stefan ; Okamura, Hidenori ; Schneider, Christina ; Iwan, Katharina ; Crisp, Antony ; Rossa, Martin ; Amatov, Tynchtyk ; Carell, Thomas

Science (American Association for the Advancement of Science), 2019-10, Vol.366 (6461), p.76-82 [Revista revisada por pares]

United States: The American Association for the Advancement of Science

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2
In silico design of novel probes for the atypical opioid receptor MRGPRX2
In silico design of novel probes for the atypical opioid receptor MRGPRX2
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In silico design of novel probes for the atypical opioid receptor MRGPRX2

Lansu, Katherine ; Karpiak, Joel ; Liu, Jing ; Huang, Xi-Ping ; McCorvy, John D ; Kroeze, Wesley K ; Che, Tao ; Nagase, Hiroshi ; Carroll, Frank I ; Jin, Jian ; Shoichet, Brian K ; Roth, Bryan L

Nature chemical biology, 2017-05, Vol.13 (5), p.529-536 [Revista revisada por pares]

United States: Nature Publishing Group

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3
Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors
Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors
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Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

Zhang, Tinghu ; Kwiatkowski, Nicholas ; Olson, Calla M ; Dixon-Clarke, Sarah E ; Abraham, Brian J ; Greifenberg, Ann K ; Ficarro, Scott B ; Elkins, Jonathan M ; Liang, Yanke ; Hannett, Nancy M ; Manz, Theresa ; Hao, Mingfeng ; Bartkowiak, Bartlomiej ; Greenleaf, Arno L ; Marto, Jarrod A ; Geyer, Matthias ; Bullock, Alex N ; Young, Richard A ; Gray, Nathanael S

Nature chemical biology, 2016-10, Vol.12 (10), p.876-884 [Revista revisada por pares]

United States: Nature Publishing Group

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4
Molecular basis of USP7 inhibition by selective small-molecule inhibitors
Molecular basis of USP7 inhibition by selective small-molecule inhibitors
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Molecular basis of USP7 inhibition by selective small-molecule inhibitors

Turnbull, Andrew P ; Ioannidis, Stephanos ; Krajewski, Wojciech W ; Pinto-Fernandez, Adan ; Heride, Claire ; Martin, Agnes C L ; Tonkin, Louise M ; Townsend, Elizabeth C ; Buker, Shane M ; Lancia, David R ; Caravella, Justin A ; Toms, Angela V ; Charlton, Thomas M ; Lahdenranta, Johanna ; Wilker, Erik ; Follows, Bruce C ; Evans, Nicola J ; Stead, Lucy ; Alli, Cristina ; Zarayskiy, Vladislav V ; Talbot, Adam C ; Buckmelter, Alexandre J ; Wang, Minghua ; McKinnon, Crystal L ; Saab, Fabienne ; McGouran, Joanna F ; Century, Hannah ; Gersch, Malte ; Pittman, Marc S ; Marshall, C Gary ; Raynham, Tony M ; Simcox, Mary ; Stewart, Lorna M D ; McLoughlin, Sheila B ; Escobedo, Jaime A ; Bair, Kenneth W ; Dinsmore, Christopher J ; Hammonds, Tim R ; Kim, Sunkyu ; Urbé, Sylvie ; Clague, Michael J ; Kessler, Benedikt M ; Komander, David

Nature (London), 2017-10, Vol.550 (7677), p.481-486 [Revista revisada por pares]

England: Nature Publishing Group

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5
Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions
Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions
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Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions

Sutherland, John D ; Powner, Matthew W ; Gerland, Béatrice

Nature, 2009-05, Vol.459 (7244), p.239-242 [Revista revisada por pares]

London: Nature Publishing Group

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6
Kinetically E-selective macrocyclic ring-closing metathesis
Kinetically E-selective macrocyclic ring-closing metathesis
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Kinetically E-selective macrocyclic ring-closing metathesis

Shen, Xiao ; Nguyen, Thach T ; Koh, Ming Joo ; Xu, Dongmin ; Speed, Alexander W H ; Schrock, Richard R ; Hoveyda, Amir H

Nature (London), 2017-01, Vol.541 (7637), p.380-385 [Revista revisada por pares]

England: Nature Publishing Group

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7
Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages
Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages
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Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages

Clark, Kristopher ; MacKenzie, Kirsty F ; Petkevicius, Kasparas ; Kristariyanto, Yosua ; Zhang, Jiazhen ; Choi, Hwan Geun ; Peggie, Mark ; Plater, Lorna ; Pedrioli, Patrick G. A ; McIver, Ed ; Gray, Nathanael S ; Arthur, J. Simon C ; Cohen, Philip

Proceedings of the National Academy of Sciences - PNAS, 2012-10, Vol.109 (42), p.16986-16991 [Revista revisada por pares]

United States: National Academy of Sciences

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8
A flow-based synthesis of imatinib: the API of Gleevec
A flow-based synthesis of imatinib: the API of Gleevec
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A flow-based synthesis of imatinib: the API of Gleevec

Hopkin, Mark D ; Baxendale, Ian R ; Ley, Steven V

Chemical communications (Cambridge, England), 2010-01, Vol.46 (14), p.2450-2452 [Revista revisada por pares]

England

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9
Helical mesoporous silica as an inorganic heterogeneous chiral trigger for asymmetric autocatalysis with amplification of enantiomeric excess
Helical mesoporous silica as an inorganic heterogeneous chiral trigger for asymmetric autocatalysis with amplification of enantiomeric excess
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Helical mesoporous silica as an inorganic heterogeneous chiral trigger for asymmetric autocatalysis with amplification of enantiomeric excess

Kawasaki, Tsuneomi ; Araki, Yuko ; Hatase, Kunihiko ; Suzuki, Kenta ; Matsumoto, Arimasa ; Yokoi, Toshiyuki ; Kubota, Yoshihiro ; Tatsumi, Takashi ; Soai, Kenso

Chemical communications (Cambridge, England), 2015-05, Vol.51 (42), p.8742-8744 [Revista revisada por pares]

England

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10
Characterization of EHop-016, Novel Small Molecule Inhibitor of Rac GTPase
Characterization of EHop-016, Novel Small Molecule Inhibitor of Rac GTPase
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Characterization of EHop-016, Novel Small Molecule Inhibitor of Rac GTPase

Montalvo-Ortiz, Brenda L. ; Castillo-Pichardo, Linette ; Hernández, Eliud ; Humphries-Bickley, Tessa ; De La Mota-Peynado, Alina ; Cubano, Luis A. ; Vlaar, Cornelis P. ; Dharmawardhane, Suranganie

The Journal of biological chemistry, 2012-04, Vol.287 (16), p.13228-13238 [Revista revisada por pares]

United States: Elsevier Inc

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